Bifonazole
- CAS No.
- 60628-96-8
- Chemical Name:
- Bifonazole
- Synonyms
- mycospor;bifonazol;Bifonazole API;1[4,ALPHA-DIPHENYLBENZYL]-IMIDAZOLE;1-[phenyl-(4-phenylphenyl)-methyl]imidazole;1-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole;Amycor;Bedrid;A-One-L;Azolmen
- CBNumber:
- CB8138176
- Molecular Formula:
- C22H18N2
- Molecular Weight:
- 310.39
- MDL Number:
- MFCD00865567
- MOL File:
- 60628-96-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 142℃ |
|---|---|
| Boiling point | 440.55°C (rough estimate) |
| Density | 1.1150 (rough estimate) |
| refractive index | 1.7620 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO |
| form | powder |
| pka | 6.55±0.22(Predicted) |
| color | white to off-white |
| Merck | 14,1213 |
| Cosmetics Ingredients Functions |
ANTI-SEBORRHEIC ANTIMICROBIAL |
| InChI | InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H |
| InChIKey | OCAPBUJLXMYKEJ-UHFFFAOYSA-N |
| SMILES | C(C1C=CC=CC=1)(N1C=NC=C1)C1C=CC(C2C=CC=CC=2)=CC=1 |
| LogP | 4.770 |
| CAS DataBase Reference | 60628-96-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | QYJ305Z91O |
| ATC code | D01AC10,D01AC60 |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | NI3517000 | |||||||||
| HS Code | 29332900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter) | |||||||||
| NFPA 704 |
|
Bifonazole price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001421 | Bifonazole for system suitability European Pharmacopoeia (EP) Reference Standard | 60628-96-8 | 10 mg | $244 | 2026-04-30 | Buy |
| Sigma-Aldrich | B3563 | Bifonazole ≥98% (HPLC) | 60628-96-8 | 10mg | $59.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | B3563 | Bifonazole ≥98% (HPLC) | 60628-96-8 | 50mg | $229 | 2026-04-30 | Buy |
| Sigma-Aldrich | B1110000 | Bifonazole European Pharmacopoeia (EP) Reference Standard | 60628-96-8 | 50 mg | $170 | 2026-04-30 | Buy |
| TCI Chemical | B4173 | Bifonazole >98.0%(GC)(T) | 60628-96-8 | 1g | $34 | 2026-04-30 | Buy |
Bifonazole Chemical Properties, Uses, Production
Description
Bifonazole represents the first topical broad spectrum antimycotic approved for once daily administration. Its in vitro activity appears equivalent to its structural relative clotrimazole, being effective against dermatophytes, other filamentous fungi, dimorphic fungi and yeasts.
Description
Bifonazole is a topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria. It is effective in the treatment of experimental dermatophytic and Candida in animals. Bifonazole is also a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM, IC50 = 270 nM), which catalyzes the biosynthesis of estrogens from androgens. When applied topically in animals, it demonstrates prolonged retention time in skin with minimal percutaneous absorption, thus minimizing its effect on aromatase.
Chemical Properties
White or almost white, crystalline powder.
Originator
Bayer (W. Germany)
Uses
Bifonazole is an imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. Bifonazole is an inhibitor of C14orf1. Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and some gram-positive bacteria. Bifonazole inhibits ergosterol biosynthetic protein 28 and Cytochrome P450 2B4.
Uses
antibacterial
Definition
ChEBI: 1-[biphenyl-4-yl(phenyl)methyl]imidazole is a member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1. It is a member of imidazoles and a member of biphenyls.
Manufacturing Process
38.8g (0.15 mol) of 4-phenylbenzophenone are dissolved in 200 ml of ethanol
and 39 (0.075 mol) of sodium borohydride are added. After heating for 15
hours under reflux, and allowing to cool, the reaction mixture is hydrolyzed
with water containing a little hydrochloric acid. The solid thereby produced is
purified by recrystallization from ethanol. 36 g (89% of theory) of (biphenyl-
4-yl)-phenyl-carbinol [alternatively named as diphenyl-phenyl carbinol or α-
(biphenyl-4-yl)benzylalcohol] of melting point 72°-73°C are obtained.
13.6 g (0.2 mol) of imidazole are dissolved in 150 ml of acetonitrile and 3.5
ml of thionyl chloride are added at 10°C. 13 g (0.05 mol) of (biphenyl-4-yl)-
phenyl-carbinol are added to the solution of thionyl-bis-imidazole thus
obtained. After standing for 15 hours at room temperature, the solvent is
removed by distillation in vacuo. The residue is taken up in chloroform and
the solution is washed with water. The organic phase is collected, dried over
sodium sulfate and filtered and the solvent is distilled off in vacuo. The oily
residue is dissolved in ethyl acetate and freed from insoluble, resinous
constituents by filtration. The solvent is again distilled off in vacuo and the
residue is purified by recrystallization from acetonitrile, 8.7 g (56% of theory)
of (biphenyl-4-yl)-imidazol-1-yl-phenylmethane [alternatively named as
diphenyl-imidazolyl-(1)-phenyl-methane or as 1-(α-biphenyl-4-
ylbenzyl)imidazole] of melting point 142°C are obtained.
brand name
Mycospor (Bayer).
Therapeutic Function
Antifungal
References
[1] T E LACKNER S P C. Bifonazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses.[J]. Drugs, 1989, 38 2: 204-225. DOI: 10.2165/00003495-198938020-00004
[2] FROMTLING R A. Overview of medically important antifungal azole derivatives.[J]. Clinical Microbiology Reviews, 1988, 1 2: 187-217. DOI: 10.1128/cmr.1.2.187
[3] CHINAZA EGBUTA Debashis G Jessica Lo. Mechanism of inhibition of estrogen biosynthesis by azole fungicides.[J]. Endocrinology, 2014, 155 12: 4622-4628. DOI: 10.1210/en.2014-1561
Bifonazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Zenuo Biopharmaceutical Technology Co., Ltd | 027-87781970 15172508891 | 1505560767@qq.com | China | 132 | 58 |
| WUHAN MEIAN BIOMEDICINE TECHNOLOGY Co., Ltd， | 15377551262 | 180953430@qq.com | China | 165 | 58 |
| Wuhan Linglingjiu Biotechnology Co., Ltd | 15623309010 | 1287744812@qq.com | China | 960 | 58 |
| Zhongshan Wanhan Pharmaceuticals Co., Ltd. | 4008930086 13823019268 | bingying_he@whpt.com.cn | China | 15 | 58 |
| Guangzhou Hanfang Pharmaceutical Company Limited | 02084484289 18575889543 | 824592739@qq.com | China | 20 | 58 |
| XI'AN RONGBAI BIOTECHNOLOGY CO., LTD. | 029-81629930 18165286873 | rb@xarbkj.com | China | 348 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
Related articles
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- Bifonazoleis a imidazole antimycotic bifonazole used to treat mycoses of the skin induced or sustained by fungi such as dermat....
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View Latest Price from Bifonazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | Bifonazole
60628-96-8
|
1KG | 98%-100.5% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Bifonazole
60628-96-8
|
$2.00-10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-29 | Bifonazole
60628-96-8
|
$31.00 | 99.88% | 10g | TargetMol Chemicals Inc. |
-
- Bifonazole
60628-96-8
- $0.00
- 98%-100.5%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Bifonazole
60628-96-8
- $2.00-10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Bifonazole
60628-96-8
- $31.00
- 99.88%
- TargetMol Chemicals Inc.
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