Thiamethoxam | 153719-23-4

Thiamethoxam Properties

Melting point	139.1°
Boiling point	485.8±55.0 °C(Predicted)
Density	1.71±0.1 g/cm3(Predicted)
vapor pressure	6.6 x 10^-9 Pa (25 °C)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO: 250 mg/mL (857.02 mM)
Water Solubility	4.1 x 10³ mg l^-1 (25 °C)
form	Solid
pka	0.99±0.10(Predicted)
color	Off-white to yellow
BRN	8491021
Henry's Law Constant	2.1×10⁹ mol/(m³Pa) at 25℃, HSDB (2015)
Major Application	agriculture environmental
InChI	InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3
InChIKey	NWWZPOKUUAIXIW-DHZHZOJOSA-N
SMILES	O1CN(C)C(=N[N+]([O-])=O)N(CC2SC(Cl)=NC=2)C1
LogP	-0.13 at 25℃
FDA UNII	747IC8B487
Pesticides Freedom of Information Act (FOIA)	Thiamethoxam
EPA Substance Registry System	Thiamethoxam (153719-23-4)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H302-H410

Precautionary statements

P264-P270-P273-P301+P312-P391-P501

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xn

Risk Statements

22-50/53

Safety Statements

22-61-60

RIDADR

UN 3077 9 / PGIII

WGK Germany

2

HS Code

29341000

Storage Class

4.1B - Flammable solid hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Flam. Sol. 1
Repr. 2

Hazardous Substances Data

153719-23-4(Hazardous Substances Data)

Toxicity

LD50 in rats (mg/kg): 1563 orally, >2000 dermally; LD50 in bobwhite quail, mallard duck (mg/kg): 1552, 576 orally. LC50 (96hr) in rainbow trout, bluegill (mg/l): >100, >114 (Senn).

REACH Registrations

Active

NFPA 704

	0
2		0

Thiamethoxam price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	37924	Thiamethoxam PESTANAL?, analytical standard	153719-23-4	100mg	$98.5	2026-04-30	Buy
TCI Chemical	T3811	Thiamethoxam	153719-23-4	1G	$64	2026-04-30	Buy
TCI Chemical	T3811	Thiamethoxam	153719-23-4	5G	$188	2026-04-30	Buy
TCI Chemical	T3811	Thiamethoxam	153719-23-4	25G	$562	2026-04-30	Buy
Cayman Chemical	25784	Thiamethoxam ≥98%	153719-23-4	50mg	$49	2026-04-30	Buy

Product number	Packaging	Price	Buy
37924	100mg	$98.5	Buy
T3811	1G	$64	Buy
T3811	5G	$188	Buy
T3811	25G	$562	Buy
25784	50mg	$49	Buy

Thiamethoxam Chemical Properties, Uses, Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Thiamethoxam is a broad spectrum insecticide active against a wide spectrum of sucking and chewing insect pests after foliar, soil or seed treatment.

Definition

ChEBI: Thiamethoxam is an oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively. It has a role as an antifeedant, a carcinogenic agent, an environmental contaminant, a xenobiotic and a neonicotinoid insectide. It is an oxadiazane, a member of 1,3-thiazoles, an organochlorine compound and a 2-nitroguanidine derivative. It derives from a 2-chlorothiazole.

Application

Thiamethoxam is a neonicotinoid insecticide that is used widely in Wisconsin. Thiamethoxam is the active ingredient in a variety of products used in agriculture to kill sucking and chewing insects that feed on roots, leaves, and other plant tissues. Agricultural uses include soil and seed treatments as well as leaf spraying for most row and vegetable crops like corn, soybeans, snap beans, and potatoes. It is also used to control insects in livestock pens, poultry houses, sod farms, golf courses, lawns, household plants, and tree nurseries. It was first registered by the U.S. Environmental Protection Agency in 1999. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens.

