FMOC-GAMMA-ABU-OH
- CAS No.
- 116821-47-7
- Chemical Name:
- FMOC-GAMMA-ABU-OH
- Synonyms
- FMOC-GABA-OH;FMOC-GABA;FMOC-4-ABU-OH;Fmoc-Gamma-OH;Fmoc-γ-Abu-OH;FMOC-ABU(4)-OH;FMOC-GAMMA-ABU-OH;RARECHEM EM WB 0021;FMOC-NH-(CH2)3-COOH;FMOC-GAMMA-ABU-OH 1 G
- CBNumber:
- CB8165033
- Molecular Formula:
- C19H19NO4
- Molecular Weight:
- 325.36
- MDL Number:
- MFCD00144889
- MOL File:
- 116821-47-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Fmoc-GABA-OH ≥97.0% (HPLC) | 04069 | 1g | $96.3 |
| Fmoc-γ-Abu-OH Novabiochem? | 8.52043 | 5G | $184 |
| Fmoc-GABA-OH ≥97.0% (HPLC) | 04069 | 5g | $187 |
| Fmoc-γ-Abu-OH Novabiochem? | 8.52043 | 1g | $19.65 |
| Fmoc-γ-Abu-OH Novabiochem? | 8.52043 | 25g | $679 |
| More product size | |||
| Melting point | 172.0 to 176.0 °C |
|---|---|
| Boiling point | 571.9±33.0 °C(Predicted) |
| Density | 1.256±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 4.68±0.10(Predicted) |
| form | Powder |
| color | White |
| Water Solubility | Slightly soluble in water. |
| BRN | 7491485 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C19H19NO4/c21-18(22)10-5-11-20-19(23)24-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17H,5,10-12H2,(H,20,23)(H,21,22) |
| InChIKey | ACUIFAAXWDLLTR-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCCNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| CAS DataBase Reference | 116821-47-7(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2924 29 70 | |||||||||
| HazardClass | IRRITANT | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
FMOC-GAMMA-ABU-OH price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 04069 | Fmoc-GABA-OH ≥97.0% (HPLC) | 116821-47-7 | 1g | $96.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52043 | Fmoc-γ-Abu-OH Novabiochem? | 116821-47-7 | 5G | $184 | 2026-04-30 | Buy |
| Sigma-Aldrich | 04069 | Fmoc-GABA-OH ≥97.0% (HPLC) | 116821-47-7 | 5g | $187 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52043 | Fmoc-γ-Abu-OH Novabiochem? | 116821-47-7 | 1g | $19.65 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.52043 | Fmoc-γ-Abu-OH Novabiochem? | 116821-47-7 | 25g | $679 | 2025-07-31 | Buy |
FMOC-GAMMA-ABU-OH Chemical Properties,Uses,Production
Description
Fmoc-4-aminobutanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-4-aminobutanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
White powder
Uses
4-(Fmoc-amino)butyric acid is used in agrochemical, pharmaceutical and dyestuff field.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
82911-69-1
56-12-2
116821-47-7
At room temperature, γ-aminobutyric acid (2.00 g, 19.4 mmol) was dissolved in 14 mL of 10% NaHCO3 aqueous solution. Subsequently, a solution of 9-fluorenylmethyl-N-succinimidyl carbonate (4 g, 11.7 mmol) in acetonitrile (40 mL) was slowly added dropwise over a period of 2 hours. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 1 hour. After completion of the reaction, the acetonitrile was removed by distillation under reduced pressure. The aqueous phase was acidified to pH 1 with 10% HCl, at which time a white precipitate was produced. The precipitate was washed sequentially with two portions of 20 mL of water and 20 mL of ethyl acetate, and then dried under reduced pressure to give 4-(fluorenylmethoxycarbonylamino)butanoic acid (Fmoc-GABA) as a white solid in 73% (2.8 g) yield. The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6, 400 MHz), nuclear magnetic resonance carbon spectroscopy (13C NMR, DMSO-d6, 100 MHz) and mass spectrometry (ESI+).1H NMR (DMSO-d6, 400 MHz): δ 7.89 (d, 2H, J = 7.4 Hz), 7.44 (d, 2H, J = 7.2 Hz), 7.42 (t, 2H, J = 7.5 Hz), 7.35 (s, 1H), 7.33 (t, 2H, J = 7.0 Hz), 4.30 (d, 2H, J = 7 Hz), 4.21 (t, 1H, J = 6.7 Hz), 3.01 (q, 2H, J = 5.6 Hz), 2.20 (t, 2H, J = 7.3 Hz ), 1.63 (q, 2H, J = 7.1 Hz); 13C NMR (DMSO-d6, 100 MHz): δ 142.6, 139.4, 137.4, 128.9, 127.2, 124.2, 121.3, 120.0, 109.6, 77.5, 61.8, 51.1, 31.6; MS (ESI+): m/ z (intensity), 325.8 ([M + H]+, 100%).
References
[1] Chemical Biology and Drug Design, 2015, vol. 86, # 4, p. 837 - 848
[2] Patent: WO2018/144880, 2018, A1. Location in patent: Paragraph 64-65
FMOC-GAMMA-ABU-OH Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1100 | 58 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8742 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18903 | 58 |
View Lastest Price from FMOC-GAMMA-ABU-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-01 | Fmoc-γ-Abu-OH / Fmoc-4-Abu-OH
116821-47-7
|
1kgkg | 98% | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2020-01-03 | FMOC-GAMMA-ABU-OH
116821-47-7
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- Fmoc-γ-Abu-OH / Fmoc-4-Abu-OH
116821-47-7
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- FMOC-GAMMA-ABU-OH
116821-47-7
- $1.00
- 99%
- Career Henan Chemical Co
116821-47-7(FMOC-GAMMA-ABU-OH)Related Search:
1of4
