4-Nitrophenylboronic acid pinacol ester
- CAS No.
- 171364-83-3
- Chemical Name:
- 4-Nitrophenylboronic acid pinacol ester
- Synonyms
- 4,4,5,5-tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane;4-Nitrophenylboronic acid picol ester;-Nitrophenylboronic acid pinacol ester;4-NITROPHENYLBORONIC ACID PINACOL ESTER;4-Nitrobenzeneboronic acid, pinacol ester;4-Nitrophenylboronic acid, pinacol ester - [N4802];4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE;1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(4-nitrophenyl)-;4-Nitrophenylboronic acid pinacol ester ISO 9001：2015 REACH;1-Nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene
- CBNumber:
- CB8177580
- Molecular Formula:
- C12H16BNO4
- Molecular Weight:
- 249.07
- MDL Number:
- MFCD02179437
- MOL File:
- 171364-83-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Nitrophenylboronic acid pinacol ester ≥95% | 643890 | 1g | $72.8 |
| 4-Nitrophenylboronic acid pinacol ester ≥95% | 643890 | 5g | $167 |
| 4,4,5,5-Tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane >98.0%(GC) | T3710 | 1g | $23 |
| 4,4,5,5-Tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane >98.0%(GC) | T3710 | 5g | $90 |
| 4-Nitrobenzeneboronic acid, pinacol ester >97% | OR10574 | 5g | $21 |
| More product size | |||
| Melting point | 112-116 °C (lit.) |
|---|---|
| Boiling point | 357.5±25.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder or crystals |
| color | White to Orange to Green |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C12H16BNO4/c1-11(2)12(3,4)18-13(17-11)9-5-7-10(8-6-9)14(15)16/h5-8H,1-4H3 |
| InChIKey | LUWACRUAJXZANC-UHFFFAOYSA-N |
| SMILES | O1C(C)(C)C(C)(C)OB1C1=CC=C([N+]([O-])=O)C=C1 |
| CAS DataBase Reference | 171364-83-3(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Harmful/Store Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Nitrophenylboronic acid pinacol ester price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 643890 | 4-Nitrophenylboronic acid pinacol ester ≥95% | 171364-83-3 | 1g | $72.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 643890 | 4-Nitrophenylboronic acid pinacol ester ≥95% | 171364-83-3 | 5g | $167 | 2026-04-30 | Buy |
| TCI Chemical | T3710 | 4,4,5,5-Tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane >98.0%(GC) | 171364-83-3 | 1g | $23 | 2026-04-30 | Buy |
| TCI Chemical | T3710 | 4,4,5,5-Tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane >98.0%(GC) | 171364-83-3 | 5g | $90 | 2026-04-30 | Buy |
| Apolloscientific | OR10574 | 4-Nitrobenzeneboronic acid, pinacol ester >97% | 171364-83-3 | 5g | $21 | 2026-06-04 | Buy |
4-Nitrophenylboronic acid pinacol ester Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
Reactant involved in: • ;Synthesis of aryl azides 1• ;Arylation of allylic chlorides2• ;Syntehsis of RNA conjugates3• ;Alkoxycarbonylation4• ;Synthesis of mTOR and PI3K inhibitors as antitumor agents5• ;Electrooxidative synthesis of biaryls6
Uses
suzuki reaction
Uses
4-Nitrobenzeneboronic acid pinacol ester is a reactant involved in synthesis of aryl azides, arylation of allylic chlorides, synthesis of RNA conjugates, alkoxycarbonylation, synthesis of mTOR and PI3K inhibitors as antitumor agents, electro oxidative synthesis of biaryls.
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 7508, 1995 DOI: 10.1021/jo00128a024
Synthesis
100-01-6
73183-34-3
171364-83-3
GENERAL PROCEDURE: To a solution of 4-nitroaniline (0.5 mmol, 1.0 eq.) in methanol (1.0 mL) was added hydrochloric acid (0.5 mL, 1.5 mmol, 3.0 eq.) followed by water (0.5 mL). The mixture was stirred for 2 minutes and then sodium nitrite solution (0.25 mL) was added. Sodium nitrite solution was prepared by dissolving 35 mg of sodium nitrite in water (0.25 mL). The reaction mixture was stirred at 0-5 °C for 30 min, followed by the addition of a methanol (1.0 mL) solution of pinacol ester of bisboronic acid (2,381 mg, 1.5 mmol, 3.0 equiv). Stirring was continued for 60 minutes. Upon completion of the reaction, water (10 mL) was added to the mixture, which was then extracted with dichloromethane (50 mL, 3 times). The organic layers were combined and washed with saturated sodium bicarbonate solution followed by drying with anhydrous sodium sulfate. After drying, the solvent was evaporated and the crude product was purified by fast chromatography.
References
[1] Synlett, 2014, vol. 25, # 11, p. 1577 - 1584
[2] Angewandte Chemie - International Edition, 2010, vol. 49, # 10, p. 1846 - 1849
[3] Tetrahedron Letters, 2016, vol. 57, # 14, p. 1551 - 1554
[4] Synlett, 2012, vol. 23, # 9, p. 1394 - 1396
4-Nitrophenylboronic acid pinacol ester Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1082 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5597 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9984 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9040 | 58 |
View Lastest Price from 4-Nitrophenylboronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-06 | 4-Nitrophenylboronic acid pinacol ester
171364-83-3
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2023-11-27 | 4-Nitrophenylboronic acid pinacol ester
171364-83-3
|
1kg | 99.9% | 30000 Kg | Hebei Xinsheng New Material Technology Co., LTD. | ||
 |
2023-10-28 | 4-Nitrophenylboronic acid pinacol ester
171364-83-3
|
$25.00-35.00 | 1kg | 99% | 20 Ton | Hebei Xinsheng New Material Technology Co., LTD. |
-
- 4-Nitrophenylboronic acid pinacol ester
171364-83-3
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Nitrophenylboronic acid pinacol ester
171364-83-3
- 99.9%
- Hebei Xinsheng New Material Technology Co., LTD.
-
- 4-Nitrophenylboronic acid pinacol ester
171364-83-3
- $25.00-35.00
- 99%
- Hebei Xinsheng New Material Technology Co., LTD.
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