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2-Chloro-6-fluoroquinoline

2-Chloro-6-fluoroquinoline Structure
2-Chloro-6-fluoroquinoline structure
CAS No.
77119-53-0
Chemical Name:
2-Chloro-6-fluoroquinoline
Synonyms
2-Chloro-6-fluoroquinoline;6-FLUORO-2-CHLORO-QUINOLINE;Quinoline, 2-chloro-6-fluoro-;2-chloro-6-fluoro-quinoline - [C87398]
CBNumber:
CB8130488
Molecular Formula:
C9H5ClFN
Molecular Weight:
181.59
MDL Number:
MFCD08236768
MOL File:
77119-53-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:12
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2-Chloro-6-fluoroquinoline Properties

storage temp. Sealed in dry,2-8°C
form solid
color BROWN

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2933499090

2-Chloro-6-fluoroquinoline price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC404621 2-Chloro-6-fluoroquinoline >99% 77119-53-0 100mg $21 2026-06-04 Buy
Apolloscientific PC404621 2-Chloro-6-fluoroquinoline >99% 77119-53-0 250mg $24 2026-06-04 Buy
Apolloscientific PC404621 2-Chloro-6-fluoroquinoline >99% 77119-53-0 1g $66 2026-06-04 Buy
Apolloscientific PC404621 2-Chloro-6-fluoroquinoline >99% 77119-53-0 5g $323 2026-06-04 Buy
Apolloscientific PC404621 2-Chloro-6-fluoroquinoline >99% 77119-53-0 25g $1507 2026-06-04 Buy
Product number Packaging Price Buy
PC404621 100mg $21 Buy
PC404621 250mg $24 Buy
PC404621 1g $66 Buy
PC404621 5g $323 Buy
PC404621 25g $1507 Buy

2-Chloro-6-fluoroquinoline Chemical Properties, Uses, Production

Synthesis

6-FLUOROQUINOLIN-2(1H)-ONE

22614-75-1

2-CHLORO-6-FLUOROQUINOLINE

77119-53-0

6-Fluoro-1,2-dihydroquinolin-2-one (7.8 g, 47.8 mmol) was used as a raw material, which was suspended in phosphoryl chloride (72.2 g, 470.9 mmol) and the reaction was stirred at 100 °C in an oil bath for 4 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by vacuum concentration, followed by addition of ice water (200 ml) to the reaction mixture to quench the reaction. The resulting precipitate was washed with water (2 x 80 ml) and dried to afford 2-chloro-6-fluoroquinoline as an off-white solid (6.8 g, 78% yield). The product was confirmed by mass spectrometry (ES, m/z): [M + H]+ 182; 1H NMR (300 MHz, DMSO) data were as follows: δ 8.43 (d, J=8.4 Hz, 1H), 8.01 (dd, J=5.4 Hz, 9.3 Hz, 1H), 7.87 (dd, J=3.0 Hz, 9.3 Hz, 1H), 7.72-7.78 (m, 1H), 7.45 (d, J=8.4Hz, 1H).

References

[1] Patent: US2014/142114, 2014, A1. Location in patent: Paragraph 0448, 0449
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 22, p. 5405 - 5417

2-Chloro-6-fluoroquinoline Preparation Products And Raw materials

Raw materials

Quinoline, 6-fluoro-, 1-oxide 6-Fluoroquinolin-2(1H)-one

Preparation Products

2-Chloro-6-fluoroquinoline Suppliers

Global Suppliers ( 65)
Supplier Tel Email Country ProdList Advantage
Beijing Huaxing Research Technology Co., Ltd. 13263398295 15563557098 2885733844@qq.com China 84 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
SynAsst Chemical. 021-60343070 China 12731 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Worldyang Chemical Co.,Ltd. 021-56795766 sales@worldyachem.com China 9475 58
Suzhou Laing Biological Technology Co., LTD 0512-62968256 18550502935 export@laingbiotec.com China 994 58
Nantong Bosu Pharmaceutical Technology Co., Ltd. 0513-51005092; 15962844273 tashiyxy@163.com China 915 58
Mashilabs (Shanghai) Co.,Ltd. 19916721580 mafarm@126.com China 4534 58
Supplier Advantage
Beijing Huaxing Research Technology Co., Ltd. 58
Energy Chemical 61
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
SynAsst Chemical. 55
Bide Pharmatech Ltd. 60
Shanghai Worldyang Chemical Co.,Ltd. 58
Suzhou Laing Biological Technology Co., LTD 58
Nantong Bosu Pharmaceutical Technology Co., Ltd. 58
Mashilabs (Shanghai) Co.,Ltd. 58

View Latest Price from 2-Chloro-6-fluoroquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-6-fluoroquinoline pictures 2026-08-25 2-Chloro-6-fluoroquinoline
77119-53-0
 $1.10-9.90 1KG 99% min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-Chloro-6-fluoroquinoline Spectrum

2-CHLORO-6-FLUOROQUINOLINE(77119-53-0)1HNMR2-CHLORO-6-FLUOROQUINOLINE(77119-53-0)1HNMR2-CHLORO-6-FLUOROQUINOLINE(77119-53-0)19FNMR

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6-FLUORO-2-CHLORO-QUINOLINE Quinoline, 2-chloro-6-fluoro- 2-chloro-6-fluoro-quinoline - [C87398] 2-Chloro-6-fluoroquinoline 77119-53-0