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ChemicalBook >> CAS DataBase List >>1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine

1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine

1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine Structure
1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine structure
CAS No.
268550-48-7
Chemical Name:
1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine
Synonyms
TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE;CPD0982;8-Boc-2,8-diazaspiro[4.5]decan-1-one;8-Boc-1-oxo-2,8-diazaspiro[4.5]decane;1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate;1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDIN;1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine;2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected;tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carbo;tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate - [B0956]
CBNumber:
CB7792225
Molecular Formula:
C13H22N2O3
Molecular Weight:
254.33
MDL Number:
MFCD08461248
MOL File:
268550-48-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:06
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1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine Properties

Boiling point 424.9±38.0 °C(Predicted)
Density 1.15
storage temp. 2-8°C
pka 16.00±0.20(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C13H22N2O3/c1-12(2,3)18-11(17)15-8-5-13(6-9-15)4-7-14-10(13)16/h4-9H2,1-3H3,(H,14,16)
InChIKey ADPIEGXXCABJCH-UHFFFAOYSA-N
SMILES C1(=O)C2(CCN(C(OC(C)(C)C)=O)CC2)CCN1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P261-P271
HazardClass  IRRITANT
HS Code  2932990090

1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR924090 2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected >95% 268550-48-7 250mg $21 2026-06-04 Buy
Apolloscientific OR924090 2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected >95% 268550-48-7 1g $24 2026-06-04 Buy
Apolloscientific OR924090 2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected >95% 268550-48-7 5g $86 2026-06-04 Buy
Apolloscientific OR924090 2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected >95% 268550-48-7 25g $417 2026-06-04 Buy
Synthonix B0956 tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 99% 268550-48-7 1g $27 2026-05-06 Buy
Product number Packaging Price Buy
OR924090 250mg $21 Buy
OR924090 1g $24 Buy
OR924090 5g $86 Buy
OR924090 25g $417 Buy
B0956 1g $27 Buy

1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine Chemical Properties, Uses, Production

Uses

1-O-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester is a carboxylic acid ester derivative that can be used as a pharmaceutical intermediate in pharmaceutical experimental research and synthesis.

Synthesis

1,4-Piperidinedicarboxylic acid, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester

495414-81-8

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

268550-48-7

B) Synthesis of tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 4-(Cyanomethyl)-1,4-piperidinedicarboxylic acid-1-(1,1-dimethylethyl)4-ethyl ester (2.5 g) was dissolved in methanol (50 mL), and cobalt(II) chloride hexahydrate (1.0 g) and sodium borohydride (1.6 g) were added sequentially under ice bath cooling. The reaction mixture was stirred by keeping the ice bath cool for 2 h. Subsequently, the ice bath was removed and stirring was continued for 2 h at room temperature. The reaction system was then warmed to 60°C for 1 hour. After completion of the reaction, 28% ammonia solution was added to the system and the resulting precipitate was removed by filtration. The filtrate was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: ethyl acetate) to afford the target compound tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate (1.1 g). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 1.25-1.35 (2H, m), 1.40 (9H, s), 1.45-1.58 (2H, m), 1.90-1.98 (2H, m), 2.90 (2H, brs), 3.16 (2H, t, J=7.2Hz), 3.76-3.86 ( 2H, m), 7.56 (1H, brs).

References

[1] Patent: EP2933247, 2015, A1. Location in patent: Paragraph 0334

1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine Preparation Products And Raw materials

Raw materials

1,4-Piperidinedicarboxylic acid, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester Methanol Sodium borohydride Cobalt chloride hexahydrate

Preparation Products

2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1)

1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine Suppliers

Global Suppliers ( 135)
Supplier Tel Email Country ProdList Advantage
Shanghai AQBioPharma Co., Ltd. 13661411401 yinglv.que@aqbiopharma.com.cn China 2976 58
Cangzhou Dimai Technology Co., Ltd 1351-2466848 13512466848 hbdypharm@163.com China 290 58
Shanghai AQ BioPharma Co., Ltd. 13512160998; 13512160998 sales@aqbiopharma.com.cn China 3007 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
NOTA Chemical (Shanghai) Co.,Ltd 021-50189163 sales@notachem.com China 208 64
Santai Labs, Inc. 519-85601385 marketing@santailabs.com China 891 62
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Supplier Advantage
Shanghai AQBioPharma Co., Ltd. 58
Cangzhou Dimai Technology Co., Ltd 58
Shanghai AQ BioPharma Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
Energy Chemical 61
Tetranov Biopharm 64
Accela ChemBio Co.,Ltd. 64
NOTA Chemical (Shanghai) Co.,Ltd 64
Santai Labs, Inc. 62
T&W GROUP 58

View Latest Price from 1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate pictures 2026-08-25 tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
268550-48-7
 $2.00-6.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE pictures 2026-06-30 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
268550-48-7
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE pictures 2025-04-04 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
268550-48-7
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine Spectrum

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE(268550-48-7)1HNMR

268550-48-7 (1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine) Related Search:

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2,8-Diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester tert-Butyl 4-(aminocarbonyl)tetrahydropyridine-1(2H)-carboxylate

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2,8-Diazaspiro[4.5]decane-8-carboxylicacid,1-oxo-,1,1-dimethylethylester 1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester 1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 8-Boc-1-oxo-2,8-diazaspiro[4.5]decane tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carbo 8-Boc-2,8-diazaspiro[4.5]decan-1-one CPD0982 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDIN tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate - [B0956] 2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE 1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine 268550-48-7