4-Chloro-6-hydroxyquinoline
- CAS No.
- 148018-29-5
- Chemical Name:
- 4-Chloro-6-hydroxyquinoline
- Synonyms
- 4-Chloroquinolin-6-ol;4-Chloro-6-quinolinol;6-Quinolinol, 4-chloro-;4-Chloro-6-hydroxyquinoline;4-chloroquinolin-6-ol - [C20033]
- CBNumber:
- CB7947809
- Molecular Formula:
- C9H6ClNO
- Molecular Weight:
- 179.6
- MDL Number:
- MFCD00456102
- MOL File:
- 148018-29-5.mol
- MSDS File:
- SDS
4-Chloro-6-hydroxyquinoline price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS110762 | 4-Chloro-6-hydroxyquinoline 97% | 148018-29-5 | 1g | $118 | 2026-06-04 | Buy |
| Activate Scientific | AS110762 | 4-Chloro-6-hydroxyquinoline 97% | 148018-29-5 | 5g | $530 | 2026-06-04 | Buy |
| Matrix Scientific | 310446 | 4-Chloro-6-hydroxyquinoline | 148018-29-5 | 250.00mg | $54 | 2026-05-19 | Buy |
| Matrix Scientific | 310446 | 4-Chloro-6-hydroxyquinoline | 148018-29-5 | 1.00g | $74 | 2026-05-19 | Buy |
| Matrix Scientific | 310446 | 4-Chloro-6-hydroxyquinoline | 148018-29-5 | 5.00g | $365 | 2026-05-19 | Buy |
4-Chloro-6-hydroxyquinoline Chemical Properties,Uses,Production
Synthesis
4295-04-9
148018-29-5
General procedure for the synthesis of 4-chloro-6-hydroxyquinoline from 4-chloro-6-methoxyquinoline: 1. Synthesis of 4-chloro-6-hydroxyquinoline: To a stirred solution of 4-chloro-6-methoxyquinoline (500 mg, 2.5 mmol) in dichloromethane (DCM, 10 mL) was added an aqueous solution of hydriodic acid (HI) (5 mL, 45%). The reaction mixture was heated to 100 °C and stirred for 5 hours. Upon completion of the reaction, the solution was cooled to room temperature and diluted by adding water (20 mL). The organic phase was separated, the aqueous phase was alkalized and extracted with dichloromethane (DCM, 30 mL x 3). The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated in vacuum to give 4-chloro-6-hydroxyquinoline (300 mg, 67% yield) as a white solid, which was used directly in the next step of the reaction. lc-MS (ESI) m/z = 180.3 ([M + H]+). 2. Synthesis of 2-((4-chloroquinolin-6-yl)oxy)acetonitrile: Bromoacetonitrile (240 mg, 2.0 mmol) and cesium carbonate (Cs2CO3, 350 mg, 2.5 mmol) were added to a solution of 4-chloro-6-hydroxyquinoline (300 mg, 1.7 mmol) obtained above in N,N-dimethylformamide (DMF, 10 mL). The reaction mixture was heated to 60 °C and stirred for 3 hours. After the reaction was completed, the solution was cooled to room temperature and diluted by adding water (50 mL). It was extracted with ethyl acetate (EtOAc, 50 mL x 3), and the organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated in vacuo to give 2-((4-chloroquinolin-6-yl)oxy)acetonitrile (300 mg, 81% yield) as an off-white solid. lc-MS (ESI) m/z = 219.1 ([M + H]+) . 3. The target product 30 was obtained as an off-white solid by using 2-((4-chloroquinolin-6-yl)oxy)acetonitrile in step 1 according to General Method A. 1H NMR (400 MHz, CD3OD) δ 8.49 (d, J = 4.9 Hz, 1H), 7.95 (d, J = 9.2 Hz, 1H), 7.65 (d, J = 2.8 Hz, 1H). 7.51 (dd, J = 9.2,3.0 Hz, 1H), 7.44 (d, J = 4.4 Hz, 1H), 5.20 (s, 2H), 2.97-3.02 (m, 2H), 2.27-2.41 (m, 3H), 2.05-2.08 (m, 1H).LC-MS (ESI) m/z = 313.1 ([M - H]-).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 2, p. 277 - 282
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 1659,1660
[3] Justus Liebigs Annalen der Chemie, 1950, vol. 568, p. 73,79
[4] Patent: US5506235, 1996, A
[5] Patent: KR2016/6207, 2016, A. Location in patent: Paragraph 0516; 0519-0522
4-Chloro-6-hydroxyquinoline Preparation Products And Raw materials
4-Chloro-6-hydroxyquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9980 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Lastest Price from 4-Chloro-6-hydroxyquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 4-Chloro-6-hydroxyquinoline
148018-29-5
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 4-Chloro-6-hydroxyquinoline
148018-29-5
- $9.80
- ≥99%
- Career Henan Chemical Co
148018-29-5(4-Chloro-6-hydroxyquinoline)Related Search:
1of4
