PPARδ agonist 11

PPARδ agonist 11 structure

CAS No.: 2982696-04-6

Chemical Name:: PPARδ agonist 11

Synonyms: PPARδ agonist 11;Acetic acid, 2-[2-methyl-4-[[[5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl]methyl]thio]phenoxy]-

CBNumber:: CB814907784

Molecular Formula:: C19H15F3N2O3S2

Molecular Weight:: 440.46

MDL Number:

MOL File:: 2982696-04-6.mol

MSDS File:: SDS

Last updated:2026-05-28 03:58:59

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PPARδ agonist 11 Properties

Boiling point	570.9±60.0 °C(predicted)
Density	1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	3.16±0.10(predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

PPARδ agonist 11 Chemical Properties, Uses, Production

Uses

PPARδ agonist 11 (Compound 11) is a selective agonist for PPARδ with an EC50 of 20 nM. PPARδ agonist 11 reduces the levels of nitrite oxide (NO), proinflammatory cytokines TNFα and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 cell, and exhibits anti-inflammatory efficacy via NF-κB pathway. PPARδ agonist 11 exhibits good stability in human liver microsomes and plasma. PPARδ agonist 11 ameliorates Carrageenan (HY-125474)-induced foot edema[1].

IC 50

hPPARδ: 0.02 μM (EC₅₀); hPPARα: 8 μM (EC₅₀)

References

[1] Kim J, et al., Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders. Eur J Med Chem. 2024 Sep 12;279:116856. DOI:10.1016/j.ejmech.2024.116856

PPARδ agonist 11 Preparation Products And Raw materials

Raw materials

Preparation Products

PPARδ agonist 11 Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2982696-04-6 (PPARδ agonist 11) Related Search:

PPARδ agonist 11 Acetic acid, 2-[2-methyl-4-[[[5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl]methyl]thio]phenoxy]- CD40 Protein, HUMAN (HEK293, FC) TRAIL R1/TNFRSF10A protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) TRAIL R2/TNFRSF10B Protein, HUMAN (127A.A, HEK293, HIS)

CD40 Protein, Human (HEK293, His)

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PPARδ agonist 11 Acetic acid, 2-[2-methyl-4-[[[5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl]methyl]thio]phenoxy]- 2982696-04-6