2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
![2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Structure](CAS/20210305/GIF/2417718-25-1.gif)
- CAS No.
- 2417718-25-1
- Chemical Name:
- 2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
- Synonyms
- VT-104;VT104, 10 mM in DMSO;(S)-N-[1-(2-Pyridyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthamide;(S)-N-(1-(Pyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2-naphthamide;N-[(1S)-1-(pyridin-2-yl)ethyl]-5-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxamide;2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
- CBNumber:
- CB79021542
- Molecular Formula:
- C25H19F3N2O
- Molecular Weight:
- 420.43
- MDL Number:
- MOL File:
- 2417718-25-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 583.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.259±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear |
| form | Solid |
| pka | 13.30±0.46(Predicted) |
| color | White to off-white |
| InChI | 1S/C25H19F3N2O/c1-16(23-7-2-3-14-29-23)30-24(31)19-10-13-22-18(15-19)5-4-6-21(22)17-8-11-20(12-9-17)25(26,27)28/h2-16H,1H3,(H,30,31)/t16-/m0/s1 |
| InChIKey | AAZUPSFRSHFTGV-INIZCTEOSA-N |
| SMILES | FC(F)(C1=CC=C(C2=CC=CC3=CC(C(N[C@H](C4=NC=CC=C4)C)=O)=CC=C23)C=C1)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3445 | VT104 ≥98% (HPLC) | 2417718-25-1 | 5MG | $120 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3445 | VT104 ≥98% (HPLC) | 2417718-25-1 | 25MG | $484 | 2026-04-30 | Buy |
| Cayman Chemical | 45223 | VT104 ≥98% | 2417718-25-1 | 5mg | $85 | 2026-04-30 | Buy |
| Cayman Chemical | 45223 | VT104 ≥98% | 2417718-25-1 | 10mg | $136 | 2026-04-30 | Buy |
| Cayman Chemical | 45223 | VT104 ≥98% | 2417718-25-1 | 25mg | $234 | 2026-04-30 | Buy |
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Chemical Properties, Uses, Production
Description
VT-104 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT104 is an analog of VT102, which has improved potency and good oral pharmacokinetics in mice. VT104 prevented palmitoylation of the TEAD1 protein. VT104 showed excellent orally bioavailability and long half-lives, which inhibits tumor growth and also lead to shrinkage of established tumors in preclinical models of human mesothelioma CDX models deficient in functional Merlin.
Uses
VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer[1][2].
in vivo
VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts[1].
| Animal Model: | NCI-H226-tumor bearing mice[1] |
| Dosage: | 0.3, 1, and 3 mg/kg |
| Administration: | Oral administration |
| Result: | Blocked NCI-H226 tumor growth in mice in dose-dependent manner. |
References
[1] Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998. DOI:10.1158/1535-7163.MCT-20-0717
[2] Barry ER, et, al. Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine. Cells. 2021 Oct 11;10(10):2715. DOI:10.3390/cells10102715
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 1983 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2470 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1982 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
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