3-Hydroxy-N-methyl-3-phenyl-propylamine
- CAS No.
- 42142-52-9
- Chemical Name:
- 3-Hydroxy-N-methyl-3-phenyl-propylamine
- Synonyms
- 3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL;3-METHYLAMINO-1-PHENYLPROPANOL;N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE;3-HYDROXY-N-METHYL-3-PHENYLPROPYLAMINE;α-[2-(Methylamino)ethyl]benzenemethanol;α-[2-(Methylamino)ethyl]benzenemethanol;α-[2-(MethyL;Compound PDK0217;Atomoxetine EP Imp H;Atomoxetine USP RC A
- CBNumber:
- CB6345561
- Molecular Formula:
- C10H15NO
- Molecular Weight:
- 165.23
- MDL Number:
- MFCD00674078
- MOL File:
- 42142-52-9.mol
- MSDS File:
- SDS
| Melting point | 64 °C |
|---|---|
| Boiling point | 170 °C / 31mmHg |
| Density | 1.017±0.06 g/cm3(Predicted) |
| vapor pressure | 0.037Pa at 25℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Soluble), Methanol (Slightly) |
| pka | 14.24±0.20(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| InChI | InChI=1S/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3 |
| InChIKey | XXSDCGNHLFVSET-UHFFFAOYSA-N |
| SMILES | C(C1C=CC=CC=1)(O)CCNC |
| LogP | 0.98 |
| CAS DataBase Reference | 42142-52-9(CAS DataBase Reference) |
| FDA UNII | I28ND993BO |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2922199695 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Hydroxy-N-methyl-3-phenyl-propylamine price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002201 | Fluoxetine impurity A CRS, European Pharmacopoeia (EP) Reference Standard | 42142-52-9 | 15 mg | $180 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2840 | Atomoxetine Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 42142-52-9 | 25MG | $665 | 2026-04-30 | Buy |
| Sigma-Aldrich | 463477 | α-[2-(Methylamino)ethyl]benzyl alcohol 97% | 42142-52-9 | 1g | $36.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1044470 | Atomoxetine Related Compound A United States Pharmacopeia (USP) Reference Standard | 42142-52-9 | 10mg | $1290 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0002201 | Fluoxetine impurity A CRS, European Pharmacopoeia (EP) Reference Standard | 42142-52-9 | Y0002201 | $156 | 2024-03-01 | Buy |
3-Hydroxy-N-methyl-3-phenyl-propylamine Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
3-Hydroxy-N-methyl-3-phenyl-propylamine is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.
Uses
α-[2-(Methylamino)ethyl]benzyl Alcohol (Fluoxetine EP Impurity A(Atomoxetine Related Compound A)) is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.This compound is found as an impurity in fluoxetine (F597100).
Synthesis
3-Hydroxy-N-methyl-3-phenyl-propylamine is one of important intermediate of preparation fluoxetine Hydrochloride. Up to now, the method for preparing N-methyl-3-phenyl-3-hydroxy-propylamine is mainly divided into three kinds; the first kind of be replace (halogen with 3-, dialkylamine, amido or ethoxycarbonyl) Propiophenone be starting raw material, earlier after reduction, the 1-phenylpropyl alcohol that 3-is replaced is converted into 3-Hydroxy-N-methyl-3-phenyl-propylamine again; Second kind and being: the different azoles alkane of 2-methyl-5-phenyl is carried out reductive ring open makes target compound; The third be: with getting the 1-phenylpropyl alcohol that 3-replaces behind epoxy styrene and the derivative reductive ring open thereof, be translated into target compound earlier.
References
[1] Patent: CN103992236, 2016, B. Location in patent: Paragraph 0051;0054; 0055
[2] Angewandte Chemie - International Edition, 2005, vol. 44, # 11, p. 1687 - 1689
3-Hydroxy-N-methyl-3-phenyl-propylamine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nordijia Biopharmaceutical (Suzhou) Co., Ltd. | 15150674956 | dannielee@nordicabio.com | China | 339 | 58 |
| Suzhou Yuanhuan Pharmaceutical Technology Co., Ltd. | 0512-18136053398 18136053398 | 2982784935@qq.com | China | 80 | 58 |
| Suzhou lipin Chemical Co., Ltd | 0512-67509664 19888480046 | 3516936381@qq.com | China | 111 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Lastest Price from 3-Hydroxy-N-methyl-3-phenyl-propylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-12 | 3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | 3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
|
$5.00 | 1kg | ≥99% | 50mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-11 | 3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
|
$66.00-99.00 | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- 3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
- $5.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- 3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
- $66.00-99.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
