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Bifonazole

Bifonazole Structure
Bifonazole structure
CAS No.
60628-96-8
Chemical Name:
Bifonazole
Synonyms
mycospor;bifonazol;1-[phenyl-(4-phenylphenyl)-methyl]imidazole;Amycor;Bedrid;A-One-L;Azolmen;Bedriol;Bifazol;bayh4502
CBNumber:
CB8138176
Molecular Formula:
C22H18N2
Molecular Weight:
310.39
MDL Number:
MFCD00865567
MOL File:
60628-96-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
Bifonazole for system suitability European Pharmacopoeia (EP) Reference Standard Y0001421 10 mg $244
Bifonazole ≥98% (HPLC) B3563 10mg $59.9
Bifonazole ≥98% (HPLC) B3563 50mg $229
Bifonazole European Pharmacopoeia (EP) Reference Standard B1110000 50 mg $170
Bifonazole >98.0%(GC)(T) B4173 1g $34
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Bifonazole Properties

Melting point 142℃
Boiling point 440.55°C (rough estimate)
Density 1.1150 (rough estimate)
refractive index 1.7620 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO
pka 6.55±0.22(Predicted)
form powder
color white to off-white
Merck 14,1213
Cosmetics Ingredients Functions ANTI-SEBORRHEIC
ANTIMICROBIAL
InChI InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H
InChIKey OCAPBUJLXMYKEJ-UHFFFAOYSA-N
SMILES C(C1C=CC=CC=1)(N1C=NC=C1)C1C=CC(C2C=CC=CC=2)=CC=1
LogP 4.770
CAS DataBase Reference 60628-96-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII QYJ305Z91O
ATC code D01AC10,D01AC60
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
WGK Germany  1
RTECS  NI3517000
HS Code  29332900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Toxicity LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter)
NFPA 704
0
1 0

Bifonazole price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001421 Bifonazole for system suitability European Pharmacopoeia (EP) Reference Standard 60628-96-8 10 mg $244 2026-03-19 Buy
Sigma-Aldrich B3563 Bifonazole ≥98% (HPLC) 60628-96-8 10mg $59.9 2026-03-19 Buy
Sigma-Aldrich B3563 Bifonazole ≥98% (HPLC) 60628-96-8 50mg $229 2026-03-19 Buy
Sigma-Aldrich B1110000 Bifonazole European Pharmacopoeia (EP) Reference Standard 60628-96-8 50 mg $170 2026-03-19 Buy
TCI Chemical B4173 Bifonazole >98.0%(GC)(T) 60628-96-8 1g $34 2026-03-19 Buy
Product number Packaging Price Buy
Y0001421 10 mg $244 Buy
B3563 10mg $59.9 Buy
B3563 50mg $229 Buy
B1110000 50 mg $170 Buy
B4173 1g $34 Buy

Bifonazole Chemical Properties,Uses,Production

Description

Bifonazole represents the first topical broad spectrum antimycotic approved for once daily administration. Its in vitro activity appears equivalent to its structural relative clotrimazole, being effective against dermatophytes, other filamentous fungi, dimorphic fungi and yeasts.

Description

Bifonazole is a topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria. It is effective in the treatment of experimental dermatophytic and Candida in animals. Bifonazole is also a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM, IC50 = 270 nM), which catalyzes the biosynthesis of estrogens from androgens. When applied topically in animals, it demonstrates prolonged retention time in skin with minimal percutaneous absorption, thus minimizing its effect on aromatase.

Chemical Properties

White or almost white, crystalline powder.

Originator

Bayer (W. Germany)

Uses

Bifonazole is an imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. Bifonazole is an inhibitor of C14orf1. Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and some gram-positive bacteria. Bifonazole inhibits ergosterol biosynthetic protein 28 and Cytochrome P450 2B4.

Uses

antibacterial

Definition

ChEBI: 1-[biphenyl-4-yl(phenyl)methyl]imidazole is a member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1. It is a member of imidazoles and a member of biphenyls.

Manufacturing Process

38.8g (0.15 mol) of 4-phenylbenzophenone are dissolved in 200 ml of ethanol and 39 (0.075 mol) of sodium borohydride are added. After heating for 15 hours under reflux, and allowing to cool, the reaction mixture is hydrolyzed with water containing a little hydrochloric acid. The solid thereby produced is purified by recrystallization from ethanol. 36 g (89% of theory) of (biphenyl- 4-yl)-phenyl-carbinol [alternatively named as diphenyl-phenyl carbinol or α- (biphenyl-4-yl)benzylalcohol] of melting point 72°-73°C are obtained.
13.6 g (0.2 mol) of imidazole are dissolved in 150 ml of acetonitrile and 3.5 ml of thionyl chloride are added at 10°C. 13 g (0.05 mol) of (biphenyl-4-yl)- phenyl-carbinol are added to the solution of thionyl-bis-imidazole thus obtained. After standing for 15 hours at room temperature, the solvent is removed by distillation in vacuo. The residue is taken up in chloroform and the solution is washed with water. The organic phase is collected, dried over sodium sulfate and filtered and the solvent is distilled off in vacuo. The oily residue is dissolved in ethyl acetate and freed from insoluble, resinous constituents by filtration. The solvent is again distilled off in vacuo and the residue is purified by recrystallization from acetonitrile, 8.7 g (56% of theory) of (biphenyl-4-yl)-imidazol-1-yl-phenylmethane [alternatively named as diphenyl-imidazolyl-(1)-phenyl-methane or as 1-(α-biphenyl-4- ylbenzyl)imidazole] of melting point 142°C are obtained.

brand name

Mycospor (Bayer).

