Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
![Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Structure](CAS/GIF/317318-97-1.gif)
- CAS No.
- 317318-97-1
- Chemical Name:
- Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
- Synonyms
- ChloroMethylthiazole;5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole;4-[5-(Chloromethyl)-4-methyl-1,3-thiazol-2-yl]benzotrifluoride;5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-...;Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-;5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
- CBNumber:
- CB82077394
- Molecular Formula:
- C12H9ClF3NS
- Molecular Weight:
- 291.72
- MDL Number:
- MFCD03791173
- MOL File:
- 317318-97-1.mol
- MSDS File:
- SDS
| Melting point | 60-62° |
|---|---|
| Boiling point | 363.5±52.0 °C(Predicted) |
| Density | 1.357±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform, Methanol |
| form | Solid |
| pka | 1.62±0.10(Predicted) |
| color | Yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H290-H302-H318-H341b-H410 |
| Precautionary statements | P201-P202-P264b-P270-P281-P305+P351+P338-P310-P330-P390-P406b-P501c |
| HazardClass | IRRITANT |
| HS Code | 2934100090 |
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-C379930-5MG | 5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole | 317318-97-1 | 5mg | $72 | 2026-06-03 | Buy |
| TRC | TRC-C379930-20MG | 5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole | 317318-97-1 | 20mg | $193 | 2026-06-03 | Buy |
| TRC | TRC-C379930-10MG | 5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole | 317318-97-1 | 10mg | $123 | 2026-06-03 | Buy |
| Usbiological | 006662 | 5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole | 317318-97-1 | 20mg | $446 | 2026-06-03 | Buy |
| Apolloscientific | PC10200 | 5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole | 317318-97-1 | 1g | $21 | 2026-06-04 | Buy |
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Chemical Properties, Uses, Production
Chemical Properties
Yellow Solid
Uses
Intermediate in the production of GW 501516 and its derivatives
Synthesis
639784-17-1
121-44-8
![Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-](/CAS/GIF/317318-97-1.gif)
317318-97-1
To a stirred solution of Intermediate 1 (8.2 g, 30 mmol) and triethylamine (6.07 g, 8.36 mL, 60 mmol) in anhydrous dichloromethane (120 mL) at 0 °C was slowly added methanesulfonyl chloride (5.49 g, 3.71 mL, 48 mmol). After 2 hours of reaction at 0°C, additional triethylamine (6 mmol) and methanesulfonyl chloride (4.8 mmol) were added. After 2 hours of reaction, thin layer chromatography (TLC, unfolding agent: hexane/ethyl acetate, 1:1) showed complete reaction. The reaction mixture was diluted with dichloromethane (120 mL) and washed sequentially with saturated sodium bicarbonate solution (2 x 240 mL) and water (2 x 240 mL), and the organic phase was dried, filtered, and concentrated to afford 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (8.0 g, 27 mmol, 90% yield) as a yellow solid.
References
[1] Patent: WO2004/785, 2003, A2. Location in patent: Page 43
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Everchem Co., Ltd | 86-29-81325371 | info@everchem.cn | China | 82 | 62 |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| ShangHai Onsyn-Chemical Technology Co., Ltd. | 13917628136 15900795984 | 572350448@qq.com | China | 259 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
View Latest Price from Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 5-(chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazole
317318-97-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
![Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- pictures](https://img.chemicalbook.com/ProductImageEN/2019-7/Small/04f4c448-3c90-44fd-9be5-c97c961de704.png) |
2019-07-06 | Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
317318-97-1
|
1KG | 98% | 150KG | Career Henan Chemical Co |
-
- 5-(chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazole
317318-97-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
317318-97-1
- $0.00
- 98%
- Career Henan Chemical Co
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