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2,3-Di-O-para-toluoyl-D-tartaric acid

2,3-Di-O-para-toluoyl-D-tartaric acid structure

CAS No.: 32634-68-7

Chemical Name:: 2,3-Di-O-para-toluoyl-D-tartaric acid

Synonyms: D-DTTA;DI-P-TOLUOYL-D-TARTARIC ACID;D-PTTA;(+)-Di-p-toluoyl-D-tartaric Acid;(+)-DTTA;Di-p-Toluoyl-D-tartaric;RivastigMine Related CoMpound A;O,O'-DI-P-TOLUOYL-D-TARTARIC ACID;(+)-O,O'-DI-P-TOLUOYL-D-TARTARIC ACID;2,3-Di-O-para-toluoy

CBNumber:: CB8225287

Molecular Formula:: C20H18O8

Molecular Weight:: 386.35

MDL Number:: MFCD00008552

MOL File:: 32634-68-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:08:19

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2,3-Di-O-para-toluoyl-D-tartaric acid Properties

Melting point	169-171 °C(lit.)
alpha	136 º (c=1, EtOH)
Boiling point	432.57°C (rough estimate)
Density	1.3084 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	139 ° (C=1, EtOH)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Ethanol (Sparingly), Methanol (Slightly)
form	Solid
pka	1.46±0.25(Predicted)
color	White to Off-White
optical activity	[α]19/D +138°, c = 1 in ethanol
Water Solubility	112.55mg/L at 25℃
BRN	3225584
InChI	1S/C20H18O8/c1-11-3-7-13(8-4-11)19(25)27-15(17(21)22)16(18(23)24)28-20(26)14-9-5-12(2)6-10-14/h3-10,15-16H,1-2H3,(H,21,22)(H,23,24)/t15-,16-/m0/s1
InChIKey	CMIBUZBMZCBCAT-HOTGVXAUSA-N
SMILES	Cc1ccc(cc1)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(C)cc2)C(O)=O)C(O)=O
LogP	2.97 at 25℃
CAS DataBase Reference	32634-68-7(CAS DataBase Reference)
FDA UNII	4480MA5QIP
NIST Chemistry Reference	(+)-Di-o-4-toluoyl-d-tartaric acid(32634-68-7)
EPA Substance Registry System	Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)- (32634-68-7)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-36/37-26

WGK Germany

3-10

TSCA

TSCA listed

HS Code

29181300

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

REACH Registrations

Active

NFPA 704

	0
0		0

2,3-Di-O-para-toluoyl-D-tartaric acid price More Price(73)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	302813	(+)-O,O′-Di-p-toluoyl-D-tartaric acid made from synthetic tartaric acid, 97%	32634-68-7	25g	$180	2026-04-30	Buy
Sigma-Aldrich	1604869	Rivastigmine Related Compound A United States Pharmacopeia (USP) Reference Standard	32634-68-7	15mg	$1290	2026-04-30	Buy
TCI Chemical	D1417	(+)-Di-p-toluoyl-D-tartaric Acid >98.0%(HPLC)(T)	32634-68-7	25g	$34	2026-04-30	Buy
TCI Chemical	D1417	(+)-Di-p-toluoyl-D-tartaric Acid >98.0%(HPLC)(T)	32634-68-7	250g	$141	2026-04-30	Buy
TRC	TRC-D494380-5G	(+)-O,O’-Di-p-toluoyl-D-tartaric Acid	32634-68-7	5g	$72	2026-06-03	Buy

Product number	Packaging	Price	Buy
302813	25g	$180	Buy
1604869	15mg	$1290	Buy
D1417	25g	$34	Buy
D1417	250g	$141	Buy
TRC-D494380-5G	5g	$72	Buy

2,3-Di-O-para-toluoyl-D-tartaric acid Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

blood volume expander

Uses

Inhibitor of enzyme. Rivastigmine USP Related Compound A.