Flammability and Explosibility

Flammable

Synthesis

105827-91-6

3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine

153719-38-1

153719-23-4

In a 500 ml round bottom flask, 70 g of N,N-dimethylformamide (DMF) as solvent, 150 g of anhydrous potassium carbonate as base, and 80 g of 3-methyl-4-nitroimino-1,3,5-oxadiazine as one of the reactants were added sequentially. The mixture was stirred and warmed to 50°C. 110 g of 2-chloro-5-(chloromethyl)thiazole was added dropwise at a rate of 50 ml/hour in a 250 ml constant pressure dropping funnel, ensuring that the reaction temperature did not exceed 50°C. After the dropwise addition was completed, the reaction was maintained at 50°C for 16 hours. Upon completion of the reaction, the mixture was cooled to 10°C and filtered to obtain the solid product thiamethoxam. Thiamethoxam was analyzed by liquid chromatography with a purity of 98.4% and a yield of 98%.The recovery of N,N-dimethylformamide was 92%.

Metabolic pathway

All the information on thiamethoxam is taken from a summary of the proceedings of meeting published by the manufacturer. Full experimental details are not given in the report and the identity of metabolites is not disclosed (Novartis, 1997).

Degradation

Thiamethoxam is hydrolytically stable at pH 5 (half-life about 200-300 days). The compound is more labile at pH 9 where the half-life is a few days. It is rapidly photodegraded with a half-life of about 1 hour. In aquatic systems, degradation occurs under alkaline conditions and the insecticide is rapidly photodegraded but not readily biodegraded (Novartis, 1997).

Mode of action

Thiamethoxam interferes with nicotinic acetylcholine receptors in the insect’s nervous system, which are essential for proper functioning of the nerves. Within hours of contact or ingestion of thiamethoxam, insects stop feeding. Death usually occurs within 24 to 48 hours.
The activity of thiamethoxam, or any insecticide, at the target site is just one factor in its efficacy. When comparing insecticides, other variables – including how the compound interacts with the environment, the plant and the insect – also contribute to its insecticidal mode of action.
The Insecticide Resistance Action Committee (IRAC) has organized insecticides into 28 groups, plus sub-groups, based on their modes of action. Thiamethoxam is a Group 4A insecticide (neonicotinoids).

References

[1] Patent: CN106188032, 2016, A. Location in patent: Paragraph 0017-0019
[2] Patent: CN103880832, 2016, B. Location in patent: Paragraph 0027-0029
[3] Patent: WO2015/180585, 2015, A1. Location in patent: Page/Page column 13-18
[4] Patent: CN107698578, 2018, A. Location in patent: Paragraph 0028; 0035; 0036; 0040-0042; 0049
[5] Patent: CN108164522, 2018, A. Location in patent: Paragraph 0027; 0030; 0034; 0038

Pesticide Type

Insecticide

Thiamethoxam synthesis

Synthesis of Thiamethoxam from 2-Chloro-5-chloromethylthiazole and 3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine

Thiamethoxam Preparation Products And Raw materials

Raw materials

3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine 2-Chloro-5-chloromethylthiazole N,N-Dimethylformamide Potassium carbonate

Preparation Products

Thiamethoxam Suppliers

Global Suppliers ( 419)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Rudong Zhongyi Chemical Co., Ltd	13306234115	jszyzj@zhongyichem.com	China	36	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
China Langchem Inc.	0086-21-58956006		China	7798	57

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
TAIYUAN RHF CO.,LTD.	56
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Rudong Zhongyi Chemical Co., Ltd	60
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Chemsky（shanghai）International Co.,Ltd.	50
Sichuan Kulinan Technology Co., Ltd	57
China Langchem Inc.	57

View Latest Price from Thiamethoxam manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	Thiamethoxam 153719-23-4	$31.00-77.00		99.86%	10g	TargetMol Chemicals Inc.
2026-07-14	Thiamethoxam 153719-23-4		1kg	95	200000	Qingdao Trust Agri Chemical Co.,Ltd
2026-05-28	Thiamethoxam 153719-23-4	$10.00	1KG	99%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD

Thiamethoxam
153719-23-4
$31.00-77.00
99.86%
TargetMol Chemicals Inc.

Thiamethoxam
153719-23-4
$0.00
95
Qingdao Trust Agri Chemical Co.,Ltd

Thiamethoxam
153719-23-4
$10.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

Thiamethoxam Spectrum

Thiamethoxam(153719-23-4)¹HNMR

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