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H-D-Cha-OH

H-D-Cha-OH Structure
H-D-Cha-OH structure
CAS No.
58717-02-5
Chemical Name:
H-D-Cha-OH
Synonyms
D-CYCLOHEXYLALANINE;3-CYCLOHEXYL-D-ALANINE;(R)-2-AMINO-3-CYCLOHEXYLPROPANOIC ACID;H-D-Cha-OH;(R)-2-Amino-3-cycL;3-3-CYCLOHEXLALANINE;H-D-CHA-OH USP/EP/BP;H-D-PHE(HEXAHYDRO)-OH;D-3-Cyclohexylalanine;β-Cyclohexyl-D-alanine
CBNumber:
CB7701438
Molecular Formula:
C9H17NO2
Molecular Weight:
171.24
MDL Number:
MFCD00153485
MOL File:
58717-02-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:05
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H-D-Cha-OH Properties

Melting point 218-220 °C
Boiling point 307.1±25.0 °C(Predicted)
Density 1.075
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
pka 2.33±0.10(Predicted)
form Solid
color White to Off-White
optical activity [α]20/D 12±1°, c = 1% in 1 M HCl (dry matter)
BRN 3197315
Major Application peptide synthesis
InChI InChI=1/C9H17NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h7-8H,1-6,10H2,(H,11,12)/t8-/s3
InChIKey ORQXBVXKBGUSBA-MRVPVSSYSA-N
SMILES C1(CCCCC1)C[C@@H](N)C(=O)O |&1:7,r|
CAS DataBase Reference 58717-02-5(CAS DataBase Reference)
FDA UNII CX76B5H6YN
UNSPSC Code 12352200
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25
WGK Germany  3
HS Code  29224999
Storage Class 13 - Non Combustible Solids

H-D-Cha-OH price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 270358 beta-Cyclohexyl-D-alanine Asreported 58717-02-5 1g $333 2026-06-03 Buy
TRC TRC-C986070-5G (R)-D-Cyclohexylalanine 58717-02-5 5g $123 2026-06-03 Buy
TRC TRC-C986070-1G (R)-D-Cyclohexylalanine 58717-02-5 1g $98 2026-06-03 Buy
TRC TRC-C986070-10G (R)-D-Cyclohexylalanine 58717-02-5 10g $161 2026-06-03 Buy
AstaTech 59466 D-3-CYCLOHEXYLALANINE 97% 58717-02-5 25G $47 2026-04-30 Buy
Product number Packaging Price Buy
270358 1g $333 Buy
TRC-C986070-5G 5g $123 Buy
TRC-C986070-1G 1g $98 Buy
TRC-C986070-10G 10g $161 Buy
59466 25G $47 Buy

H-D-Cha-OH Chemical Properties, Uses, Production

Chemical Properties

White to off-white crystalline powder

Uses

(R)-2-amino-3-cyclohexylpropanoic acid is an alanine derivative[1].

Application

H-D-CHA-OH is thrombin inhibitor.

Synthesis

Cyclohexanepropionic acid

701-97-3

L-Cyclohexylalanine

27527-05-5

H-D-CHA-OH

58717-02-5

General procedure for the synthesis of (S)-2-Amino-3-cyclohexylpropionic acid and (R)-2-Amino-3-cyclohexylpropionic acid from 3-cyclohexylpropionic acid: pyridoxamine 4a (2.1 mg, 0.0050 mmol), 4-(naphthalen-1-yl)-2-oxo-butyric acid (1a) (22.8 mg, 0.10 mmol), 2,2-diphenylglycine 11 ( 22.7 mg, 0.10 mmol), CH3COOH (48.0 mg, 0.80 mmol), EtOH (0.40 mL), and H2O (0.10 mL) were stirred for 24 hours at 25 °C. Upon completion of the reaction, the mixture was transferred to a 25 mL aubergine flask and methanol (10 mL) was added to completely dissolve the solid, followed by silica gel (0.50 g). The solvent was removed under reduced pressure at 25 °C. The residue was purified by fast column chromatography (silica gel, eluent ratio EtOH/ethyl acetate/25-28% aqueous ammonia solution = 100:58:16) to afford amino acid 2a (22.0 mg, 96% yield, 83% ee) as a white solid. To determine the enantiomeric excess (ee) of 2a, the amino acid was first converted to the corresponding methyl ester by treatment with diazomethane in methanol at room temperature, and subsequently analyzed by HPLC (Chiralcel OD-H column, mobile phase n-hexane: isopropanol = 85:15, flow rate 1.0 mL/min). The enantiomeric excesses (ee) of the products 2b-1 and 2o, as well as the dr values of the products 2m-n, were determined by converting the amino acids to the corresponding N-benzoyl methyl esters by treatment with thionyl chloride in methanol, then reacting with benzoic anhydride, and finally analyzed by HPLC.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1036. DOI:10.1080/10408398.2012.708368

