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(R)-(-)-Epichlorohydrin

(R)-(-)-Epichlorohydrin structure

CAS No.: 51594-55-9

Chemical Name:: (R)-(-)-Epichlorohydrin

Synonyms: 2-(Chloromethyl)oxirane;(R)-EPICHLOROHYDRIN;(2R)-2-(CHLOROMETHYL)OXIRANE;EPICHOLOROHYDRIN;(R)-(-)-Epichlorohyd;orohydrin;(R)-(−(R)-(-)-EpichL;EPICHLOROHYDINE;L-Epichlorohydrin

CBNumber:: CB9292835

Molecular Formula:: C3H5ClO

Molecular Weight:: 92.52

MDL Number:: MFCD00077759

MOL File:: 51594-55-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-29 13:42:05

Product description	Number	Pack Size	Price
(R)-(?)-Epichlorohydrin 99%	540072	5g	$30.9
(R)-(?)-Epichlorohydrin 99%	540072	25g	$70.4
(R)-Epichlorohydrin >98.0%(GC)	E0581	5g	$17
(R)-Epichlorohydrin >98.0%(GC)	E0581	25g	$45
(R)-(-)-Epichlorohydrin 99+% ≥99%(Assay)	241512	5g	$170
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(R)-(-)-Epichlorohydrin Properties

Melting point	-48°C
alpha	34 º (589nm, c=1, MeOH)
Boiling point	114 °C(lit.)
Density	1.180 g/mL at 20 °C(lit.)
vapor density	3.29 (vs air)
vapor pressure	10 mm Hg ( 16.6 °C)
refractive index	n20/D 1.438(lit.)
Flash point	33 °C
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Liquid
color	Clear colorless to very pale yellow
explosive limit	21%
optical activity	[α]20/D 34°, c = 1 in methanol
Water Solubility	insoluble
Merck	14,3532
BRN	1420785
InChI	1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1
InChIKey	BRLQWZUYTZBJKN-VKHMYHEASA-N
SMILES	ClC[C@H]1CO1
CAS DataBase Reference	51594-55-9(CAS DataBase Reference)
FDA UNII	VEC01H609I
NIST Chemistry Reference	Oxirane, (chloromethyl)-, (R)-(51594-55-9)
UNSPSC Code	12352103
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS06,GHS08

Signal word

Danger

Hazard statements

H226-H301+H311+H331-H314-H317-H350

Precautionary statements

P202-P210-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

45-10-23/24/25-34-43

Safety Statements

53-45

RIDADR

UN 2023 6.1/PG 2

WGK Germany

RTECS

RR0427000

Autoignition Temperature

772 °F

TSCA

Yes

HazardClass

6.1

PackingGroup

HS Code

29103000

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Carc. 1B
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B
Skin Sens. 1

REACH Registrations

Active

Limited Quantities

100ml (liquid) or 0.5 Kg (solid)

Excepted Quantities

Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
3		0

(R)-(-)-Epichlorohydrin price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	540072	(R)-(?)-Epichlorohydrin 99%	51594-55-9	5g	$30.9	2026-04-30	Buy
Sigma-Aldrich	540072	(R)-(?)-Epichlorohydrin 99%	51594-55-9	25g	$70.4	2026-04-30	Buy
TCI Chemical	E0581	(R)-Epichlorohydrin >98.0%(GC)	51594-55-9	5g	$17	2026-04-30	Buy
TCI Chemical	E0581	(R)-Epichlorohydrin >98.0%(GC)	51594-55-9	25g	$45	2026-04-30	Buy
Usbiological	241512	(R)-(-)-Epichlorohydrin 99+% ≥99%(Assay)	51594-55-9	5g	$170	2026-06-03	Buy

Product number	Packaging	Price	Buy
540072	5g	$30.9	Buy
540072	25g	$70.4	Buy
E0581	5g	$17	Buy
E0581	25g	$45	Buy
241512	5g	$170	Buy

(R)-(-)-Epichlorohydrin Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

((R)-Epichlorohydrin) R-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.

Uses

Building block for the synthesis of a key intermediate in the synthesis of stable PGI₂ analogue UT-15.

Definition

ChEBI: (R)-epichlorohydrin is an epichlorohydrin. It is functionally related to a (S)-1,2-epoxypropane. It is an enantiomer of a (S)-epichlorohydrin.

Pharmaceutical Applications

Chiral epichlorohydrin (ECH) represents a key building block owing to its low molecular weight, simple structure, and high reactivity, serving as a versatile chiral synthon for many pharmaceutical agents, serves as a critical intermediate for the production of l-carnitine, pheromones, and various β-blockers, where its enantiomeric purity directly dictates the efficacy and safety of the final therapeutic products^[1].

Synthesis

The enzymatic production of (R)-(-)-Epichlorohydrin is predominantly achieved through the kinetic resolution of racemic mixtures or the direct dehalogenative cyclization of prochiral substrates, utilizing epoxide hydrolases or haloalcohol dehalogenases as catalyst.

