Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>MS 154N

MS 154N

MS 154N Structure
MS 154N structure
CAS No.
2675490-97-6
Chemical Name:
MS 154N
Synonyms
MS 154N;1-Piperazinepropanamide, 4-[3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-N-[8-[[2,3-dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]oxy]octyl]-
CBNumber:
CB79510406
Molecular Formula:
C47H56ClFN8O8
Molecular Weight:
915.45
MDL Number:
MOL File:
2675490-97-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:52
Request For Quotation

MS 154N Properties

Boiling point 1038.552±65.00 °C(Press: 760.00 Torr)(predicted)
Density 1.316±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 16.258±0.46(predicted)
form Solid
color White to off-white

MS 154N price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0996163 MS154N 99.3% 2675490-97-6 1mg $368 2026-06-04 Buy
Tocris 7396 MS154N ≥98%(HPLC) 5 $345 2021-12-16 Buy
Product number Packaging Price Buy
CS-0996163 1mg $368 Buy
7396 5 $345 Buy

MS 154N Chemical Properties, Uses, Production

Uses

MS154N (compound 28) is the negative control of MS39 (HY-157581). MS154N is composed of PROTAC target protein ligand EGFR ligand-11 (HY-168305) (red part), E3 ligase ligand 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (HY-W441376) (blue part) and PROTAC Linker 8-Iodooctan-1-amine (HY-168306) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Me-Thalidomide-O-C8-NH2 (HY-168307)[1].

References

[1] Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63(3):1216-1232. DOI:10.1021/acs.jmedchem.9b01566

MS 154N Preparation Products And Raw materials

Raw materials

Preparation Products

MS 154N Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Guangzhou Younan Technology Co., Ltd 020-82000279 18988941452 YN_research@163.com China 2984 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Guangzhou Younan Technology Co., Ltd 58
TargetMol Chemicals Inc. 58

2675490-97-6 (MS 154N) Related Search:

dTAGV-1 EGFR Protein, HUMAN (621A.A, HEK293, FC) EGFR protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) HER2/CD340 protein, HUMAN (BIOTINYLATED, HEK293, HIS) HER3 Protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI)
AZD-9291

1of2

MS 154N 1-Piperazinepropanamide, 4-[3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-N-[8-[[2,3-dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]oxy]octyl]- 2675490-97-6