2-Iodo-3-methoxyaniline
- CAS No.
- 98991-09-4
- Chemical Name:
- 2-Iodo-3-methoxyaniline
- Synonyms
- 3-Amino-2-iodoanisole;2-Iodo-3-methoxyaniline;2-Iodo-3-methoxy-phenylamine;2-iodo-3-methoxybenzeneamine;Benzenamine, 2-iodo-3-methoxy-;3-AMino-2-iodoanisole[2-Iodo-3-Methoxyaniline]
- CBNumber:
- CB81568792
- Molecular Formula:
- C7H8INO
- Molecular Weight:
- 249.05
- MDL Number:
- MFCD11848601
- MOL File:
- 98991-09-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
2-Iodo-3-methoxyaniline price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS141155 | 2-Iodo-3-methoxyaniline 95% | 98991-09-4 | 1g | $101 | 2026-06-04 | Buy |
| Activate Scientific | AS141155 | 2-Iodo-3-methoxyaniline 95% | 98991-09-4 | 5g | $408 | 2026-06-04 | Buy |
| Activate Scientific | AS141155 | 2-Iodo-3-methoxyaniline 95% | 98991-09-4 | 25g | $1620 | 2026-06-04 | Buy |
| Matrix Scientific | 303503 | 2-Iodo-3-methoxyaniline | 98991-09-4 | 1.00g | $63 | 2026-05-19 | Buy |
| Matrix Scientific | 303503 | 2-Iodo-3-methoxyaniline | 98991-09-4 | 5.00g | $261 | 2026-05-19 | Buy |
2-Iodo-3-methoxyaniline Chemical Properties, Uses, Production
Synthesis
194869-14-2
98991-09-4
The general procedure for the synthesis of 2-iodo-3-methoxyaniline from the compound (CAS:194869-14-2) was as follows: trifluoroacetic acid (20 mL) was slowly added dropwise to a solution of compound 11 (5 g, 14.3 mmol) in dichloromethane (60 mL) at 0 °C. The reaction mixture was gradually warmed up to room temperature and stirred for 2 h under light protection. Upon completion of the reaction, the reaction solution was concentrated by rotary evaporator and diluted with ethyl acetate (150 mL). The pH was adjusted to 7~8 by slowly adding saturated aqueous NaHCO3 solution through a dropping funnel at 0 °C. The aqueous layer was extracted with ethyl acetate (80 mL × 2). The organic phases were combined, washed with saturated aqueous NaCl (150 mL), dried over anhydrous Na2SO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 10:1) to afford 2-iodo-3-methoxyaniline (3.2 g, 90% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.07 (t, J = 8.0 Hz, 1H), 6.42-6.40 (m, 1H), 6.24-6.21 (m, 1H), 4.22 (br, 2H), 3.85 (s, 3H).13C NMR (100 MHz, CDCl3) δ 158.9, 148.4, 129.5, 107.8, 100.7, 76.0, 56.3. mass spectra (ESI, m/z) measured value 250.0 ([M + H]+).
References
[1] Synlett, 2005, # 16, p. 2469 - 2472
[2] Tetrahedron Letters, 2011, vol. 52, # 19, p. 2488 - 2491
2-Iodo-3-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| Nanjing ShengSai Chemical Co., Ltd. | 025-85205967 13951876367 | shengsaichem@163.com | China | 818 | 58 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 | |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Beijing Hechemist Technology CO.,LTD | 18511709189; | sales@hechemist.com | China | 2835 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai CR Corporation Limited | 13917420128 13062833949 | fred.wen@crcorporation.cn | China | 9776 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