References

[1] Wu, K., Lai, Z., Xu, Y., Wu, T., & Mu, X. (2026). Overcoming the concentration-enantioselectivity trade-off in haloalcohol dehalogenase for high-titer (R)-epichlorohydrin production. International Journal of Biological Macromolecules, 358, Article 151790. https://doi.org/10.1016/j.ijbiomac.2026.151790

(R)-(-)-Epichlorohydrin Preparation Products And Raw materials

Raw materials

(S)-(+)-3-Chloro-1,2-propanediol (R)-(-)-3-Chloro-1,2-propanediol Epichlorohydrin

Preparation Products

(S)-4-Chloro-3-hydroxybutyronitrile (S)-(+)-Epichlorohydrin (2S)-1,4-Dioxan-2-yl-methanol (S)-2-Oxiranylanisole DIGLYCIDYL ETHER

(R)-4-Chloro-3-hydroxybutyronitrile Morpholine, 4-[(2R)-oxiranylmethyl]- (9CI) L-carnitine

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(R)-(-)-Epichlorohydrin Suppliers

Global( 457)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177	faithe@yan-xi.com	China	5838	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5218	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-17732866630	mina@chuanghaibio.com	China	18114	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	13343047651	admin@zlchemi.com	China	3689	58
Nantong Provichem Biotech Co., Ltd.	+8617505220108	sales@provichem.cn	China	96	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8618017249410	jack.li@time-chemicals.com	China	1796	55

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Nantong Provichem Biotech Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55

View Lastest Price from (R)-(-)-Epichlorohydrin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-06	(R)-(-)-Epichlorohydrin 51594-55-9	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-07-24	(R)-Epichlorohydrin 51594-55-9	$10.00	1kg	≥ 99.5	20 tons	Nantong Provichem Biotech Co., Ltd.
2026-06-30	(R)-(-)-Epichlorohydrin 51594-55-9		1KG	99.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

(R)-(-)-Epichlorohydrin
51594-55-9
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

(R)-Epichlorohydrin
51594-55-9
$10.00
≥ 99.5
Nantong Provichem Biotech Co., Ltd.

(R)-(-)-Epichlorohydrin
51594-55-9
99.0%
Shaanxi Dideu New Materials Co. Ltd

(R)-(-)-Epichlorohydrin Spectrum

(R)-(-)-Epichlorohydrin(51594-55-9)¹HNMR (R)-(-)-Epichlorohydrin(51594-55-9)FT-IR (R)-(-)-Epichlorohydrin(51594-55-9)Raman

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(R)-3-Chloro-1,2-epoxypropane 2-(Chlorometyl)oxirane R(-)-2-(CHLOROMETHYL)OXIRANE (R) Epichlorohydin or (R)1-chloro-2,3-epoxypropane (R)-(-)-Epichlorohydrin,99% 2-(Chloromethyl)oxirane (R)-()-Epichlorohydrin,(R)-()-2-(Chloromethyl)oxirane (2R)-(-)-3-Chloro-1,2-propenoxide (2R)-(-)-2-(Chloromethyl)oxirane, (R)-(-)-Epichlorohydrin (R)-(-)-Epichlorohydrin, 99% 1GR (2R)-(ChloroMethyl)oxirane (R)-1-Chloro-2,3-epoxypropane (R)-Chloromethyloxirane (R)-3-Chloropropylene Oxide (2R)-(-)-2-(Chloromethyl)oxirane, (R)-(-)-Epichlorohydrin, (R)-(-)-Glycidyl chloride Oxirane,2-(chloroMethyl)-, (2R)- (R)-(-)-Epichlorohydrin (R)-3-Chloropropylene Oxide (R)-(&minus (R)-(-)-EpichL orohydrin )-7-Desmethyl-8-nitro Blebbistatin (2R)-(-)-3-Chloro-1,2-propenoxide 99% (R)-(+)-2-(Chloromethyl)oxirane / R-Epichlorohydrin Rivaroxaban Impurity 122 (R)-(-)-1-CHLORO-2,3-EPOXYPROPANE (R)-1-CHLORO-2,3-EPOXYPROPANE (R)-(-)-CHLOROMETHYLOXIRANE (R)-CHLOROMETHYLOXIRANE (R)-(-)-EPICHLOROHYDRIN OXIRANE, (CHLOROMETHYL)-, (2R)- EPICHLOROHYDINE EPICHLOROHYDRIN 99.5% R-(-)-EpichloRohydRine (R)-(-)-EPICHLOROHYDRIN 99% (R)-(-)-alpha-Epichlorohydrine (R)-(-)-Epichlorohydrin, 98+% L-Epichlorohydrin (R)-Epichlorohydrin> (R)-(-)-Epichlorohydrin ISO 9001：2015 REACH (-)-Epichlorohydrin (R)--Epichlorohydnin (2R)-2-(CHLOROMETHYL)OXIRANE (R)-(-)-Epichlorohyd (R)-EPICHLOROHYDRIN EPICHOLOROHYDRIN 51594-55-9 1594-55-9 51597-55-9 C3H5CIO CH2ClC2H3O C3H5ClO Asymmetric Synthesis Epoxides Organic Building Blocks Simple 3-Membered Ring Compounds Glycidyl Compounds, etc. (Chiral) Chiral Building Blocks Oxiranes Industrial/Fine Chemicals