BENZAMIL HYDROCHLORIDE
- CAS No.
- 161804-20-2
- Chemical Name:
- BENZAMIL HYDROCHLORIDE
- Synonyms
- Benzamil hydrochloride hydrate;Benzamil hydrate hydrochloride;Benzamil hydrochloride hydrate[B2417];Benzamil hydrochloride, Sodium channel blocker;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride;5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrate hydrochloride;3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide,hydrochloride;3;5-DIAMINO-6-CHLORO-N-[IMINO[(PHENYLMETHYL)AMINO]METHYL]-2-PYRAZINECARBOXAMIDE; MONOHYDROCHLORIDE
- CBNumber:
- CB7973022
- Molecular Formula:
- C13H15Cl2N7O
- Molecular Weight:
- 356.21
- MDL Number:
- MFCD00069219
- MOL File:
- 161804-20-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | methanol: soluble10mg/mL |
| form | solid |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or may be stored at -20°C for up to 3 months. |
| InChI | 1S/C13H14ClN7O.ClH.H2O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H;1H2 |
| InChIKey | YAJQRPFIYXRNKS-UHFFFAOYSA-N |
| SMILES | O.Cl.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)NCc2ccccc2 |
| FDA UNII | I7L324A070 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
BENZAMIL HYDROCHLORIDE price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B2417 | Benzamil hydrochloride hydrate ≥98% (HPLC) | 161804-20-2 | 10mg | $115 | 2026-04-30 | Buy |
| Sigma-Aldrich | B2417 | Benzamil hydrochloride hydrate ≥98% (HPLC) | 161804-20-2 | 50mg | $410 | 2026-04-30 | Buy |
| Cayman Chemical | 14313 | Benzamil (hydrochloride) ≥98% | 161804-20-2 | 5mg | $48 | 2026-04-30 | Buy |
| Cayman Chemical | 14313 | Benzamil (hydrochloride) ≥98% | 161804-20-2 | 10mg | $94 | 2026-04-30 | Buy |
| ChemScene | CS-7692 | Benzamil hydrochloride 99.70% | 161804-20-2 | 5mg | $65 | 2026-06-04 | Buy |
BENZAMIL HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Benzamil (161804-21-2) is a more potent (Ki = 10 nM vs 182 nM1, IC50 = 9 μM2) version of the epithelial sodium channel blocker Amiloride. It is also an inhibitor of Na+/Ca2+ exchange transport (IC50 = 11 μM)2 and the Na+/H+ antiporter (IC50 = 80 nM)2.
Uses
Benzamil Hydrochloride is a specific blocker of sodium channels. It also inhibits epithelial sodium channel (ENaC). Benzamil Hydrochloride is an analog of Amiloride (A578700).
Biochem/physiol Actions
Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels
storage
Store at +4°C
References
[1] A. W. CUTHBERT G. M F. EFFECTS OF SOME PYRAZINECARBOXAMIDES ON SODIUM TRANSPORT IN FROG SKIN[J]. British Journal of Pharmacology, 1978, 63 1: 139-149. DOI:10.1111/j.1476-5381.1978.tb07783.x
[2] T R KLEYMAN E J C. Amiloride and its analogs as tools in the study of ion transport.[J]. Journal of Membrane Biology, 1988, 105 1: 1-21. DOI:10.1007/bf01871102
BENZAMIL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2000 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Shanghai Resuperpharmtech Co., Ltd. | 02150565560; 17321237488 | kevin@resuperpharmtech.com | China | 353 | 58 |
| Heze Development Zone chuangli Chemical Co., Ltd. | 0530-+86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 849 | 55 |
View Lastest Price from BENZAMIL HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Benzamil hydrochloride
161804-20-2
|
$30.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2020-02-02 | BENZAMIL HYDROCHLORIDE
161804-20-2
|
$1.00 | 1KG | 99%HPLC | 200KG | Career Henan Chemical Co |
-
- Benzamil hydrochloride
161804-20-2
- $30.00
- TargetMol Chemicals Inc.
-
- BENZAMIL HYDROCHLORIDE
161804-20-2
- $1.00
- 99%HPLC
- Career Henan Chemical Co
