SQUALESTATIN
- CAS No.
- 144541-82-2
- Chemical Name:
- SQUALESTATIN
- Synonyms
- L-694,599;SQUALESTATIN;ZARAGOZIC ACID A SODIUM SALT;Zaragozic acid A trisodium salt
- CBNumber:
- CB7779233
- Molecular Formula:
- C35H47NaO14
- Molecular Weight:
- 714.74
- MDL Number:
- MFCD03788025
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Zaragozic acid A trisodium salt ≥95% (HPLC), microbial | Z2626 | 5mg | $723 |
| Zaragozic acid A trisodium salt | Z150603 | 1mg | $470 |
| ZARAGOZIC ACID A TRISODIUM SALT 95.00% | INB0001014 | 5MG | $1036.09 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
SQUALESTATIN price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Z2626 | Zaragozic acid A trisodium salt ≥95% (HPLC), microbial | 144541-82-2 | 5mg | $723 | 2026-03-19 | Buy |
| TRC | Z150603 | Zaragozic acid A trisodium salt | 144541-82-2 | 1mg | $470 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001014 | ZARAGOZIC ACID A TRISODIUM SALT 95.00% | 144541-82-2 | 5MG | $1036.09 | 2021-12-16 | Buy |
SQUALESTATIN Chemical Properties,Uses,Production
Uses
Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase.
Uses
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
Biochem/physiol Actions
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
SQUALESTATIN Preparation Products And Raw materials
Raw materials
Preparation Products
SQUALESTATIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4769 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44896 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25004 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Santa Cruz Biotechnology Inc | 021-60936350 | scbt@scbt.com | China | 6594 | 58 |
| Beijing Zhongcheng Jinnian Technology Co., Ltd. | 18510511586 | CHINA | 2059 | 58 |
