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ChemicalBook >> CAS DataBase List >>5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide

5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide

5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide Structure
5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide structure
CAS No.
874902-19-9
Chemical Name:
5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide
Synonyms
CS-752;LY 2183240;LY2183240 powder;LY-2183240 MN-25;LY2183240/LY-2183240;LY2183240, 10 mM in DMSO;N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide;5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide;5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide;1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-
CBNumber:
CB7842012
Molecular Formula:
C17H17N5O
Molecular Weight:
307.35
MDL Number:
MFCD08703123
MOL File:
874902-19-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:07
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5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide Properties

Melting point 87-88℃
Boiling point 506.1±53.0 °C(Predicted)
Density 1.21
storage temp. Sealed in dry,2-8°C
solubility Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
pka 0.01±0.10(Predicted)
form White to off-white solid.
color White
Stability Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
FDA UNII 2WBU91OKM7

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
NFPA 704
0
2 0

5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10008663 LY2183240 ≥98% 874902-19-9 1mg $103 2026-04-30 Buy
Cayman Chemical 10008663 LY2183240 ≥98% 874902-19-9 5mg $278 2026-04-30 Buy
Usbiological 454032 LY2183240 ≥99%(HPLC) 874902-19-9 5mg $350 2026-06-03 Buy
Usbiological 454032 LY2183240 ≥99%(HPLC) 874902-19-9 25mg $765 2026-06-03 Buy
ChemScene CS-0913 LY2183240 98.00% 874902-19-9 5mg $38 2026-06-04 Buy
Product number Packaging Price Buy
10008663 1mg $103 Buy
10008663 5mg $278 Buy
454032 5mg $350 Buy
454032 25mg $765 Buy
CS-0913 5mg $38 Buy

5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide Chemical Properties, Uses, Production

Description

LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2-4 to be an inhibitor of fatty acid amide hydrolase (FAAH) – IC50 = 14nM4, diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) – IC50 = 5.3 nM3.

Uses

LY2183240 is a potent inhibitor of FAAH activity, and the uptake and enzymatic hydrolysis of anandamide. Synthetic Cannabinoids

Definition

ChEBI: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide is a member of biphenyls.

Biological Activity

Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

in vivo

LY2183240 (3-30mg/kg; i.p.) dose-dependently attenuates formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms[1].

Animal Model:Male Sprague-Dawley rats (Formalin Pain Model)[1]
Dosage:3, 10, 30 mg/kg
Administration:I.p.
Result:Dose-dependently attenuated formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms.

References

[1] S A MOORE. Identification of a high-affinity binding site involved in the transport of endocannabinoids.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 49: 17852-17857. DOI:10.1073/pnas.0507470102
[2] GIORGIO ORTAR . Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitation[J]. European Journal of Medicinal Chemistry, 2008, 43 1: Pages 62-72. DOI:10.1016/j.ejmech.2007.02.023
[3] JESSICA P. ALEXANDER  Benjamin F C. The Putative Endocannabinoid Transport Blocker LY2183240 Is a Potent Inhibitor of FAAH and Several Other Brain Serine Hydrolases[J]. Journal of the American Chemical Society, 2006, 128 30: 9699-9704. DOI:10.1021/ja062999h
[4] AMY K DICKASON-CHESTERFIELD. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors.[J]. Cellular and Molecular Neurobiology, 2006, 26 4-6: 407-423. DOI:10.1007/s10571-006-9072-6

5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide Suppliers

Global Suppliers ( 107)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Hubei XinyuanShun Chemical Co., Ltd. 13971561712, 13995564702, 027-50664929 hbeixys2001@163.com China 3110 55
Credit Asia Chemical Co., Ltd. +86 (21) 61124340 China 9739 58
Chizhou Kailong Import and Export Trade Co., Ltd. xg01_gj@163.com China 9413 50
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
AdooQ BioScience, LLC 58
Hubei XinyuanShun Chemical Co., Ltd. 55
Credit Asia Chemical Co., Ltd. 58
Chizhou Kailong Import and Export Trade Co., Ltd. 50
Shanghai Synchem Pharma Co., ltd 55

View Latest Price from 5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE pictures 2026-09-16 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
874902-19-9
 0.99 RongNa Biotechnology Co.,Ltd
LY2183240 powder pictures 2021-11-15 LY2183240 powder
874902-19-9
 $29.00 1KG 99% 500ton/Month Qiuxian Baitai New Material Co., LTD
N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide pictures 2020-01-10 N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
874902-19-9
 $1.00 1g 99% 200kg Career Henan Chemical Co

5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide Spectrum

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE(874902-19-9)1HNMR

874902-19-9 (5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide) Related Search:

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LY 2183240 LY-2183240 MN-25 1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl- 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide 5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide LY2183240/LY-2183240 CS-752 LY2183240 powder Inhibitor,brain,uptake,transport,hydrolases,Fatty acid amide hydrolase,LY2183240,Autophagy,LY 2183240,serine,anandamide,FAAH,inhibit,LY-2183240 5- ([1,1 '- biphenyl] -4-methyl) - N, N-dimethyl-1H-tetrazol-1-formamide LY2183240, 10 mM in DMSO 5- ([1,1 '- biphenyl] -4-methyl) - N, N-dimethyl-1H-tetrazol-1-formamide 5-[[(1,1'-Biphenyl)-4-yl]methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide 874902-19-9