H-D-Cha-OH Preparation Products And Raw materials

Raw materials

3-cyclohexyl-2-oxopropanoic acid Cyclohexanepropionic acid 2,2-Diphenylglycine Water Ethanol
Acetic acid

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Preparation Products

H-D-Cha-OH Suppliers

Global Suppliers ( 166)
Supplier Tel Email Country ProdList Advantage
Taizhou Tianhong Biochemistry Technology Co., Ltd. 0523-86132544 15366717810 sales@thbiochem.com China 407 55
YangZhou Ruihong Biotech Co., Ltd. 0514-015380367604 15380367604 sales@ruibobiotech.com China 509 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Suzhou haiyu Biochem Industrial Co., LTD 512-68097639 18013585858 744942877@qq.com China 915 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Supplier Advantage
Taizhou Tianhong Biochemistry Technology Co., Ltd. 55
YangZhou Ruihong Biotech Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64
Suzhou haiyu Biochem Industrial Co., LTD 62
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60

View Latest Price from H-D-Cha-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H-D-CHA-OH pictures 2019-12-23 H-D-CHA-OH
58717-02-5
 $1.00 1g 99% 1000KSG Career Henan Chemical Co
  • H-D-CHA-OH pictures
  • H-D-CHA-OH
    58717-02-5
  • $1.00
  • 99%
  • Career Henan Chemical Co

H-D-Cha-OH Spectrum

H-D-CHA-OH(58717-02-5)1HNMR

58717-02-5 (H-D-Cha-OH) Related Search:

Beta-Cyclohexyl-L-Alanine Benzyl Ester-Para- Toluenesulfonate Beta-Cyclohexyl-L-Alanine Benzyl Ester Hydrochloride H-Cha-OH HCl 3-Cyclohexyl-L-alanine amide H-L-Cha-OH*HCl,H-CHA-OH HCL,H-L-CHA-OH,H-CHA-OH
β-Cyclohexyl-L-alanine methyl ester hydrochloride Beta-Cyclohexyl-D-Alanine Benzyl Ester-Para- Toluenesulfonate Beta-Cyclohexyl-D-Alanine Benzyl Ester Hydrochloride H-D-Cha-OH HCl (2S)-2-amino-3-cyclohexylpropanamide:hydrochloride
3-Cyclohexyl-D-alanine methyl ester hydrochloride BOC-D-CHA-OH,BOC-D-CHA-OH H2O,BOC-D-CHA-OH, HYDRATE (R)Octahydro-1H-indole-2-carboxylic acid Fmoc-Cha-OH Fmoc-D-Cha-OH
Boc-Cha-OH dcha Boc-D-Cha-OH dcha Boc-beta-cyclohexyl-Ala-OH

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(R)-2-AMINO-3-CYCLOHEXYL-PROPIONIC ACID (R)-3-CYCLOHEXYLALANINE HEXAHYDRO-D-PHENYLALANINE H-D-PHE(HEXAHYDRO)-OH D-2-AMINO-3-CYCLOHEXYL-PROPIONIC ACID D-2-AMINO-3-HEXAHYDROPHENYL-PROPIONIC ACID BETA-CYCLOHEXYL-D-ALANINE 3-3-CYCLOHEXLALANINE (R)-2-AMINO-3-CYCLOHEXYLPROPANOIC ACID (2R)-2-Amino-3-cyclohexylpropionic acid (R)-3-Cyclohexyl-2-aminopropionic acid (2R)-2-Amino-3-cyclohexylpropanoic acid Cyclohexanepropanoic acid, .alpha.-amino-, (.alpha.R)- D-3-Cyclohexylalanine H-b-Cyclohexyl-D-Ala-OH · HCl β-Cyclohexyl-D-alanine 3-Cyclohexyl-D-alanine hydrate >=99.0% (calc. based on dry substance, NT), ~1 mol/mol water β-Cyclohexyl-D-alanine≥ 99% (Assay) (2R)-2-azaniumyl-3-cyclohexylpropanoate D-2-amino-3-cyclohexylpropanoic acid 3-(R)-3-CYCLOHEXYLALANINE (R)-2-Amino-3-cycL Cyclohexanepropanoic acid, α-amino-, (αR)- (R)-2-Amino-3-cyclohexylpropanoicaci H-D-CHA-OH USP/EP/BP Cyclohexanepropanoicacid, a-amino-, (aR)- 3-Cyclohexyl-D-alanine hydrate D-Cyclohexylalanine 98% 3-CYCLOHEXYL-D-ALANINE D-CYCLOHEXYLALANINE H-D-Cha-OH 58717-02-5 73757-66-5 58777-02-5 Alanine Derivatives Unnatural Amino Acid Derivatives Peptide Synthesis Specialty Synthesis Peptide Alanine Derivatives Peptide Synthesis Unnatural Amino Acid Derivatives