3-Methyl-3-pyrazolin-5-one
- CAS No.
- 4344-87-0
- Chemical Name:
- 3-Methyl-3-pyrazolin-5-one
- Synonyms
- 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-;AKOS B028792;3 METHYLPYRAZOLONE;5-Methyl-1H-pyrazole-3-ol;3-METHYL-3-PARAZOLIN-5-ONE;3-METHYL-3-PYRAZOLIN-5-ONE;3-Hydroxy-5-methylpyrazole;3-Methyl-3-pyrazoline-5-one;5-METHYL-3-HYDROXY PYRAZOLE;3-methyl-5-pyridineazoleone
- CBNumber:
- CB8217187
- Molecular Formula:
- C4H6N2O
- Molecular Weight:
- 98.1
- MDL Number:
- MFCD00010705
- MOL File:
- 4344-87-0.mol
- MSDS File:
- SDS
| Melting point | 223-225 °C (lit.) |
|---|---|
| Density | 1.107±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | 1 M NH4OH: soluble25mg/mL, clear, colorless (in methanol) |
| form | solid |
| pka | 9.04±0.70(Predicted) |
| color | Off White |
| InChI | 1S/C4H6N2O/c1-3-2-4(7)6-5-3/h2H,1H3,(H2,5,6,7) |
| InChIKey | WGVHNCAJPFIFCR-UHFFFAOYSA-N |
| SMILES | CC1=CC(=O)NN1 |
| CAS DataBase Reference | 4344-87-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39-36 |
| WGK Germany | 3 |
| HS Code | 2933119000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
3-Methyl-3-pyrazolin-5-one price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 303062 | 3-Methyl-3-pyrazolin-5-one 98% | 4344-87-0 | 25g | $50.1 | 2023-06-20 | Buy |
| SynQuest Laboratories | 4H01-1-32 | 3-Methyl-5-hydroxypyrazole 95% | 4344-87-0 | 5g | $250 | 2026-05-22 | Buy |
| SynQuest Laboratories | 4H01-1-32 | 3-Methyl-5-hydroxypyrazole 95% | 4344-87-0 | 25g | $750 | 2026-05-22 | Buy |
| Synthonix | M12010 | 1,2-Dihydro-5-methyl-3H-pyrazol-3-one 97.0% | 4344-87-0 | 10g | $16 | 2026-05-06 | Buy |
| Synthonix | M12010 | 1,2-Dihydro-5-methyl-3H-pyrazol-3-one 97.0% | 4344-87-0 | 25g | $22 | 2026-05-06 | Buy |
3-Methyl-3-pyrazolin-5-one Chemical Properties,Uses,Production
Chemical Properties
Light yellow crystalline powder
Uses
3-Methyl-3-pyrazolin-5-one was used in the preparation of substituted 4-alkyl(cycloalkyl)-2-amino-3-cyano-4H-pyrans.
General Description
3-Methyl-3-pyrazolin-5-one is an intermediate in the synthesis of heterocyclic compounds. Crystal structure of 3-methyl-3-pyrazolin-5-one was studied.
Synthesis
141-97-9
4344-87-0
GENERAL METHODS: Phenylhydrazine (1 mmol), ethyl acetoacetate (1 mmol) and cobalt doped ZnS nanoparticles (5 mol%) were mixed in a Borosil beaker. The reaction mixture was homogeneously mixed using a glass rod and placed in an infrared reactor (360 W) for irradiation. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature. Subsequently, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was purified by recrystallization from hot ethanol. Nanoparticles were recovered by sonication of the aqueous phase and could be reused four times in the same reaction.
References
[1] Journal of Molecular Catalysis A: Chemical, 2013, vol. 373, p. 61 - 71
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 4, p. 507 - 516
[3] Patent: WO2015/200650, 2015, A1. Location in patent: Paragraph 0532-0534
[4] Chemische Berichte, 1896, vol. 29, p. 257
[5] Journal fuer Praktische Chemie (Leipzig), 1889, vol. <2> 39, p. 52
3-Methyl-3-pyrazolin-5-one Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methyl-3-pyrazolin-5-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 |
View Lastest Price from 3-Methyl-3-pyrazolin-5-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 3-Methyl-3-pyrazolin-5-one
4344-87-0
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
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- 3-Methyl-3-pyrazolin-5-one
4344-87-0
- $1.00
- 99%
- Career Henan Chemical Co