Flammability and Explosibility

Not classified

Synthesis

72842-25-2

32634-68-7

General procedure for the synthesis of D-(+)-di-p-toluoyltartaric acid from L-(-)-p-toluoyltartaric anhydride: 150 g of D-tartaric acid and 200 mL of toluene were added to a 1000 mL three-necked flask, and 1.5 g of copper sulfate was added as a catalyst under stirring conditions. 330 g of methylbenzoyl chloride was slowly added dropwise for a controlled period of 3 hours. After the dropwise addition, the reaction was continued for 6 hours. Upon completion of the reaction, the mixture was transferred to a centrifuge for separation. Next, 495.4 g of DP-methyldibenzoyltartaric anhydride, appropriate amount of water and toluene were added to a 2000 mL three-necked flask, heated to reflux and kept for 5 hours. At the end of the reaction, it was cooled to room temperature and 374.4 g of DP-methyldibenzoyltartaric acid was isolated. The product was used for TEM test and its structure is shown in Figure 1. The purity of the finished product D-p-methyldibenzoyltartaric acid was determined to be 99.61% with an overall yield of 96.6%.

References

[1] Patent: CN104447338, 2016, B. Location in patent: Paragraph 0034-0036

2,3-Di-O-para-toluoyl-D-tartaric acid Preparation Products And Raw materials

Raw materials

Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with (2R)-2-(cyclopropylamino)cyclohexanol (1:1) (9CI) Di-(4-toluoyl)-L-tartaric anhydride Toluene Water

Preparation Products

CARUMONAM Di-(4-toluoyl)-L-tartaric anhydride Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with methyl (4S)-8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetate (1:1)

2,3-Di-O-para-toluoyl-D-tartaric acid Suppliers

Global Suppliers ( 581)

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Likai Chiral Tech LTD.	028-85247892	suriya@lkchiralchina.com	China	45	58
Changzhou Success Chemical Co., Ltd.	18961148122; 18961148122	278954761@qq.com	China	34	58
Chengdu Zhongde Jihua Pharmaceutical Technology Co., Ltd	15928014948; 15928014948	3438599507@qq.com	China	97	58
Dalian Tianchi Jiulong Pharmaceutical Technology Co., Ltd	0411-84176838 13942036801	info@tianchiorg.com	China	52	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Chengdu Likai Chiral Tech LTD.	58
Changzhou Success Chemical Co., Ltd.	58
Chengdu Zhongde Jihua Pharmaceutical Technology Co., Ltd	58
Dalian Tianchi Jiulong Pharmaceutical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
future industrial shanghai co., ltd	65
Alfa Aesar	84

View Latest Price from 2,3-Di-O-para-toluoyl-D-tartaric acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	(+)-Di-p-toluoyl-D-tartaric acid 32634-68-7		1KG	99%min	10000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	2,3-Di-O-para-toluoyl-D-tartaric acid 32634-68-7	$2.00-10.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	2,3-Di-O-para-toluoyl-D-tartaric acid 32634-68-7		1kg	98%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

(+)-Di-p-toluoyl-D-tartaric acid
32634-68-7
$0.00
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

2,3-Di-O-para-toluoyl-D-tartaric acid
32634-68-7
$2.00-10.00
99%
Henan Fengda Chemical Co., Ltd

2,3-Di-O-para-toluoyl-D-tartaric acid
32634-68-7
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2,3-Di-O-para-toluoyl-D-tartaric acid Spectrum

2,3-Di-O-para-toluoyl-D-tartaric acid(32634-68-7)MS 2,3-Di-O-para-toluoyl-D-tartaric acid(32634-68-7)¹HNMR 2,3-Di-O-para-toluoyl-D-tartaric acid(32634-68-7)¹³CNMR 2,3-Di-O-para-toluoyl-D-tartaric acid(32634-68-7)IR1 2,3-Di-O-para-toluoyl-D-tartaric acid(32634-68-7)IR2 2,3-Di-O-para-toluoyl-D-tartaric acid(32634-68-7)Raman

32634-68-7 (2,3-Di-O-para-toluoyl-D-tartaric acid) Related Search:

(-)-Di-p-toluoyl-L-tartaric acid Di-p-toluoyl-D-tartaric acid monohydrate DL-Malic acid (+)-Dibenzoyl-D-tartaric acid monohydrate Di-p-anisoyl-L-tartaric acid

(-)-Dibenzoyl-L-tartaric acid monohydrate Dibenzoyl-L-tartaric acid (+)-Dibenzoyl-D-tartaric acid Dibenzoyltartaric acid tert-Butanesulfinamide

D-(-)-Tartaric Acid 2,3-Di-O-para-toluoyl-D-tartaric acid 4-[(1S)-(4-Dimethylamino)-1-(4-fluotophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid (+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT R-VENLAFAXINE-DI-P-TOLUOYL-D-TARTRATE SALT

