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4-(2-Methoxyphenyl)piperidine

4-(2-Methoxyphenyl)piperidine Structure
4-(2-Methoxyphenyl)piperidine structure
CAS No.
58333-75-8
Chemical Name:
4-(2-Methoxyphenyl)piperidine
Synonyms
4-(2-Methoxyphenyl);2-(Piperidin-4-yl)anisole;4-(2-Methoxyphenyl)piperidine;Piperidine,4-(2-methoxyphenyl)-
CBNumber:
CB7669983
Molecular Formula:
C12H17NO
Molecular Weight:
191.27
MDL Number:
MFCD00277219
MOL File:
58333-75-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:05
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4-(2-Methoxyphenyl)piperidine Properties

Melting point 54 °C
Boiling point 115-118 °C(Press: 1.1 Torr)
Density 1.003±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 10.22±0.10(Predicted)
Appearance Off-white to light brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38-52/53
Safety Statements  26-36/37/39-61
Hazard Note  Irritant
HS Code  2933399990
NFPA 704
1
2 0

4-(2-Methoxyphenyl)piperidine price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR0044 4-(2-Methoxyphenyl)piperidine 97% 58333-75-8 250mg $41 2026-06-04 Buy
Activate Scientific AS47669-A 4-(2-Methoxyphenyl)piperidine 95% 58333-75-8 1g $67 2026-06-04 Buy
Apolloscientific OR0044 4-(2-Methoxyphenyl)piperidine 97% 58333-75-8 1g $82 2026-06-04 Buy
Activate Scientific AS47669-A 4-(2-Methoxyphenyl)piperidine 95% 58333-75-8 5g $297 2026-06-04 Buy
Apolloscientific OR0044 4-(2-Methoxyphenyl)piperidine 97% 58333-75-8 5g $286 2026-06-04 Buy
Product number Packaging Price Buy
OR0044 250mg $41 Buy
AS47669-A 1g $67 Buy
OR0044 1g $82 Buy
AS47669-A 5g $297 Buy
OR0044 5g $286 Buy

4-(2-Methoxyphenyl)piperidine Chemical Properties,Uses,Production

Synthesis

1,1-Dimethylethyl 4-(2-methoxyphenyl)-1-piperidinecarboxylate

201609-29-2

4-(2-METHOXYPHENYL)PIPERIDINE

58333-75-8

General procedure for the synthesis of 4-(2-methoxyphenyl)piperidine-1-carboxylic acid tert-butyl ester from 4-(2-methoxyphenyl)piperidine-1-carboxylic acid: a solution of 4-(2-methoxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (70 mg, 0.24 mmol) with 10% wet Pd/C (10 mg) in 10 mL of ethyl acetate was purged three times with N2 and then stirred in H2 atmosphere (50 psi) with stirring overnight. After completion of the reaction, the suspension was filtered and the filtrate was evaporated in vacuum to give 4-(2-methoxyphenyl)piperidine (70 mg, yield: 99%) as a colorless oil. 4-(2-methoxyphenyl)piperidine (70 mg, 0.24 mmol) was dissolved in 5 mL HCl/dioxane and stirred overnight at room temperature. After completion of the reaction, the solution was evaporated to dryness in vacuum. The solid was washed with ether to give 4-(2-methoxyphenyl)piperidine hydrochloride (35 mg, yield: 76%) as a white solid.

References

[1] Patent: WO2014/100501, 2014, A1. Location in patent: Paragraph 00407
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 14, p. 1851 - 1856
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8685 - 8699,15
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8685 - 8699

4-(2-Methoxyphenyl)piperidine Preparation Products And Raw materials

Raw materials

1,1-Dimethylethyl 4-(2-methoxyphenyl)-1-piperidinecarboxylate 1,4-Dioxane Hydrochloric acid

Preparation Products

4-(2-Methoxyphenyl)piperidine Suppliers

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Shanghai Cuisen Pharmaceutical Technology Co., Ltd. 13472757003 yongnan.wang@cendrix.cn China 971 65
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2283 55
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Shanghai Cuisen Pharmaceutical Technology Co., Ltd. 65
Syntechem Co.,Ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Thermo Fisher Scientific 75

View Lastest Price from 4-(2-Methoxyphenyl)piperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(2-METHOXYPHENYL)PIPERIDINE pictures 2020-01-13 4-(2-METHOXYPHENYL)PIPERIDINE
58333-75-8
 $5.00 1KG 98% 100KG Career Henan Chemical Co

4-(2-Methoxyphenyl)piperidine Spectrum

4-(2-METHOXYPHENYL)PIPERIDINE(58333-75-8)1HNMR

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2-(Piperidin-4-yl)anisole Piperidine,4-(2-methoxyphenyl)- 4-(2-Methoxyphenyl) 4-(2-Methoxyphenyl)piperidine 58333-75-8 58333-75-9