DIPHTHERIA TOXIN
- CAS No.
- 92092-36-9
- Chemical Name:
- DIPHTHERIA TOXIN
- Synonyms
- DIPHTHERIA TOXIN;Diphtheria toxin (CRM197);DIPHTHERIA TOXIN, CRM MUTANT;CORYNEBACTERIUM DIPHTHERIAE TOXIN;(GLU-52)-DIPHTHERIA TOXIN FROM*CORYNEBAC;(glu52)-diphtheria toxin from*corynebacterium dip;Diphtheria Toxin from Corynebacterium diphtheriae;Diphtheria toxin[Glu-52], Corynebacterium diphtheriae;DIPHTHERIA TOXIN, UNNICKED, CORYNEBACTERIUM DIPHTHERIAE;[glu52]-diphtheria toxin from corynebacterium diphtheriae
- CBNumber:
- CB7710959
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00163490
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H330 |
| Precautionary statements | P301+P310+P330-P304+P340+P310 |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 22-24/25-45-36/37-28 |
| RIDADR | 3172 |
| WGK Germany | 3 |
| RTECS | XW5807200 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| Storage Class | 11 - Combustible Solids |
DIPHTHERIA TOXIN price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 322326 | Diphtheria Toxin, Unnicked, Corynebacterium diphtheriae Diphtheria toxin catalyzes ADP-ribosylation of eukaryotic aminoacyltransferase II (EF2) using NAD as | 1 mg | $951 | 2025-07-31 | Buy | |
| Sigma-Aldrich | D0564 | Diphtheria Toxin from Corynebacterium diphtheriae lyophilized powder, Product is in unnicked form | 1 mg | $968 | 2025-07-31 | Buy | |
| Sigma-Aldrich | D0564 | Diphtheria Toxin from Corynebacterium diphtheriae lyophilized powder, Product is in unnicked form | 92092-36-9 | 1MG | $942 | 2024-03-01 | Buy |
| Sigma-Aldrich | 322326 | Diphtheria Toxin, Unnicked, Corynebacterium diphtheriae Diphtheria toxin catalyzes ADP-ribosylation of eukaryotic aminoacyltransferase II (EF2) using NAD as substrate. Activation requires nicking with a protease followed by reduction with DTT. | 1MG | $925 | 2024-03-01 | Buy | |
| Sigma-Aldrich | D2189 | [Glu52]-Diphtheria toxin from Corynebacterium diphtheriae lyophilized powder | 92092-36-9 | 1mg | $879 | 2023-01-07 | Buy |
DIPHTHERIA TOXIN Chemical Properties, Uses, Production
Uses
Diphtheria Toxin, CRM Mutant is an agent that does not have NAD:EF2 ADP-ribosyltransferase activity.
Uses
Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell specific cytotoxicity. The translocation domain of bacterial toxins with natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy.
Biochem/physiol Actions
Inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II.
References
[1] LADOKHIN A S. pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain.[J]. Toxins, 2013, 5 8: 1362-1380. DOI: 10.3390/toxins5081362
[2] MURPHY J R. Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process.[J]. Toxins, 2011, 3 3: 294-308. DOI: 10.3390/toxins3030294
[3] MAREIKE BÜTEPAGE. Intracellular Mono-ADP-Ribosylation in Signaling and Disease.[J]. Cells, 2015, 4 4: 569-595. DOI: 10.3390/cells4040569
DIPHTHERIA TOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
DIPHTHERIA TOXIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| JiangSu Star Science Co.,Ltd | 400-605-7200 15335295587 | 3941881028@qq.com | China | 3755 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Manbo Biomedical Technology Co., Ltd. | 51769110 18221705797 | info@mine-bio.com | China | 405 | 58 |
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