Methyl 3,5-dihydroxybenzoate
- CAS No.
- 2150-44-9
- Chemical Name:
- Methyl 3,5-dihydroxybenzoate
- Synonyms
- AKOS 227-38;Myvaplex 600;RARECHEM AL BF 0252;METHYL-A-RESORCYLATE;3,5-dihydroxybenzoate;Methyl 3,5-dihydroxyben;Methyl alpha-resorcylate;α-Resorcylic acid methyl;METHYL 3,5-DIHYDROXYBENZOATE;3,5-Dihydroxy Methyl Benzoate
- CBNumber:
- CB8192187
- Molecular Formula:
- C8H8O4
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD00002289
- MOL File:
- 2150-44-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 167-170 °C (lit.) |
|---|---|
| Boiling point | 257.07°C (rough estimate) |
| Density | 1.3037 (rough estimate) |
| refractive index | 1.5090 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetone (Slightly), Methanol (Slightly) |
| form | Fine Crystalline Powder |
| pka | 8.63±0.10(Predicted) |
| color | Slightly yellow to beige |
| Water Solubility | Slightly soluble in water. |
| BRN | 2091651 |
| InChI | InChI=1S/C8H8O4/c1-12-8(11)5-2-6(9)4-7(10)3-5/h2-4,9-10H,1H3 |
| InChIKey | RNVFYQUEEMZKLR-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC(O)=CC(O)=C1 |
| CAS DataBase Reference | 2150-44-9(CAS DataBase Reference) |
| FDA UNII | 41U1BRD8AX |
| EPA Substance Registry System | Benzoic acid, 3,5-dihydroxy-, methyl ester (2150-44-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29182900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 3,5-dihydroxybenzoate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 159603 | Methyl 3,5-dihydroxybenzoate 97% | 2150-44-9 | 25g | $63.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 159603 | Methyl 3,5-dihydroxybenzoate 97% | 2150-44-9 | 100g | $235 | 2026-04-30 | Buy |
| TCI Chemical | D2215 | Methyl 3,5-Dihydroxybenzoate >98.0%(GC) | 2150-44-9 | 25g | $56 | 2026-04-30 | Buy |
| TCI Chemical | D2215 | Methyl 3,5-Dihydroxybenzoate >98.0%(GC) | 2150-44-9 | 250g | $320 | 2026-04-30 | Buy |
| TRC | TRC-D451715-2G | 3,5-Dihydroxybenzoic Acid Methyl Ester | 2150-44-9 | 2g | $59 | 2026-06-03 | Buy |
Methyl 3,5-dihydroxybenzoate Chemical Properties,Uses,Production
Chemical Properties
slightly yellow to beige fine crystalline powder
Uses
The methyl ester of 3,5-Dihydroxybenzoic Acid (D451700) with potential antifeedant activity for pine weevil, Hylobius abietis.
Uses
Methyl 3,5-dihydroxybenzoate was used in the synthesis of cored dendrimers. It was also used in the preparation of bis(5-carbomethoxy-1,3-phenylene)-32-crown-10, a semi-rigid 32-membered ring diester crown ether.
General Description
Ribonucleotide reductase inhibiton and antiumor activity of methyl 3,5-dihydroxybenzoate has been studied.
Synthesis
67-56-1
99-10-5
2150-44-9
Methyl 3,5-dihydroxybenzoate was synthesized from methanol and 3,5-dihydroxybenzoic acid using the method described by Brouwer et al. The method was adapted for the metathesis synthesis of amino acid-based dendritic polymers, aiming at obtaining dendritic macromolecules with alkyne groups on the surface for 1,3-dipolar cycloaddition ("click") reactions with amino acid/peptide-derived azides. This was done as follows: first, 3,5-dihydroxymethylbenzoate (21.4 g, 130 mmol) was dissolved in anhydrous DMF (250 mL), followed by the addition of anhydrous K2CO3 (45 g, 330 mmol, 2.5 eq.). A toluene solution of propargyl bromide (35 mL, 314 mmol, 2.5 eq.) was added slowly and dropwise to this suspension. The reaction mixture was stirred continuously for 48 hours at room temperature. Upon completion of the reaction, DMF was removed by evaporation and the residue was redissolved in EtOAc (400 mL). The organic phase was washed sequentially with H2O (3 × 100 mL), KHSO4 (3 × 100 mL) and brine (3 × 100 mL), after which it was dried with Na2SO4 and evaporated under vacuum. The residue was recrystallized by EtOAc/hexane to afford the target product 1 as off-white crystals in 81% yield (25.2 g). The product was characterized by thin layer chromatography (TLC) and nuclear magnetic resonance (NMR): Rf (EtOAc/hexane 4:1 v/v): 0.76; Rf (DMC/MeOH 98:2 v/v): 0.87; Rf (CHCl3/MeOH/AcOH 95:20:3 v/v): 0.83; 1H-NMR (CDCl3) δ 2.55 (t, J=2.47Hz, 2H), 3.91 (s, 3H), 4.72 (d, J=2.47Hz, 4H), 6.81 (t, J=2.20Hz, 1H), 7.29 (d, J=2.20Hz, 2H); 13C-NMR (CDCl3) δ 52.4, 56.0, 76.0, 77.9, 107.5, 108.8, 132.0, 157.8, 158.4; elemental analysis results: C14H12O4, calculated value C 68.83, H 4.95, measured value C 68.76, H 4.95.
References
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2825 - 2829
[2] Chemistry Letters, 1999, # 11, p. 1193 - 1194
[3] Chemical Communications, 2005, # 36, p. 4581 - 4583
[4] Patent: EP1733742, 2006, A1. Location in patent: Page/Page column 5-6; 12
[5] Journal of the American Chemical Society, 2007, vol. 129, # 10, p. 2774 - 2776
Methyl 3,5-dihydroxybenzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Rhawn Reagent | 400-400-1332688 18019345275 | huyue@rhawn.cn | China | 14942 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from Methyl 3,5-dihydroxybenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | Methyl 3,5-dihydroxybenzoate
2150-44-9
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2023-09-07 | Methyl 3,5-dihydroxybenzoate
2150-44-9
|
$30.00 | 1KG | 99% | 1000t/year | Anhui Ruihan Technology Co., Ltd | |
 |
2023-02-18 | Methyl 3,5-dihydroxybenzoate
2150-44-9
|
1kg | 98% | Aromsyn Co., Ltd. |
-
- Methyl 3,5-dihydroxybenzoate
2150-44-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Methyl 3,5-dihydroxybenzoate
2150-44-9
- $30.00
- 99%
- Anhui Ruihan Technology Co., Ltd
-
- Methyl 3,5-dihydroxybenzoate
2150-44-9
- 98%
- Aromsyn Co., Ltd.
