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4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine structure

CAS No.: 123066-64-8

Chemical Name:: 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine

Synonyms: CRAC 2;CRAC intermediate 2;CRAC intermediate 2, 10 mM in DMSO;4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline;4-(3,5-Bis(trifluoroMethyl)-1H-pyrazol-1-yl)aniline;4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine;Benzenamine, 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-;CRAC intermediate-2,Ca2+ release-activated Ca2+ channels,CRAC intermediate2,Inhibitor,CRAC Channel,CRAC intermediate 2,inhibit,Calcium release-activated channels

CBNumber:: CB7958425

Molecular Formula:: C11H7F6N3

Molecular Weight:: 295.18

MDL Number:: MFCD00220969

MOL File:: 123066-64-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-11 19:39:08

Product description	Number	Pack Size	Price
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine	072257	100.00mg	$83
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine	072257	250.00mg	$101
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine	072257	1.00g	$249
4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline 98+%	B72556	100mg	$200
4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline 98+%	B72556	250mg	$300

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4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Properties

Melting point	140-142 °C
Boiling point	298.4±40.0 °C(Predicted)
Density	1.52±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO : ≥ 52 mg/mL (176.16 mM)
form	Solid
pka	2.65±0.10(Predicted)
color	Light yellow to yellow

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	072257	4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine	123066-64-8	100.00mg	$83	2026-05-18	Buy
Matrix Scientific	072257	4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine	123066-64-8	250.00mg	$101	2026-05-18	Buy
Matrix Scientific	072257	4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine	123066-64-8	1.00g	$249	2026-05-18	Buy
Synthonix	B72556	4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline 98+%	123066-64-8	100mg	$200	2026-05-06	Buy
Synthonix	B72556	4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline 98+%	123066-64-8	250mg	$300	2026-05-06	Buy

Product number	Packaging	Price	Buy
072257	100.00mg	$83	Buy
072257	250.00mg	$101	Buy
072257	1.00g	$249	Buy
B72556	100mg	$200	Buy
B72556	250mg	$300	Buy

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Chemical Properties,Uses,Production

Uses

CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.

Synthesis

1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE

123066-63-7

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine

123066-64-8

Under hydrogen atmosphere, 1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (4.4 g, 13.5 mmol) was dissolved in EtOAc (44 mL) and Pd/C (1.3 g) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was vacuum filtered through a diatomaceous earth pad and the filter cake was washed with EtOAc. The filtrate was concentrated under reduced pressure to afford 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-aniline (compound 13) as a light yellow solid (3.75 g, 12.7 mmol, 94% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3) and mass spectrometry (MS): 1H-NMR δ 7.22 (d, J=8.5 Hz, 2H), 7.00 (s, 1H), 6.72 (d, J=8.5 Hz, 2H); MS m/z: [M+H]+ 296.

References

[1] Journal of Organic Chemistry, 2011, vol. 76, # 16, p. 6657 - 6669
[2] Patent: WO2017/212414, 2017, A1. Location in patent: Page/Page column 43
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 2975 - 2981

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Preparation Products And Raw materials

Raw materials

1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE Hydrogen Activated carbon Ethyl acetate Palladium

Preparation Products

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Suppliers

Global( 79)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58

Supplier	Advantage
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
BOC Sciences	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58

View Lastest Price from 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	CRAC intermediate 2 123066-64-8	$44.00-73.00		99.69%	10g	TargetMol Chemicals Inc.
2026-04-22	CRAC intermediate 2 123066-64-8	$44.00-73.00		99.69%	10g	TargetMol Chemicals Inc.
2019-12-26	4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine 123066-64-8	$1.00	1g	99%	200kg	Career Henan Chemical Co

CRAC intermediate 2
123066-64-8
$44.00-73.00
99.69%
TargetMol Chemicals Inc.

CRAC intermediate 2
123066-64-8
$44.00-73.00
99.69%
TargetMol Chemicals Inc.

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine
123066-64-8
$1.00
99%
Career Henan Chemical Co

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Spectrum

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine(123066-64-8)¹HNMR

123066-64-8(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine)Related Search:

2,3-Dichloro-5-(trifluoromethyl)pyridine 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride Inter-trifluoromethyl iodobenzene Trifluoromethanesulfonimide 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE

4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine BTP2 N1-(4-[3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]PHENYL)-2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-PENTADECAFLUOROOCTANAMIDE 2-AZIDO-N-[4-(3,5-(BIS-TRIFLUOROMETHYL)PYRAZOL-1-YL)PHENYL] BENZAMIDE, [AZIDOANTHRANILIC ACID RING-3H]-

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4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine 4-(3,5-Bis(trifluoroMethyl)-1H-pyrazol-1-yl)aniline CRAC intermediate 2 4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline CRAC 2 Benzenamine, 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]- CRAC intermediate-2,Ca2+ release-activated Ca2+ channels,CRAC intermediate2,Inhibitor,CRAC Channel,CRAC intermediate 2,inhibit,Calcium release-activated channels CRAC intermediate 2, 10 mM in DMSO 123066-64-8