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4-Bromo-2,6-difluorophenol

4-Bromo-2,6-difluorophenol structure

CAS No.: 104197-13-9

Chemical Name:: 4-Bromo-2,6-difluorophenol

Synonyms: CAS:104197-13-9;4-Bromo-2,6-difL;4-BROMO-2,6-DIFLUOROPHE;4-BROMO-2,6-DIFLUOROPHENOL;2,6-Difluoro-4-bromophenol;Phenol,4-bromo-2,6-difluoro-;4-Bromo-2,6-difluorophenol98%;4-Bromo-2,6-difluorophenol 98%;4-BROMO-2,6-DIFLUOROPHENOL ISO 9001：2015 REACH;2,6-Difluoro-4-Bromophenol 4-Bromo-2,6-Difluoro Phenol

CBNumber:: CB5378751

Molecular Formula:: C6H3BrF2O

Molecular Weight:: 208.99

MDL Number:: MFCD00236213

MOL File:: 104197-13-9.mol

MSDS File:: SDS

Last updated:2026-08-28 09:47:29

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4-Bromo-2,6-difluorophenol Properties

Melting point	50°C
Boiling point	180.2±35.0 °C(Predicted)
Density	1.858±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	6.89±0.23(Predicted)
Appearance	Off-white to light yellow Solid
BRN	8543473
InChI	InChI=1S/C6H3BrF2O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H
InChIKey	GPRPSJPFAAGLCA-UHFFFAOYSA-N
SMILES	C1(O)=C(F)C=C(Br)C=C1F
CAS DataBase Reference	104197-13-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36/37/39

Hazard Note

Harmful

HazardClass

IRRITANT

HS Code

2908190090

NFPA 704

	1
2		0

4-Bromo-2,6-difluorophenol price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	264008	4-Bromo-2,6-difluorophenol Asreported	104197-13-9	5g	$305	2026-06-03	Buy
Usbiological	264008	4-Bromo-2,6-difluorophenol Asreported	104197-13-9	10g	$418	2026-06-03	Buy
Usbiological	264008	4-Bromo-2,6-difluorophenol Asreported	104197-13-9	25g	$602	2026-06-03	Buy
Usbiological	264008	4-Bromo-2,6-difluorophenol Asreported	104197-13-9	50g	$842	2026-06-03	Buy
Usbiological	264008	4-Bromo-2,6-difluorophenol Asreported	104197-13-9	100g	$1097	2026-06-03	Buy

Product number	Packaging	Price	Buy
264008	5g	$305	Buy
264008	10g	$418	Buy
264008	25g	$602	Buy
264008	50g	$842	Buy
264008	100g	$1097	Buy

4-Bromo-2,6-difluorophenol Chemical Properties,Uses,Production

Chemical Properties

White crystalline

Uses

4-Bromo-2,6-difluorophenol is used as an intermediate in pharmaceuticals and liquid crystal materials.

Synthesis

To a solution of 2,6-Difluorophenol (10.0 g, 76.86 mmol) in DMF (60 mL), N-bromosuccinimide (13.68 g, 76.86 mmol) was added at 0° C. and stirred at RT for 20 h. The reaction mixture was concentrated, diluted with water and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure to afford 4-Bromo-2,6-difluorophenol as a light yellow liquid (15.1 g, 93 percent yield). 1H-NMR (δ ppm, DMSO-D6, 400 MHz): δ 10.49 (s, 1H), 7.35 (d, J=6.2 Hz, 2H).

References

[1] Patent: US2011/118257, 2011, A1. Location in patent: Page/Page column 100
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 3, p. 608 - 617
[3] Patent: WO2014/209034, 2014, A1. Location in patent: Paragraph 410; 411; 412
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3183 - 3203
[5] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0101

4-Bromo-2,6-difluorophenol synthesis

Synthesis of 4-Bromo-2,6-difluorophenol from 2,6-Difluorophenol

4-Bromo-2,6-difluorophenol Preparation Products And Raw materials

Raw materials

1-Bromo-3,5-difluorobenzene 2,6-Difluorophenol N,N-Dimethylformamide N-Bromosuccinimide

Preparation Products

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE 5-BroMo-1,3-Difluoro-2-(PhenylMethoxy)-Benzene

4-Bromo-2,6-difluorophenol Suppliers

Global( 289)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Changzhou Anxuan Chemical, Co., Ltd.	13912302692	sales@anxuanchem.com	China	4824	58
Shanghai Taijilin Industrial Co., Ltd.	02150630626 17717886015	kate@tajilin.com	China	1340	58
Shanghai RC Chemicals Co., Ltd.	21-58661250 18217085189;	3059772675@qq.com	China	131	64
Hebei Boxin Biotechnology Co. , Ltd.	19131160546	2681315246@qq.com	China	13193	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Changzhou Anxuan Chemical, Co., Ltd.	58
Shanghai Taijilin Industrial Co., Ltd.	58
Shanghai RC Chemicals Co., Ltd.	64
Hebei Boxin Biotechnology Co. , Ltd.	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66

View Lastest Price from 4-Bromo-2,6-difluorophenol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	4-BROMO-2,6-DIFLUOROPHENOL 104197-13-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-07-06	4-BROMO-2,6-DIFLUOROPHENOL 104197-13-9	$2.00	1KG	99%		Career Henan Chemical Co

4-BROMO-2,6-DIFLUOROPHENOL
104197-13-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-BROMO-2,6-DIFLUOROPHENOL
104197-13-9
$2.00
99%
Career Henan Chemical Co

104197-13-9(4-Bromo-2,6-difluorophenol)Related Search:

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4-BROMO-2,6-DIFLUOROPHENOL 2,6-Difluoro-4-Bromophenol 4-Bromo-2,6-Difluoro Phenol 2,6-Difluoro-4-bromophenol 4-Bromo-2,6-difluorophenol 98% 4-Bromo-2,6-difluorophenol98% Phenol,4-bromo-2,6-difluoro- 4-Bromo-2,6-difL 4-BROMO-2,6-DIFLUOROPHENOL ISO 9001：2015 REACH 4-BROMO-2,6-DIFLUOROPHE CAS:104197-13-9 104197-13-9 104097-13-9 Aromatic Phenols Phenol&Thiophenol&Mercaptan