Therapeutic Function

Antifungal

References

[1] T E LACKNER  S P C. Bifonazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses.[J]. Drugs, 1989, 38 2: 204-225. DOI: 10.2165/00003495-198938020-00004
[2] FROMTLING R A. Overview of medically important antifungal azole derivatives.[J]. Clinical Microbiology Reviews, 1988, 1 2: 187-217. DOI: 10.1128/cmr.1.2.187
[3] CHINAZA EGBUTA  Debashis G  Jessica Lo. Mechanism of inhibition of estrogen biosynthesis by azole fungicides.[J]. Endocrinology, 2014, 155 12: 4622-4628. DOI: 10.1210/en.2014-1561

Bifonazole synthesis

288-32-4
613-42-3
60628-96-8
Synthesis of Bifonazole from Imidazole and 4-BENZYLBIPHENYL

Bifonazole Preparation Products And Raw materials

Raw materials

Biphenyl 2,2'-Bis(2-chlorophenyl)-4,4',5,5'-tetraphenyl-1,2'-biimidazole Thionyl chloride Imidazole Sodium borohydride
4-Benzoylbiphenyl alpha-phenyl[1,1'-biphenyl]-4-methanol 4-(chlorophenylmethyl)-1,1'-biphenyl 4-BENZYLBIPHENYL 4-BENZYLANILINE
PHENYLTRIMETHYLSILANE

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Preparation Products

Bifonazole Suppliers

Global( 497)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5974 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
airuikechemical co., ltd. 		+86-18353166132 sales02@airuikechemical.com China 983 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		+15184799099 lbaochemicals@gmail.com China 671 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21591 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
airuikechemical co., ltd. 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55

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View Lastest Price from Bifonazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bifonazole pictures 2026-04-30 Bifonazole
60628-96-8
 US $0.00 / Kg/Drum 1KG 98%-100.5% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Bifonazole pictures 2026-04-29 Bifonazole
60628-96-8
 US $0.00 / kg 1kg 98% Customise Hefei Lbao Physical & Chemical Science Co.,Ltd
Bifonazole pictures 2026-04-24 Bifonazole
60628-96-8
 US $225.00 / KG 1KG 98% 1-20mt Baoji Guokang Healthchem Co., Ltd.
  • Bifonazole pictures
  • Bifonazole
    60628-96-8
  • US $0.00 / Kg/Drum
  • 98%-100.5%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Bifonazole pictures
  • Bifonazole
    60628-96-8
  • US $0.00 / kg
  • 98%
  • Hefei Lbao Physical & Chemical Science Co.,Ltd
  • Bifonazole pictures
  • Bifonazole
    60628-96-8
  • US $225.00 / KG
  • 98%
  • Baoji Guokang Healthchem Co., Ltd.

Bifonazole Spectrum

Bifonazole(60628-96-8)1HNMR

60628-96-8(Bifonazole)Related Search:

FIREMASTER BP-6 Imidazole Benzyltriethylammonium chloride 5-Chlorovaleric acid GHRP-2
DL-α-Tocopherol Bensulfuron methyl Bifendate trans-Bifenthtin Methylparaben
PHENYL VALERATE Methyl acrylate 4-(Diethylamino)salicylaldehyde Diphenolic acid Kresoxim-methyl
Thiophanate-methyl 2,3,3',4,4',5-HEXACHLOROBIPHENYL 1H-Imidazole, 4-([1,1'-biphenyl]-4-ylphenylmethyl)-

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Bifonazole for system suitability Bifonazole Impurity bifonazol Biphenylylbenzylazole trifonazole 1-[phenyl-(4-phenylphenyl)-methyl]imidazole 1-[P,ALPHA-DIPHENYLBENZYL]IMIDAZOLE 1[4,ALPHA-DIPHENYLBENZYL]-IMIDAZOLE BIFONAZOLE 1-(p,α-diphenylbenzyl)imidazole BIFONAZOLE(PATENT-NOSUPPLY) 1-[α-(4-biphenyl)benzyl]-1H-imidazole 1H-Imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)- Amycor A-One-L Azolmen Bedriol Bifazol mycospor 1-((1,1’-biphenyl)-4-ylphenylmethyl)-1h-imidazol 1-((4-biphenylyl)phenylmethyl)-1h-imidazole 1-(alpha-(4-biphenylyl)benzyl)-imidazol 1-(alpha-(4-biphenylyl)benzyl)imidazole 1-[(1,1’-biphenyl)-4-ylphenylmethyl]-1H-Imidazole bayh4502 Mycosporan Bedrid 1-[α-(4-Biphenylyl)benzyl]-1H-imidazole Bifonazole API Bifonazole, >=98% (HPLC) 1-(Biphenyl-4-yl(Phenyl)Methyl)-1H-Imidazole Naftifine hydrochloride Solution, 100ppm Bifonazole > Bifonazole for system suitability CRS Bifonazole CRS 1-(alpha,4-Diphenylbenzyl)imidazole Bifonazole USP/EP/BP BifonazoleQ: What is Bifonazole Q: What is the CAS Number of Bifonazole Q: What is the storage condition of Bifonazole Q: What are the applications of Bifonazole Bifonazole,NA,Pregabalin 1-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole (¨¤)-Bifonazo Bibenzazole Bifonazole, 10 mM in DMSO Bifonazole - Bio-X ? Bifonazole (Bay H-4502) (±)-Bifonazole Bifoazole SGLT2 Inhibitor Precursor (Pediatric) Anti-Dengue Virus Intermediate SGLT2 Inhibitor Intermediate (Combination) Feline Bifonazole Intermediate Feline Bifonazole Hydrochloride Intermediate 60628-96-8 API SARAFLOX