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THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Structure
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE structure
CAS No.
53174-98-4
Chemical Name:
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE
Synonyms
2-Formylthieno[2,3-b]pyridine;THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE;THIENO[2,3-B]PYRIDINE-2-CARBOXALDEHYDE;Thieno[2,3-b]pyridine-2-carboxaldehyde 97%;Thieno[2,3-b]pyridine-2-carboxaldehyde 97+%
CBNumber:
CB7729096
Molecular Formula:
C8H5NOS
Molecular Weight:
163.2
MDL Number:
MFCD07772791
MOL File:
53174-98-4.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51
Product description Number Pack Size Price
Thieno[2,3-b]pyridine-2-carboxaldehyde 97.0% 8H70-1-W2 100mg $52
Thieno[2,3-b]pyridine-2-carboxaldehyde 97.0% 8H70-1-W2 250mg $77
Thieno[2,3-b]pyridine-2-carboxaldehyde 97.0% 8H70-1-W2 1g $232
Thieno[2,3-b]pyridine-2-carbaldehyde Y9351 250mg $253
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE 95.00% CHM0032378 1G $894.76
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THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Properties

Melting point 142 °C
Boiling point 320.2±22.0 °C(Predicted)
Density 1.384±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 3.37±0.40(Predicted)
Appearance Off-white to light brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P280-P271
Hazard Codes  Xi
Risk Statements  36-43
Safety Statements  26-36/37
Hazard Note  Irritant
HS Code  2934999090
NFPA 704
1
2 0

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
SynQuest Laboratories 8H70-1-W2 Thieno[2,3-b]pyridine-2-carboxaldehyde 97.0% 53174-98-4 100mg $52 2021-12-16 Buy
SynQuest Laboratories 8H70-1-W2 Thieno[2,3-b]pyridine-2-carboxaldehyde 97.0% 53174-98-4 250mg $77 2021-12-16 Buy
SynQuest Laboratories 8H70-1-W2 Thieno[2,3-b]pyridine-2-carboxaldehyde 97.0% 53174-98-4 1g $232 2021-12-16 Buy
AK Scientific Y9351 Thieno[2,3-b]pyridine-2-carbaldehyde 53174-98-4 250mg $253 2021-12-16 Buy
American Custom Chemicals Corporation CHM0032378 THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE 95.00% 53174-98-4 1G $894.76 2021-12-16 Buy
Product number Packaging Price Buy
8H70-1-W2 100mg $52 Buy
8H70-1-W2 250mg $77 Buy
8H70-1-W2 1g $232 Buy
Y9351 250mg $253 Buy
CHM0032378 1G $894.76 Buy

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Chemical Properties,Uses,Production

Synthesis

Thieno[2,3-b]pyridine (8CI,9CI)

272-23-1

N,N-Dimethylformamide

68-12-2

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE

53174-98-4

Thieno[2,3-b]pyridine-2-carbaldehyde was synthesized as follows: 1.3 mL (2.08 mmol) of a hexane solution of 0.8 M n-butyllithium was mixed with 0.3 mL (3.3 mmol) of N,N,N',N'-tetramethylethylenediamine under the protection of argon gas and was stirred magnetically for 30 min at room temperature. Subsequently, the reaction mixture was diluted with 5 mL of hexane and cooled in a dry ice-ethanol bath. Under vigorous stirring, 0.23 g (1.7 mmol) of thieno[2,3-b]pyridine was added dropwise (using a small needle syringe). The reaction mixture was stirred in a cooling bath for 7 hours, then slowly warmed to room temperature and continued stirring for 12 hours. After completion of the reaction, the mixture was cooled in an ice bath, 0.15 g (2.1 mmol) of dimethylformamide was added and stirred for 1 hour. Subsequently, 1 mL of ethanol, 3 mL of saturated aqueous ammonium chloride solution and 4 mL of water were added sequentially. The organic layer was separated and the aqueous layer was extracted with chloroform. The organic layers were combined, dried with magnesium sulfate and the solvent was evaporated. The residue was ground with hexane to give 0.18 g (66% yield) of a brown solid with a melting point of 131.5-132.5°C. Recrystallization by ethanol (with the addition of activated charcoal to decolorize the product once) yielded white needle-like crystals. The product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.41 (dd, J = 4.5 Hz, 8.1 Hz, 1H), 7.99 (s, 1H), 8.24 (dd, J = 1.8 Hz, 8.1 Hz, 1H), 8.73 (dd, J = 1.8 Hz, 4.5 Hz, 1H), 10.12 (s, 1H).13C NMR (75 MHz, CDCl3) showed: δ 120.7, 131.8, 132.3, 134.0, 143.2, 150.5, 163.8, 185.0. a carbonyl absorption peak at 1682 cm-1 was observed in the IR spectrum (CHCl3, cm-1). The mass spectrum (EI, 70 eV) showed: m/z [%] = 162 [M]+ (100), 134 [M-CO]+ (26). High-resolution mass spectrum (FAB+) calculated value C8H6NOS [M+1] 164.0170, measured value 164.0167.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 20, p. 1952 - 1956
[2] Tetrahedron Letters, 1994, vol. 35, # 7, p. 1011 - 1014
[3] Journal of Heterocyclic Chemistry, 1974, vol. 11, p. 355 - 361

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

THIENO[2,3-B]PYRIDIN-2-YLMETHANOL Thieno[2,3-b]pyridine (8CI,9CI) N,N-Dimethylformamide N,N,N',N'-Tetramethylethylenediamine n-Butyllithium
Hexane

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Preparation Products

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13456 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 		+86-029-86185165 +8618629664246 guoyuan@eastchinapharm.com China 1615 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39927 58
J & K SCIENTIFIC LTD. 18210857532; 18210857532 jkinfo@jkchemical.com China 96815 76
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17770 75
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22514 55
Bide Pharmatech Ltd. 400-164-7117 13681763483 product02@bidepharm.com China 42446 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 18019252918 sale@amkchem.com China 15197 55
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
J & K SCIENTIFIC LTD. 76
Thermo Fisher Scientific 75
9ding chemical ( Shanghai) Limited 55
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55

View Lastest Price from THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE pictures 2019-07-06 THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE
53174-98-4
 US $1.00 / KG 1KG 95% 500KG Career Henan Chemical Co
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE pictures 2019-07-06 THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE
53174-98-4
 US $1.00 / KG 1KG 95% 500KG Career Henan Chemical Co

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Spectrum

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE(53174-98-4)1HNMR

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THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE THIENO[2,3-B]PYRIDINE-2-CARBOXALDEHYDE Thieno[2,3-b]pyridine-2-carboxaldehyde 97% Thieno[2,3-b]pyridine-2-carboxaldehyde 97+% 2-Formylthieno[2,3-b]pyridine 53174-98-4