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ChemicalBook >> CAS DataBase List >>Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Structure
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- structure
CAS No.
294648-66-1
Chemical Name:
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-
Synonyms
ADAMTS-5-IN-2;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-
CBNumber:
CB810377352
Molecular Formula:
C17H15N3OS
Molecular Weight:
309.39
MDL Number:
MOL File:
294648-66-1.mol
MSDS File:
SDS
Last updated:2026-05-28 03:54:55
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Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Properties

Density 1.38±0.1 g/cm3(Predicted)
pka 0.54±0.20(Predicted)
form Solid
color Light yellow to brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0113838 ADAMTS-5-IN-2 98.73% 294648-66-1 5mg $260 2026-06-04 Buy
ChemScene CS-0113838 ADAMTS-5-IN-2 98.73% 294648-66-1 10mg $460 2026-06-04 Buy
ChemScene CS-0113838 ADAMTS-5-IN-2 98.73% 294648-66-1 25mg $861 2026-06-04 Buy
ChemScene CS-0113838 ADAMTS-5-IN-2 98.73% 294648-66-1 50mg $1376 2026-06-04 Buy
ChemScene CS-0113838 ADAMTS-5-IN-2 98.73% 294648-66-1 100mg $2199 2026-06-04 Buy
Product number Packaging Price Buy
CS-0113838 5mg $260 Buy
CS-0113838 10mg $460 Buy
CS-0113838 25mg $861 Buy
CS-0113838 50mg $1376 Buy
CS-0113838 100mg $2199 Buy

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Chemical Properties,Uses,Production

Uses

ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 μM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].

References

[1] Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74. DOI:10.1021/acscombsci.6b00033
[2] Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633.

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Anhui JYHX CO., LTD. 055167162561 13295518198 wangyanan@ahjyhx.com China 2044 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Anhui JYHX CO., LTD. 58
TargetMol Chemicals Inc. 58

View Lastest Price from Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ADAMTS-5-IN-2 pictures 2026-05-21 ADAMTS-5-IN-2
294648-66-1
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

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Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- ADAMTS-5-IN-2 294648-66-1