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tert-Butyl (4-methylpiperidin-4-yl)carbamate

tert-Butyl (4-methylpiperidin-4-yl)carbamate Structure
tert-Butyl (4-methylpiperidin-4-yl)carbamate structure
CAS No.
163271-08-7
Chemical Name:
tert-Butyl (4-methylpiperidin-4-yl)carbamate
Synonyms
4-(Boc-amino)-4-methylpip...;4-Methylpiperidin-4-yl)carbami;4-(Boc-aMino)-4-Methylpiperidine;tert-Butyl (4-methylpiperidin-4-yl);4-Amino-4-methylpiperidine, 4-BOC protected;tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate;tert-Butyl (4-methylpiperidin-4-yl)carbamate;tert-Butyl (4-methyl-4-piperidinyl)carbamate;tert-butyl N-(4-methylpiperidin-4-yl)carbamate;N-(4-Methylpiperidin-1-yl)(tert-butoxy)forMaMide
CBNumber:
CB81501982
Molecular Formula:
C11H22N2O2
Molecular Weight:
214.3
MDL Number:
MFCD08703167
MOL File:
163271-08-7.mol
MSDS File:
SDS
Last updated:2026-05-28 04:17:17
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tert-Butyl (4-methylpiperidin-4-yl)carbamate Properties

Boiling point 308 °C
Density 1.01
Flash point 140 °C
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 12.75±0.20(Predicted)
form powder
color Gray
InChI InChI=1S/C11H22N2O2/c1-10(2,3)15-9(14)13-11(4)5-7-12-8-6-11/h12H,5-8H2,1-4H3,(H,13,14)
InChIKey MVUNGZMGWJXPIM-UHFFFAOYSA-N
SMILES C(OC(C)(C)C)(=O)NC1(C)CCNCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P280
HS Code  2933399990

tert-Butyl (4-methylpiperidin-4-yl)carbamate price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D6495 tert-Butyl (4-Methylpiperidin-4-yl)carbamate min. 98.0 % 163271-08-7 1G $56 2026-04-30 Buy
TCI Chemical D6495 tert-Butyl (4-Methylpiperidin-4-yl)carbamate min. 98.0 % 163271-08-7 5G $168 2026-04-30 Buy
Apolloscientific OR308121 4-Amino-4-methylpiperidine, 4-BOC protected 95% 163271-08-7 1g $21 2026-06-04 Buy
Apolloscientific OR308121 4-Amino-4-methylpiperidine, 4-BOC protected 95% 163271-08-7 5g $54 2026-06-04 Buy
Apolloscientific OR308121 4-Amino-4-methylpiperidine, 4-BOC protected 95% 163271-08-7 25g $204 2026-06-04 Buy
Product number Packaging Price Buy
D6495 1G $56 Buy
D6495 5G $168 Buy
OR308121 1g $21 Buy
OR308121 5g $54 Buy
OR308121 25g $204 Buy

tert-Butyl (4-methylpiperidin-4-yl)carbamate Chemical Properties, Uses, Production

Uses

tert-Butyl (4-methylpiperidin-4-yl)carbamate is versatile intermediates in organic synthesis, particularly in the pharmaceutical industry. They are used in the synthesis of various compounds, including natural products and potential therapeutic agents. 

Synthesis

tert-butyl 1-benzoyl-4-methylpiperidin-4-ylcarbamate

1262787-56-3

tert-Butyl (4-methylpiperidin-4-yl)carbamate

163271-08-7

General procedure for the synthesis of tert-butyl (4-methylpiperidin-4-yl)carbamate from (1-benzoyl-4-methylpiperidin-4-yl)carbamate: 1. tert-Butyl (1-benzoyl-4-methylpiperidin-4-yl)carbamate (318 mg, 1.0 mmol) was dissolved in ethanol (3 mL). 2. 6 N aqueous sodium hydroxide (1.0 mL, 6.0 mmol) was added to the above solution. 3. The reaction mixture was heated at reflux for 8 hours. 4. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure. 5. Ethyl acetate (30 mL) was added to the concentrated mixture. 6. The organic layer was separated and washed twice with distilled water. 7. Dry the organic layer with anhydrous magnesium sulfate. 8. Concentrate the dried organic layer under reduced pressure and dry under reduced pressure to afford the target product tert-butyl (4-methylpiperidin-4-yl)carbamate (145 mg, 0.67 mmol, 67% yield). Characterization data: Mass spectrum (EI, m/z): 214 [M]+. 1H-NMR (CDCl3) δ: 4.37 (1H, br s), 2.84-2.80 (4H, m), 1.91 (2H, dt, J = 13.3, 3.9 Hz), 1.51 (2H, td, J = 12.9, 6.2 Hz), 1.44 (9H, s), 1.34 (3H, s).

References

[1] Patent: US2012/149902, 2012, A1. Location in patent: Page/Page column 24

tert-Butyl (4-methylpiperidin-4-yl)carbamate Preparation Products And Raw materials

Raw materials

tert-butyl 1-benzoyl-4-methylpiperidin-4-ylcarbamate Water Sodium hydroxide Ethanol

Preparation Products

tert-Butyl (4-methylpiperidin-4-yl)carbamate Suppliers

Global Suppliers ( 161)
Supplier Tel Email Country ProdList Advantage
Aikon International Limited 025-58859352 19370895928 sales01@aikonchem.com China 15078 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Dtchem Laboratories,（Gan Su）Co.,Ltd. 18993961550 18993966060 sales@techbiochem.com China 773 61
Supplier Advantage
Aikon International Limited 58
Shanghai Boyle Chemical Co., Ltd. 55
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Ennopharm Co., Ltd. 65
T&W GROUP 58
Dtchem Laboratories,（Gan Su）Co.,Ltd. 61

View Latest Price from tert-Butyl (4-methylpiperidin-4-yl)carbamate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl (4-methylpiperidin-4-yl)carbamate pictures 2022-02-25 tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
 $100.00 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
tert-Butyl (4-methylpiperidin-4-yl)carbamate pictures 2022-02-25 tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
 $100.00 1KG 98% 10KG Hong Kong Tiansheng New Material Trading Co., Ltd
tert-Butyl (4-methylpiperidin-4-yl)carbamate pictures 2019-07-06 tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
 $1.00 1KG 99% 20kg Career Henan Chemical Co

tert-Butyl (4-methylpiperidin-4-yl)carbamate Spectrum

tert-Butyl (4-methylpiperidin-4-yl)carbamate(163271-08-7)1HNMR

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4-Methylpiperidin-4-yl)carbami (4-Methylpiperidin-4-yl)carbamic acid tert-butyl ester tert-Butyl (4-methyl-4-piperidinyl)carbamate (4-Methylpiperidin-4-yl)carbamic acid 1,1-dimethylethyl ester tert-Butyl (4-methylpiperidin-4-yl)carbamate 4-(Boc-amino)-4-methylpip... 4-(Boc-aMino)-4-Methylpiperidine tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate N-(4-Methylpiperidin-1-yl)(tert-butoxy)forMaMide 4-Amino-4-methylpiperidine, 4-BOC protected tert-Butyl (4-methylpiperidin-4-yl)carbamate, 4-[(tert-Butoxycarbonyl)amino]-4-methylpiperidine CarbaMic acid, N-(4-Methyl-4-piperidinyl)-, 1,1-diMethylethyl ester tert-butyl N-(4-methylpiperidin-4-yl)carbamate tert-Butyl (4-methylpiperidin-4-yl) 1,1-Dimethylethyl N-(4-methyl-4-piperidinyl)carbamate 163271-08-7 API intermediates