ChemicalBook >> CAS DataBase List >>Edatrexate
Edatrexate
- CAS No.
- 80576-83-6
- Chemical Name:
- Edatrexate
- Synonyms
- EDX;CGP 30694;Edatrexate;NSC 626715;Ida Chusha;PSYLLIUMSEED;FSIRXIHZBIXHKT-MHTVFEQDSA-N;10-Ethyl-10-deazaaminopterin;10-Ethyl-10-deazaaminopterine;N-[4-[1-[(2,4-Diaminopteridin-6-yl)methyl]propyl]benzoyl]-L-glutamic acid
- CBNumber:
- CB7875719
- Molecular Formula:
- C22H25N7O5
- Molecular Weight:
- 467.48
- MDL Number:
- MFCD00866254
- MOL File:
- 80576-83-6.mol
- MSDS File:
- SDS
Last updated:2026-05-22 09:14:11
| Density | 1.441±0.06 g/cm3(Predicted) |
|---|---|
| pka | 3.56±0.10(Predicted) |
| NCI Dictionary of Cancer Terms | edatrexate |
| FDA UNII | JT4X6Z1HRR |
| NCI Drug Dictionary | edatrexate |
Edatrexate Chemical Properties, Uses, Production
Uses
Antineoplastic.
Definition
ChEBI: Edatrexate is a glutamic acid derivative.
in vivo
Edatrexate (0.14 g/kg and 0.21 g/kg; i.p.; twice weekly×3 or weekly×3) exerts potent efficacy against advanced metastatic disease in tumor-bearing mice, better than MTX[1].
| Animal Model: | Murine models of advanced metastatic disease (including E0771 mammary adenocarcinoma, T241 fibrosarcoma, Lewis lung carcinoma, B16 melanoma, or C38 colon carcinoma)[2] |
| Dosage: | 0.14 g/kg and 0.21 g/kg |
| Administration: | Intraperitoneal injection; 0.14 g/kg twice weekly for 3 weeks and 0.21 g/kg weekly for 3 weeks; added Ca leucovorin (LCV) 16, 20, 24 h after Edatrexate treatment |
| Result: | Increased survival of tumor-bearing mice. Showed markedly therapeutic effectiveness against advanced metastatic disease in high-dose regimen with delayed LCV rescue. |
Synthesis of Edatrexate from L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]propyl]benzoyl]-, diethyl ester (9CI)
Edatrexate Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 19)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29089 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| Supplier | Advantage |
|---|---|
| LGM Pharma | 70 |
| Dideu Industries Group Limited | 58 |
| BOC Sciences | 58 |
| SIMAGCHEM CORP | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
View Latest Price from Edatrexate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-21 | Edatrexate
80576-83-6
|
$3120.00-5000.00 | 10g | TargetMol Chemicals Inc. |
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- Edatrexate
80576-83-6
- $3120.00-5000.00
- TargetMol Chemicals Inc.
80576-83-6 (Edatrexate) Related Search:
1of4
(S)-2-[4-[1-[(2,4-Diaminopteridine-6-yl)methyl]propyl]benzoylamino]pentanedioic acid
10-Ethyl-10-deazaaminopterin
10-Ethyl-10-deazaaminopterine
EDX
N-[4-[1-[(2,4-Diaminopteridin-6-yl)methyl]propyl]benzoyl]-L-glutamic acid
CGP 30694
NSC 626715
FSIRXIHZBIXHKT-MHTVFEQDSA-N
Edatrexate
PSYLLIUMSEED
2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]pentanedioic acid
N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)propyl)benzoyl)-L-glutamic acid
L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]propyl]benzoyl]-
Ida Chusha
80576-83-6
C22H25N7O5
