Enclomiphene
- CAS No.
- 15690-57-0
- Chemical Name:
- Enclomiphene
- Synonyms
- Enclomifene;enclomiphene;trans-clomiphene;2-diphenylvinyl)phenoxy)-2-(p-(2-chloro-(e)-triethylamin;trans-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-n,n-diethylethanamine;ici46476;RMI 16,289;(E)-Clomiphene;E-CloMiphene-d4;trans-clomifene
- CBNumber:
- CB8128416
- Molecular Formula:
- C26H28ClNO
- Molecular Weight:
- 405.96
- MDL Number:
- MFCD08060098
- MOL File:
- 15690-57-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 149.0-150.5° |
|---|---|
| Boiling point | 509.0±50.0 °C(Predicted) |
| Density | 1.104±0.06 g/cm3(Predicted) |
| pka | 9.60±0.25(Predicted) |
| InChI | InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25+ |
| InChIKey | GKIRPKYJQBWNGO-OCEACIFDSA-N |
| SMILES | C(N(CC)CC)COC1=CC=C(/C(/C2=CC=CC=C2)=C(/Cl)\C2=CC=CC=C2)C=C1 |
| FDA UNII | R6D2UI4FLS |
Enclomiphene price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | QAA69057 | trans-Clomiphene | 15690-57-0 | 10g | $895.6 | 2026-06-04 | Buy |
| Biosynth | QAA69057 | trans-Clomiphene | 15690-57-0 | 25g | $1268.75 | 2026-06-04 | Buy |
| ChemScene | CS-0069846 | Enclomiphene 99.79% | 15690-57-0 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-0069846 | Enclomiphene 99.79% | 15690-57-0 | 10mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-0069846 | Enclomiphene 99.79% | 15690-57-0 | 25mg | $180 | 2026-06-04 | Buy |
Enclomiphene Chemical Properties, Uses, Production
Description
Enclomiphene is a synthetic and nonsteroidal antiestrogen. It is the more potent isomer and the one responsible for its ovulation-inducing actions. The half-life of enclomiphene is relatively short, so serum concentrations rise and fall quickly during and after treatment. Antiestrogens represent the first-line treatment strategy in WHO class-2 anovulatory infertility.
Uses
trans-Clomiphene is a Clomiphene (C587025) stereoisomer, a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. Treatment for infertility.
Definition
ChEBI: Clomiphene is a tertiary amine. It has a role as an estrogen antagonist and an estrogen receptor modulator. It derives from a hydride of a stilbene.
Preparation
CONDENSATION OF 4-HYDROXYBENZOPHENONE WITH 2-(DIETHYLAMINO)ETHYL CHLORIDE FOLLOWED BY TREATMENT WITH BENZYL MAGNESIUM CHLORIDE AND DEHYDRATION TO GIVE 2-(P-(1,2-DIPHENYLVINYL)PHENOXY)TRIETHYLAMINE WHICH IS CHLORINATED AND TREATED WITH CITRIC ACID /CITRATE/
Biological Activity
Enclomiphene is the trans-isomer of clomiphene citrate (CC). It has a higher rate of clearance and is less active than the cis-isomer, cis-clomiphene. Clomiphene citrate has been evaluated for antineoplastic activity against breast cancer.
Mode of action
Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. The main mechanism of its action is thought to be its antagonistic effects on the hypothalamic-pituitary axis and stimulation of GnRH secretion.
References
[1] SIMON HILL Richard Q Vijayaraman Arutchelvam. Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.[J]. Idrugs, 2009, 12 2: 109-119.
[2] KATHERINE M RODRIGUEZ Larry I L Alexander W Pastuszak. Enclomiphene citrate for the treatment of secondary male hypogonadism.[J]. Expert Opinion on Pharmacotherapy, 2016, 17 11: 1561-1567. DOI:10.1080/14656566.2016.1204294.
[3] JOSHUA A EARL Edward D K. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism.[J]. Expert Review of Endocrinology & Metabolism, 2019, 14 3: 157-165. DOI:10.1080/17446651.2019.1612239.
Enclomiphene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tenghua Tech | 13212769786 | 2024685872@qq.com | China | 139 | 58 |
| Hubei Awin Bio-Chemical Co., Ltd | 17362549610 | 312523773@qq.com | China | 115 | 58 |
| Henan Yinuokai New Materials Co., Ltd | 15764055027 15764055027 | 15764055027@163.com | China | 539 | 58 |
| Yunnan Huapai Pharmaceutical Technology Co., Ltd. | 18987811473 | 3100465655@qq.com | China | 26 | 58 |
| Shanghai Zhen Li Biological Technology Co., Ltd | 021-16621358918; 18516310516;16621358918;13045646768 | zhenlipharma888@163.com | China | 19060 | 58 |
| Jinan Jianfeng Chemical Co., Ltd. | 0531-88110457; 18954159893 | demi@pharmachemm.com | China | 205 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Hangzhou Dingyan Chem Co., LTD | 0571-87157530-8002 15267169049 | sales@dingyanchem.com | China | 2611 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7983 | 55 |
| Nanjing XiLang Chemical Products Co., Ltd. | 18936048580 | chemxilang@163.com | China | 3909 | 58 |
View Latest Price from Enclomiphene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Enclomiphene
15690-57-0
|
$5.00 | 1Box | 99.99% | 20000 boxes | Hebei Jiafan Trading Company Limited | |
 |
2026-09-15 | Enclomiphene
5990-43-9
|
$5.00 | 1g | 99% | 1000kg | Shanghai Zheng Peptide Plastic Co., Ltd. | |
 |
2026-09-15 | Androxal
15690-57-0
|
$10.00 | 1box | 99% | 100000box | Ningbo Qingteng Plastic Cost.,Ltd. |
-
- Enclomiphene
15690-57-0
- $5.00
- 99.99%
- Hebei Jiafan Trading Company Limited
-
- Enclomiphene
5990-43-9
- $5.00
- 99%
- Shanghai Zheng Peptide Plastic Co., Ltd.
-
- Androxal
15690-57-0
- $10.00
- 99%
- Ningbo Qingteng Plastic Cost.,Ltd.
