Actarit
- CAS No.
- 18699-02-0
- Chemical Name:
- Actarit
- Synonyms
- Orcl;ms932;Mover;FAM79A;TPRG1L;ACTARIT;Ake him;Aktalin;Mirabegron M9;Protein FAM79A
- CBNumber:
- CB7732469
- Molecular Formula:
- C10H11NO3
- Molecular Weight:
- 193.2
- MDL Number:
- MFCD00196165
- MOL File:
- 18699-02-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 173-175°C |
|---|---|
| Boiling point | 449.1±28.0 °C(Predicted) |
| Density | 1.288±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Ethanol, Methanol |
| form | Solid |
| pka | 4.34±0.10(Predicted) |
| color | White to Off-White |
| Merck | 14,133 |
| CAS DataBase Reference | 18699-02-0(CAS DataBase Reference) |
| FDA UNII | HW5B6351RZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| RTECS | CY1542000 |
| HS Code | 29163990 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 1.06, 1.30, 1.95, 2.03 i.p.; 5.68, 5.48, 5.48, 6.12 s.c.; 15.3, 14.7, 14.8, 15.4 orally (Toshida) |
Actarit price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2793 | Actarit >97.0%(GC) | 18699-02-0 | 100mg | $17 | 2026-04-30 | Buy |
| Cayman Chemical | 20852 | Actarit ≥98% | 18699-02-0 | 5g | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 20852 | Actarit ≥98% | 18699-02-0 | 10g | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 20852 | Actarit ≥98% | 18699-02-0 | 25g | $204 | 2026-04-30 | Buy |
| Cayman Chemical | 20852 | Actarit ≥98% | 18699-02-0 | 50g | $333 | 2026-04-30 | Buy |
Actarit Chemical Properties, Uses, Production
Description
Actarit is an orally administered disease-modifying antirheumatic drug launched in Japan. Although its structure resembles that of non-steroidal anti-inflammatory drugs, it has no effect on experimental acute inflammation and has no analgesic or antipyretic effects. Its preventative and therapeutic effects on adjuvant arthritis are mediated via modulation of production and serum level of interleukin-2 which enhances production of suppressor T-cells to the immune system, thereby, preventing development of articular lesions.
Chemical Properties
Crystalline Solid
Originator
Nippon Shlnyaku;Mltaublshl Kasel (Japan)
Uses
Antiarthritic
Uses
Chronic rheumatoid arthritis
Definition
ChEBI: Actarit is an anilide and a member of acetamides.
brand name
Orcl; Mover
Synthesis
1197-55-3
108-24-7
18699-02-0
General procedure: 1.02 mmol of p-aminophenylacetic acid (Wako Pure Pharmaceutical Industries, Ltd.) was dissolved in 50 mL of a solvent mixture of dichloromethane-methanol-water (1:3:1, v/v). Under ice bath cooling conditions, 2.12 mmol of acetic anhydride was slowly added. The reaction mixture was gradually brought to room temperature with stirring and continued to stir overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give 196.4 mg of 2-(4-acetylaminophenyl)acetic acid in 99% yield. The structure of the product was confirmed by 1H-NMR (500 MHz, CD3OD): δ 2.11 (3H, s, Ac), 3.55 (2H, s, Ph-CH2-), 7.21-7.49 (4H, m, aromatic H).
Purification Methods
Crystallise the acid from MeOH/Me2CO, aqueous EtOH or H2O. The amide has m 231o (from 50% aqueous EtOH). [Gabriel Chem Ber 15 841 1882, Cerecedo et al. J Biol Chem 42 238 1924, Tramontano et al. J Am Chem Soc 110 2282 1988, Beilstein 14 II 281.]
References
[1] Patent: EP3363463, 2018, A2. Location in patent: Paragraph 0148
[2] Asian Journal of Chemistry, 2012, vol. 24, # 4, p. 1538 - 1540
[3] Journal of the American Chemical Society, 1988, vol. 110, # 7, p. 2282 - 2286
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 456 - 457
[5] Patent: WO2015/145371, 2015, A1. Location in patent: Page/Page column 40
Actarit Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from Actarit manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | Actarit
18699-02-0
|
$31.00-48.00 | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-08 | Actarit
18699-02-0
|
$31.00-48.00 | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-28 | Actarit
18699-02-0
|
$31.00-48.00 | 99.76% | 10g | TargetMol Chemicals Inc. |
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