2-Chloro-3-iodopyridin-4-amine
- CAS No.
- 909036-46-0
- Chemical Name:
- 2-Chloro-3-iodopyridin-4-amine
- Synonyms
- 2-Chloro-3-iodo-4-pyridinamine;4-Amino-2-chloro-3-iodopyridine;2-Chloro-3-iodo-4-aminopyridine;oro-3-iodopyridin-4-amine;2-Chloro-3-iodopyridin-4-amine;2-Chloro-3-iodo-4-pyridylamine;2-CHL0R0-3-I0D0PYRIDIN-4- AMINE;4-PyridinaMine, 2-chloro-3-iodo-;4-Amino-2-chloro-3-iodopyridine,95%
- CBNumber:
- CB81229280
- Molecular Formula:
- C5H4ClIN2
- Molecular Weight:
- 254.46
- MDL Number:
- MFCD09763660
- MOL File:
- 909036-46-0.mol
- MSDS File:
- SDS
| Melting point | 116-117℃ |
|---|---|
| Boiling point | 377.0±42.0 °C(Predicted) |
| Density | 2.139±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 2.96±0.42(Predicted) |
| form | Solid |
| color | White to pink/orange |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C5H4ClIN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9) |
| InChIKey | BYVMKCHHWASQFN-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(N)=C1I |
| UNSPSC Code | 12352116 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H301-H311-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
2-Chloro-3-iodopyridin-4-amine price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000415 | 2-Chloro-3-iodopyridin-4-amine Aldrich | 909036-46-0 | 1g | $529 | 2026-04-30 | Buy |
| Activate Scientific | AS56687 | 2-Chloro-3-iodopyridin-4-amine 98% | 909036-46-0 | 1g | $28 | 2026-06-04 | Buy |
| Activate Scientific | AS56687 | 2-Chloro-3-iodopyridin-4-amine 98% | 909036-46-0 | 5g | $63 | 2026-06-04 | Buy |
| Activate Scientific | AS56687 | 2-Chloro-3-iodopyridin-4-amine 98% | 909036-46-0 | 25g | $239 | 2026-06-04 | Buy |
| Apolloscientific | OR42029 | 4-Amino-2-chloro-3-iodopyridine 95% | 909036-46-0 | 1g | $21 | 2026-06-04 | Buy |
2-Chloro-3-iodopyridin-4-amine Chemical Properties, Uses, Production
Uses
2-Chloro-3-iodo-4-pyridinamine can be used as a useful synthetic intermediate.
Synthesis
14432-12-3
909036-46-0
General procedure for the synthesis of 2-chloro-3-iodo-4-pyridinamine from 2-chloro-4-aminopyridine: To a 50 mL single-necked round-bottomed flask equipped with a magnetic stir bar, a reflux condenser tube, and a nitrogen inlet tube under nitrogen protection were added 2-chloro-4-aminopyridine (2.50 g, 19.4 mmol, 1.0 equiv.), sodium sulfate trihydrate (3.97 g, 29.2 mmol, 1.5 equiv.), iodine monochloride (3.47 g, 21.4 mmol, 1.1 equiv.) and glacial acetic acid (13.0 mL). 1.5 equiv), iodine monochloride (3.47 g, 21.4 mmol, 1.1 equiv) and glacial acetic acid (13.0 mL). The reaction mixture was heated at 70 °C and magnetically stirred for 16 hours. Complete consumption of the feedstock was confirmed by thin layer chromatography (TLC) and electron bombardment mass spectrometry (GC/MS-EI) analysis. Upon completion of the reaction, the mixture was cooled to room temperature and transferred to a dispensing funnel. Solid sodium bicarbonate (32.3 g) was carefully added in batches to quench the reaction, followed by water (75 mL) and ethyl acetate (75 mL). After complete release of the gas produced, the layers were left to stratify. The aqueous layer was separated and extracted with ethyl acetate (6 x 25 mL). All organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography with hexane/ethyl acetate as eluent (94:6 to 60:40 gradient elution) to afford 2-chloro-3-iodopyridin-4-amine as a light brown solid (2.21 g, 45% yield). The 1H NMR spectrum and low-resolution GC/MS (EI) mass spectrometry data of the product were consistent with those reported in the literature.
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 128, p. 202 - 212
[2] Patent: EP2526945, 2012, A1. Location in patent: Page/Page column 63
[3] Patent: WO2013/10880, 2013, A1. Location in patent: Page/Page column 94
[4] Patent: EP2548876, 2013, A1. Location in patent: Paragraph 0368; 0369
[5] Patent: WO2014/207260, 2014, A1. Location in patent: Page/Page column 78
2-Chloro-3-iodopyridin-4-amine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Liheng Biotechnology Co., Ltd. | 0531-18763987518 18763987518 | levi@lihengpharm.com | China | 1760 | 58 |
| Ningbo Zhenyue Pharmaceutical Technology Co., Ltd | 19817745290 | bd@blocksynth.com | China | 6406 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Fengcheng Meditech (Tianjin)Co., Ltd | 022-59002498-8008; 15122574756 | info@fcmeditech.com | China | 83 | 58 |
| Anhui Yongsheng Pharmaceutical Technology Co., Ltd | 3307 18017383231 | 983544897@qq.com | China | 942 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
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View Latest Price from 2-Chloro-3-iodopyridin-4-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Chloro-3-iodo-4-pyridinamine
909036-46-0
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2019-08-08 | 2-CHLORO-3-IODOPYRIDIN-4-AMINE
909036-46-0
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-Chloro-3-iodo-4-pyridinamine
909036-46-0
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2-CHLORO-3-IODOPYRIDIN-4-AMINE
909036-46-0
- $1.00
- 98%
- Career Henan Chemical Co
