5,6-Difluoroindanone
- CAS No.
- 161712-77-2
- Chemical Name:
- 5,6-Difluoroindanone
- Synonyms
- 6-difluoro-2;6-Difluoroindanone;3-dihydroinden-1-one;5,6-Difluoroindanone;5,6-Difluoro-1-indanone;6-chloro-8-methoxythiochroman-4-one;5,6-difluoro-2,3-dihydroinden-1-one;1H-Inden-1-one, 5,6-difluoro-2,3-dihydro-
- CBNumber:
- CB7948200
- Molecular Formula:
- C9H6F2O
- Molecular Weight:
- 168.14
- MDL Number:
- MFCD07772125
- MOL File:
- 161712-77-2.mol
- MSDS File:
- SDS
| Boiling point | 251.3±40.0 °C(Predicted) |
|---|---|
| Density | 1.362±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | solid |
| color | White to light yellow |
| InChI | InChI=1S/C9H6F2O/c10-7-3-5-1-2-9(12)6(5)4-8(7)11/h3-4H,1-2H2 |
| InChIKey | OSJRTWXVMCRBKZ-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=C(F)C(F)=C2)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| TSCA | No |
| HS Code | 2914790090 |
5,6-Difluoroindanone price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC408504 | 5,6-Difluoro-2,3-dihydro-1H-inden-1-one >98% | 161712-77-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC408504 | 5,6-Difluoro-2,3-dihydro-1H-inden-1-one >98% | 161712-77-2 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC408504 | 5,6-Difluoro-2,3-dihydro-1H-inden-1-one >98% | 161712-77-2 | 5g | $62 | 2026-06-04 | Buy |
| Apolloscientific | PC408504 | 5,6-Difluoro-2,3-dihydro-1H-inden-1-one >98% | 161712-77-2 | 25g | $304 | 2026-06-04 | Buy |
| Apolloscientific | PC408504 | 5,6-Difluoro-2,3-dihydro-1H-inden-1-one >98% | 161712-77-2 | 100g | $942 | 2026-06-04 | Buy |
5,6-Difluoroindanone Chemical Properties,Uses,Production
Uses
5,6-Difluoro-1-indanone is a ketone organic compound that can be used as an organic reagent.
Synthesis
161712-76-1
161712-77-2
Step 2: To a carbon disulfide solution (300 mL) containing AlCl3 (76.4 g, 572.6 mmol) was added 3-(3,4-difluorophenyl)propionyl chloride (33.4 g, 163.6 mmol) to a carbon disulfide solution (120 mL) dropwise over 10 minutes at 0°C. The reaction mixture was stirred at 0°C for 30 minutes and then heated to reflux for 4 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was carefully poured onto crushed ice. The carbon disulfide layer was separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried with MgSO4 and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: 5-10% ethyl acetate/hexane) to afford 5,6-difluoro-2,3-dihydro-1H-inden-1-one 19.3 g (114.9 mmol, 70% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ ppm: 7.50 (t, 1H, J=8.0 Hz),. 7.24 (t, 1H, J=6.6Hz), 3.09 (t, 2H, J=5.5Hz), 2.72-2.69 (m, 2H).
References
[1] Patent: US2009/54431, 2009, A1. Location in patent: Page/Page column 40
[2] Patent: US2006/223830, 2006, A1. Location in patent: Page/Page column 40
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 602 - 606
[4] Patent: WO2015/88564, 2015, A1. Location in patent: Paragraph 00254
[5] Patent: CN102516115, 2016, B. Location in patent: Paragraph 0283; 0284
5,6-Difluoroindanone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Bingochem Co., Ltd. | 0571-87658025 | sales@bingochem.com | China | 21532 | 58 |
| Suzhou Xinghuo Biotechnology Co., Ltd. | 19945655289 17736114707 | xinghuoshengwu@163.com | China | 300 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuhan Luohua Medical Technology Co.,Ltd. | 13477084141; 13477084141 | sales@luohuapharm.com | China | 468 | 60 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
View Lastest Price from 5,6-Difluoroindanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-18 | 5,6-Difluoroindanone
161712-77-2
|
1KG | 98% | 1000 KG | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-01-03 | 5,6-Difluoroindanone
161712-77-2
|
$1.00 | 1KG | 99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 5,6-Difluoroindanone
161712-77-2
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5,6-Difluoroindanone
161712-77-2
- $1.00
- 99%
- Career Henan Chemical Co
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