Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3,5-DIFLUORO-4-HYDROXY-BENZONITRILE

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Structure
3,5-DIFLUORO-4-HYDROXY-BENZONITRILE structure
CAS No.
2967-54-6
Chemical Name:
3,5-DIFLUORO-4-HYDROXY-BENZONITRILE
Synonyms
3,5-DIFLUORO-4-HYDROXY-BENZONITRILE;Benzonitrile, 3,5-difluoro-4-hydroxy-;3,5-Difluoro-4-hydroxybenzonitrile,97%
CBNumber:
CB7843741
Molecular Formula:
C7H3F2NO
Molecular Weight:
155.1
MDL Number:
MFCD09033181
MOL File:
2967-54-6.mol
MSDS File:
SDS
Last updated:2026-05-28 05:10:28
Request For Quotation

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Properties

Melting point 200-208℃
Boiling point 221.0±40.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
pka 5.34±0.23(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Danger
Hazard statements  H302-H312-H315-H319-H332
Precautionary statements  P261-P280-P301+P312a-P304+P340-P305+P351+P338-P501a
HazardClass  6.1
HS Code  2926907090
NFPA 704
1
2 0

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC201222 3,5-Difluoro-4-hydroxybenzonitrile 98% 2967-54-6 100mg $21 2026-06-04 Buy
Apolloscientific PC201222 3,5-Difluoro-4-hydroxybenzonitrile 98% 2967-54-6 250mg $24 2026-06-04 Buy
Apolloscientific PC201222 3,5-Difluoro-4-hydroxybenzonitrile 98% 2967-54-6 1g $40 2026-06-04 Buy
Apolloscientific PC201222 3,5-Difluoro-4-hydroxybenzonitrile 98% 2967-54-6 5g $141 2026-06-04 Buy
Apolloscientific PC201222 3,5-Difluoro-4-hydroxybenzonitrile 98% 2967-54-6 25g $549 2026-06-04 Buy
Product number Packaging Price Buy
PC201222 100mg $21 Buy
PC201222 250mg $24 Buy
PC201222 1g $40 Buy
PC201222 5g $141 Buy
PC201222 25g $549 Buy

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Chemical Properties,Uses,Production

Uses

3,5-Difluoro-4-hydroxybenzonitrile

Synthesis

Benzaldehyde, 3,5-difluoro-4-hydroxy-, oxime, [C(E)]-

960287-97-2

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE

2967-54-6

The general procedure for the synthesis of 3,5-difluoro-4-hydroxybenzonitrile from 3,5-difluoro-4-hydroxybenzaldehyde oxime is as follows: to a solution of tetrahydrofuran (THF, 10 mL) containing the aldoxime (0.01 mol) was added T3P (15 mol%, 50% solution in ethyl acetate (EtOAc)). The reaction mixture was stirred at room temperature for 1-2 h under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with distilled water (20 mL) and subsequently extracted with ethyl acetate (2 x 20 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution (10 mL) and brine. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the target product 3,5-difluoro-4-hydroxybenzonitrile of high purity.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 10, p. 1074 - 1077

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE synthesis

104197-15-1
2967-54-6
Synthesis of 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE from 3,5-DIFLUORO-4-METHOXYBENZONITRILE

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Preparation Products And Raw materials

Raw materials

4-Bromo-2,6-difluorophenol 3,5-DIFLUORO-4-METHOXYBENZONITRILE 3,5-Difluoro-4-hydroxybenzaldehyde Copper(I) Cyanide Benzaldehyde, 3,5-difluoro-4-hydroxy-, oxime, [C(E)]-
Ethyl acetate Propylphosphonic anhydride Tetrahydrofuran

1of2

Preparation Products

3-Fluoro-4-hydroxybenzonitrile

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
SynAsst Chemical. 021-60343070 China 12731 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. 13594048950 19923294409 xingcanyaoye@sina.com China 1591 58
Supplier Advantage
Alfa Aesar 84
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai Topbiochem Technology Co., Ltd 58
SynAsst Chemical. 55
Bide Pharmatech Ltd. 60
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. 58

View Lastest Price from 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,5-DIFLUORO-4-HYDROXY-BENZONITRILE pictures 2019-07-06 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE
2967-54-6
 $1.00 1KG 98% 200kg Career Henan Chemical Co

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Spectrum

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE(2967-54-6)1HNMR

2967-54-6(3,5-DIFLUORO-4-HYDROXY-BENZONITRILE)Related Search:

BISMERTHIAZOL 4-METHOXY-2,3,5-TRIFLUOROBENZONITRILE 3-Fluoro-4-hydroxybenzonitrile 3,5-DIFLUORO-4-METHOXYBENZONITRILE 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE
3,5-Difluoro-4-hydroxybenzaldehyde

1of2

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Benzonitrile, 3,5-difluoro-4-hydroxy- 3,5-Difluoro-4-hydroxybenzonitrile,97% 2967-54-6