Furin Inhibitor II TFA
- CAS No.
- 958204-56-3
- Chemical Name:
- Furin Inhibitor II TFA
- Synonyms
- H-Arg6-NH2;Hexa-D-arginine TFA;Furin Inhibitor II TFA;(S)-2-Amino-N-((6S,9S,12S,15S,18S)-1,23-diamino-6-carbamoyl-9,12,15-tris(3-guanidinopropyl)-1,23-diimino-8,11,14,17-tetraoxo-2,7,10,13,16,22-hexaazatricosan-18-yl)-5-guanidinopentanamide 2,2,2-trifluoroacetate;(R)-2-amino-5-((diaminomethylene)amino)-N-((6R,9R,12R,15R,18R)-1,1,23,23-tetraamino-6-carbamoyl-9,12,15-tris(3-((diaminomethylene)amino)propyl)-8,11,14,17-tetraoxo-2,7,10,13,16,22-hexaazatricosa-1,22-dien-18-yl)pentanamide 2,2,2-trifluoroacetate
- CBNumber:
- CB78054875
- Molecular Formula:
- C36H75N25O6.C2HF3O2
- Molecular Weight:
- 1068.17
- MDL Number:
- MFCD18633383
- MOL File:
- 958204-56-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Furin Inhibitor II TFA price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0113884 | Hexa-D-arginine TFA | 958204-56-3 | 1mg | $76 | 2026-06-04 | Buy |
| ChemScene | CS-0113884 | Hexa-D-arginine TFA | 958204-56-3 | 5mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0113884 | Hexa-D-arginine TFA | 958204-56-3 | 10mg | $347 | 2026-06-04 | Buy |
| ApexBio Technology | B5692 | Hexa-D-arginine TFA | 958204-56-3 | 1mg | $155 | 2026-05-06 | Buy |
| ApexBio Technology | B5692 | Hexa-D-arginine TFA | 958204-56-3 | 5mg | $621 | 2026-05-06 | Buy |
Furin Inhibitor II TFA Chemical Properties,Uses,Production
Uses
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].
in vivo
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].
References
[1] Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. DOI:10.1128/IAI.70.12.7136-7139.2002
[2] Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. DOI:10.1128/IAI.72.1.602-605.2004
[3] Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. DOI:10.1074/jbc.M003848200
Furin Inhibitor II TFA Preparation Products And Raw materials
Raw materials
Preparation Products
Furin Inhibitor II TFA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2447 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7446 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Hangzhou ALLPEPTIDE Biotechnology Co., Ltd. | 17342063383 | sales@allpeptide.com | China | 5319 | 58 |
| Fuan Bio | 15002819872 | 2845971812@qq.com | China | 2103 | 58 |
| SU ZHOU MOTIF BIOTECH CO.,LTD | 18151592215 18516107567 | info@motifbiotech.com | China | 998 | 58 |
| Shanghai Anbida Biotechnology Co., Ltd. | 021-61629020 18201956406 | sales@ambeed.cn | China | 7032 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
