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GLS1 Inhibitor

GLS1 Inhibitor Structure
GLS1 Inhibitor structure
CAS No.
1832646-52-2
Chemical Name:
GLS1 Inhibitor
Synonyms
GLS1 Inhibitor,GLS-1 Inhibitor;4-thiadiazol-2-yl]-benzeneacetamide;αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1;ΑS-METHOXY-N-[5-[[(3R)-1-(3-PYRIDAZINYL)-3-PYRROLIDINYL]AMINO]-1;3;4-THIADIAZOL-2-YL]-BENZENEACETAMIDE;Benzeneacetamide, α-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-, (αS)-;(2S)-2-methoxy-2-phenyl-N-(5-{[(3R)-1-(pyridazin-3-yl)pyrrolidin-3-yl]amino}-1,3,4-thiadiazol-2-yl)acetamide - [AC78023]
CBNumber:
CB75582380
Molecular Formula:
C19H21N7O2S
Molecular Weight:
411.48
MDL Number:
MOL File:
1832646-52-2.mol
MSDS File:
SDS
Last updated:2026-07-16 07:06:08
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GLS1 Inhibitor Properties

Density 1.425±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form A crystalline solid
pka 7.42±0.50(Predicted)
color White to light yellow

GLS1 Inhibitor price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28581 GLS1 Inhibitor ≥98% 1832646-52-2 1mg $36 2026-04-30 Buy
Cayman Chemical 28581 GLS1 Inhibitor ≥98% 1832646-52-2 5mg $103 2026-04-30 Buy
Cayman Chemical 28581 GLS1 Inhibitor ≥98% 1832646-52-2 10mg $153 2026-04-30 Buy
ChemScene CS-0133394 GLS1 Inhibitor-1 98.5% 1832646-52-2 5mg $233 2026-06-04 Buy
ChemScene CS-0133394 GLS1 Inhibitor-1 98.5% 1832646-52-2 10mg $379 2026-06-04 Buy
Product number Packaging Price Buy
28581 1mg $36 Buy
28581 5mg $103 Buy
28581 10mg $153 Buy
CS-0133394 5mg $233 Buy
CS-0133394 10mg $379 Buy

GLS1 Inhibitor Chemical Properties, Uses, Production

Description

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM). It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.

Uses

GLS1 Inhibitor-1 (Compound 27) is an orally active inhibitor for glutaminase 1 (GLS1) with an IC50 of 0.021 μM. GLS1 Inhibitor-1 inhibits the proliferation of PC-3 with an IC50 of 0.3 nM. GLS1 Inhibitor-1 exhibits antitumor efficacy against NCI-H1703 with GI50 of 0.011 μM. GLS1 Inhibitor-1 exhibits moderate pharmacokinetic characteristics[1].

References

[1] Finlay MRV, et al., Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem. 2019 Jul 25;62(14):6540-6560. DOI:10.1021/acs.jmedchem.9b00260

GLS1 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

GLS1 Inhibitor Suppliers

Global Suppliers ( 10)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Latest Price from GLS1 Inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GLS1 Inhibitor pictures 2026-07-15 GLS1 Inhibitor
1832646-52-2
 $113.00-493.00 10g TargetMol Chemicals Inc.

1832646-52-2 (GLS1 Inhibitor) Related Search:

GLS1 Inhibitor Glutaminase C-IN-2 5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide PKM2 inhibitor GLS1 (human, recombinant)
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4-thiadiazol-2-yl]-benzeneacetamide αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1 ΑS-METHOXY-N-[5-[[(3R)-1-(3-PYRIDAZINYL)-3-PYRROLIDINYL]AMINO]-1;3;4-THIADIAZOL-2-YL]-BENZENEACETAMIDE Benzeneacetamide, α-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-, (αS)- GLS1 Inhibitor,GLS-1 Inhibitor (2S)-2-methoxy-2-phenyl-N-(5-{[(3R)-1-(pyridazin-3-yl)pyrrolidin-3-yl]amino}-1,3,4-thiadiazol-2-yl)acetamide - [AC78023] 1832646-52-2