Methyl 4-chloro-3-nitrobenzoate
- CAS No.
- 14719-83-6
- Chemical Name:
- Methyl 4-chloro-3-nitrobenzoate
- Synonyms
- Methyl 4-chloro-3-nitrobenzate;4-CHLORO-3-NITROBENZOIC ACID METHYL ESTER;BUTTPARK 97\04-24;RARECHEM AL BF 0170;Methyl 4-chloro-3-ni;Intedanib Impurity 2;OTAVA-BB BB0128620049;Nintedanib impurities7;METHYL 4-CHLORO-3-NITROBENZOATE;METHYL-3-NITRO-4-CHLOROBENZOATE
- CBNumber:
- CB7775770
- Molecular Formula:
- C8H6ClNO4
- Molecular Weight:
- 215.59
- MDL Number:
- MFCD00016989
- MOL File:
- 14719-83-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 80 °C |
|---|---|
| Boiling point | 313.2±22.0 °C(Predicted) |
| Density | 1.5220 |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Light yellow to Green |
| Water Solubility | Soluble in water. |
| BRN | 1643729 |
| InChI | InChI=1S/C8H6ClNO4/c1-14-8(11)5-2-3-6(9)7(4-5)10(12)13/h2-4H,1H3 |
| InChIKey | XRTKWPWDSUNLHS-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 |
| CAS DataBase Reference | 14719-83-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-37 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
Methyl 4-chloro-3-nitrobenzoate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S706744 | METHYL 4-CHLORO-3-NITROBENZOATE AldrichCPR | 14719-83-6 | 50MG | $152 | 2026-04-30 | Buy |
| TCI Chemical | M1779 | Methyl 4-Chloro-3-nitrobenzoate >98.0%(GC) | 14719-83-6 | 5g | $32 | 2026-04-30 | Buy |
| TCI Chemical | M1779 | Methyl 4-Chloro-3-nitrobenzoate >98.0%(GC) | 14719-83-6 | 25g | $95 | 2026-04-30 | Buy |
| Biosynth | FC55023 | 4-Chloro-3-nitrobenzoic acid methyl ester | 14719-83-6 | 0.5kg | $150 | 2026-06-04 | Buy |
| Biosynth | FC55023 | 4-Chloro-3-nitrobenzoic acid methyl ester | 14719-83-6 | 0.25kg | $150 | 2026-06-04 | Buy |
Methyl 4-chloro-3-nitrobenzoate Chemical Properties, Uses, Production
Uses
Methyl 4-chloro-3-nitrobenzoate, is used as starting material for the preparation of the methyl benzoates
Synthesis
67-56-1
96-99-1
14719-83-6
Procedure for the synthesis of methyl 4-chloro-3-nitrobenzoate (1): 4-chloro-3-nitrobenzoic acid (5.0 g, 24.8 mmol) was dissolved in 200 mL of methanol and 4.15 mL (29.8 mmol) of triethylamine was added. The reaction mixture was cooled in an ice-salt bath and 3.19 mL (44.7 mmol) of acetyl chloride was added slowly and dropwise. The reaction mixture was stirred under reflux conditions for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of water and then extracted twice with ethyl acetate (100 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was recrystallized with ether (10 mL) to give white crystals of methyl 4-chloro-3-nitrobenzoate (4.81 g, 92% yield). Thin Layer Chromatography (TLC) Rf = 0.55 (unfolding agent: ethyl acetate/cyclohexane = 7/3); melting point 79-80 °C. Infrared spectroscopy (IR) showed the carbonyl absorption peak located at 1716 cm-1; 1H NMR spectrum (300 MHz, DMSO-d6) δ 3.90 (single peak, 3H, OCH3), 7.90 (double peak, 1H, H5, J5-6 = 8.1 Hz), 8.15 (double-double peak, 1H, H6, J6-5 = 8.1 Hz, J5-2 = 1.5 Hz ), 8.49 (double peaks, 1H, H2, J2-6 = 1.5Hz). Molecular formula: C8H6ClNO4.
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 3927 - 3936
[2] Heterocyclic Communications, 2001, vol. 7, # 5, p. 455 - 460
[3] Chemical Research in Toxicology, 1997, vol. 10, # 4, p. 439 - 449
[4] Synthetic Communications, 2002, vol. 32, # 11, p. 1703 - 1707
[5] Journal of Organic Chemistry, 2003, vol. 68, # 14, p. 5525 - 5533
Methyl 4-chloro-3-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quzhou AMK BioTech Co., Ltd | 0570-3081766 18357083060 | sales@qzamkbio.com | China | 1199 | 55 |
| Shanghai Wanyue Biological Medicine Co., LTD | 17502177640 | 977963479@qq.com | China | 19 | 58 |
| Dalian lichuang Chemical Co., Ltd | 0411-0411-00000000 13644282108 | 3500508746@qq.com | China | 2942 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from Methyl 4-chloro-3-nitrobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | Methyl 4-chloro-3-nitrobenzoate
14719-83-6
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
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- Methyl 4-chloro-3-nitrobenzoate
14719-83-6
- $1.00
- 99%
- Career Henan Chemical Co
