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(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester

(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester Structure
(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester structure
CAS No.
257892-43-6
Chemical Name:
(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester
Synonyms
3-(Boc-amino)-1-phenyl-1-propanol;N-Boc-3-hydroxy-3-phenyl-1-propylamine;Tert-Butyl (3-hydroxy-3-phenylpropyl)carbaMate;(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester;Carbamic acid, N-(3-hydroxy-3-phenylpropyl)-, 1,1-dimethylethyl ester
CBNumber:
CB7844016
Molecular Formula:
C14H21NO3
Molecular Weight:
251.32
MDL Number:
MFCD09026397
MOL File:
Mol file
Last updated:2026-09-12 18:55:07
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(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester Properties

Boiling point 404.6±38.0 °C(Predicted)
Density 1.083±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 12.70±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS38657 tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate 97% 257892-43-6 250mg $240 2026-06-04 Buy
Activate Scientific AS38657 tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate 97% 257892-43-6 1g $477 2026-06-04 Buy
aablocks AA00BIIO tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate 98% 257892-43-6 250mg $74 2026-05-28 Buy
aablocks AA00BIIO tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate 98% 257892-43-6 1g $174 2026-05-28 Buy
aablocks AA00BIIO tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate 98% 257892-43-6 5g $540 2026-05-28 Buy
Product number Packaging Price Buy
AS38657 250mg $240 Buy
AS38657 1g $477 Buy
AA00BIIO 250mg $74 Buy
AA00BIIO 1g $174 Buy
AA00BIIO 5g $540 Buy

(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester Chemical Properties,Uses,Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

Benzoylacetonitrile

614-16-4

(3-HYDROXY-3-PHENYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

257892-43-6

A tetrahydrofuran (100 mL) solution of 3-oxo-3-phenylpropionitrile (7.26 g, 50 mmol) was slowly added dropwise to an ice bath cooled 1.0 M lithium aluminum hydride tetrahydrofuran (100 mL) solution over 15 minutes. The reaction mixture was stirred at room temperature for 15 minutes, then warmed to 60 °C and continued stirring for 2 hours. Upon completion of the reaction, the mixture was cooled in an ice bath and the reaction was quenched sequentially by slow dropwise addition of water (3.8 mL), 4M sodium hydroxide solution (3.8 mL) and water (11.4 mL). After quenching, the mixture was continued to be stirred at room temperature for 20 min, after which the solid precipitate was removed by filtration and the solids were washed with tetrahydrofuran. The filtrate was mixed with di-tert-butyl dicarbonate (Boc2O, 13 g, 59.6 mmol) and stirred at room temperature overnight. The reaction solution was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to afford tert-butyl racemic (3-hydroxy-3-phenylpropyl)carbamate (yield 7.9 g, 62.9%) using hexane-ethyl acetate (70:30) as eluent.

References

[1] Patent: US2012/184548, 2012, A1. Location in patent: Page/Page column 12; 13

(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

2-methylpentane Di-tert-butyl dicarbonate Benzoylacetonitrile 3-Amino-1-phenyl-propan-1-ol Sodium hydroxide
Water Lithium Aluminum Hydride Tetrahydrofuran

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Preparation Products

(3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
SynAsst Chemical. 021-60343070 China 12731 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28763 58
Aikon International Limited 025-58859352 15955137747 sales01@aikonchem.com China 16021 58
Shanghai Baoyisheng Biotechnology Co., LTD 15221020695 ; 502277408@qq.com China 456 58
Zhejiang Lianshuo Biotechnology Co., Ltd. 18616526224 lianshuo@vip.126.com China 9605 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd 2383948258 19172820304 2383948258@qq.com China 12983 58
Qi Qi hang Biotechnology Co., Ltd. 15870833005 2232044025@qq.com China 8198 58
Supplier Advantage
SynAsst Chemical. 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
Amadis Chemical Company Limited 58
Amatek Scientific Co. Ltd. 58
Aikon International Limited 58
Shanghai Baoyisheng Biotechnology Co., LTD 58
Zhejiang Lianshuo Biotechnology Co., Ltd. 58
Energy Chemical 58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd 58
Qi Qi hang Biotechnology Co., Ltd. 58

257892-43-6((3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester)Related Search:

Hydroxypropyl cellulose 3-Hydroxy-N-methyl-3-phenyl-propylamine 3-Amino-1-phenyl-propan-1-ol (S)-tert-Butyl (3-hydroxy-3-phenylpropyl)carbaMate (R)-tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate
(R)-3-Amino-1-phenyl-propan-1-ol

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Tert-Butyl (3-hydroxy-3-phenylpropyl)carbaMate N-Boc-3-hydroxy-3-phenyl-1-propylamine Carbamic acid, N-(3-hydroxy-3-phenylpropyl)-, 1,1-dimethylethyl ester 3-(Boc-amino)-1-phenyl-1-propanol (3-Hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester 257892-43-6