1of3

RivastigMine USP RC A RivastigMine Related CoMpound A D- twoMethylbenzoyltartaric acid (+)-2,3-Di-p-toluoyl-D-tartaric acid (+)-Di-p-toluoyl-D-tartaric acid D - 2 Methyl benzoyl tartaric acid (+)-Di-1,4-toluoyl-D-tartaric acid [S(R*,R*)]-2,3-bis[(4-methylbenzoyl)oxy]succinic acid (+)- Ditoluoyltartaric acid (2S,3S)-(+)-di-O-(p-toluoyl)-tartaric acid Di-p-toluoyl-D-tartaric Acid,99%e.e. (2S,3S)-(+)-Di-O-4-toluoyl-D-tartaric acid for synthesis (-)-di-p-Toluyl-L-tartaric acid DI-(4-METHYL)BENZOYL-D-TARTARIC ACID D-(+)-TARTARIC ACID-O,O'-DI-P-TOLUOYL ESTER D-(+)-TARTARIC ACID DI-4-TOLUOYL ESTER D-PTTA (+)-DI-P-TOLUOYL-D-TRATARIC ACID DI-O-4-TOLUOYL-D-TARTARIC ACID (+)-DI-O,O'-P-TOLUYL-D-TARTARIC ACID [s(r*,r*)]-2,3-bis[(4-methylbenzoyl)oxy]succinic acid O,O'-DI-TOLUOYL-D-(+)-TARTARIC ACID Di-p-Toluoyl-D-Tartaric Acid Anhydrate Di-4-Toluoyl-D-tartaric acid DI-P-TOLUOYL-D-TARTARIC ACID, 97%, MADE FROM UNNATURAL TARTARIC ACID DI-P-Toluoyl-D-Tartaric Acid Anhydrous Di-Para-Toluoyl-D-TartaricAcid Di-Para-Toluoyl-L-TartaricAcid,Anhydrous (+)-DI-P-TOLUOYL-D-TARTARIC ACID D-(+)-DTTA 99% DI-P-TOLUOYL-D-TARTARIC ACID\ S-(-)-TERT-BUTANESULFINAMIDE (+)-DI-O,O''-P-TOLUYL-D-WEINSURE (+)-Di-p-toluyl-D-tartaric acid toluoyl-tartaric acid DI-P-TOTUOYL-D-TARTARIC ACID 3-hydroxy-2-[(2-methylphenyl)-oxomethoxy]-2-[(2-methylphenyl)-oxomethyl]butanedioic acid (-)-Nicotine (+)-O,O&rsquo (+)-Di-1,4-toluoyl-D-tartaric acid(DDTTA) (S,S)-O,O'-Di-p-toluoyltartaric acid p-Toluic acid, diester with D-tartaric acid (7CI) Tartaric acid, di-p-toluate, (+)- (8CI) Rivastigmine Related Compound A (15 mg) ((+)-Di-p-toluoyl-D-(+)-tartaric acid) (2S,35)-(-)-di-o-4-Toluoyl-D-tartaric acid 2,3-bis[(4-methylbenzoyl)oxy]-,[s-(theta,theta)]-butanedioicaci 2,3-Bis[(4-methylbenzoyl)oxy]succinic acid 2,3-DI-O-PARA-TOLUOYL-D-TARTARICACIDHYDRATE Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, [S-(R*,R*)]- L-di-p-Toluyltartaric acid 2,3-Di-O-para-toluoyl-D-tartaric acid (2S,3S)-2,3-BIS-(4-METHYL-BENZOYLOXY)-SUCCINIC ACID (2S,3S)-(+)-DI-O-4-TOLUOYL-TARTARIC ACID D-(+)-DI-P-TOLUOYL TARTARIC ACID (+)-O,O'-Di-1,4-toluoyl-D-tartaric acid L-(-)-DI-P-TOLUOYL-D-TARTARIC ACID (+)-Bis-O,O'-(4-toluoyl)-D-tartrate (+)-Di-O,O'-p-toluoyltartaric acid (2S,3S)-(+)-Di-p-toluoyltartaric acid Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)- Di-O,OP-Toluyl-D-TartaricAcid(Anhydrous) (+)-2-O,3-O-Di-p-toluoyl-D-tartaric acid