Methyl 2-fluoro-6-hydroxybenzoate
- CAS No.
- 72373-81-0
- Chemical Name:
- Methyl 2-fluoro-6-hydroxybenzoate
- Synonyms
- RARECHEM AL BF 1190;METHYL 6-FLUOROSALICYLATE;Methyl 2-fluoro-6-hydroxybenzoate;METHYL 6-FLUORO-2-HYDROXYBENZOATE;2-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER;BENZOIC ACID,2-FLUORO-6-HYDROXY-, METHYL ESTER;METHYL 2-FLUORO-6-HYDROXYBENZOATE ISO 9001：2015 REACH;Methyl 6-fluorosalicylate, 3-Fluoro-2-(methoxycarbonyl)phenol
- CBNumber:
- CB8229548
- Molecular Formula:
- C8H7FO3
- Molecular Weight:
- 170.14
- MDL Number:
- MFCD00153207
- MOL File:
- 72373-81-0.mol
- MSDS File:
- SDS
| Melting point | 71°C |
|---|---|
| Boiling point | 65-70°C 1,7mm |
| Density | 1.309±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 8.76±0.10(Predicted) |
| form | liquid |
| color | Clear, colourless |
| CAS DataBase Reference | 72373-81-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HazardClass | IRRITANT |
| HS Code | 2916310090 |
Methyl 2-fluoro-6-hydroxybenzoate price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM33655 | Methyl 2-fluoro-6-hydroxybenzoate | 72373-81-0 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FM33655 | Methyl 2-fluoro-6-hydroxybenzoate | 72373-81-0 | 1g | $150 | 2026-06-04 | Buy |
| Biosynth | FM33655 | Methyl 2-fluoro-6-hydroxybenzoate | 72373-81-0 | 5g | $230.55 | 2026-06-04 | Buy |
| Biosynth | FM33655 | Methyl 2-fluoro-6-hydroxybenzoate | 72373-81-0 | 10g | $346 | 2026-06-04 | Buy |
| Apolloscientific | PC5092 | Methyl 2-fluoro-6-hydroxybenzoate 98% | 72373-81-0 | 1g | $21 | 2026-06-04 | Buy |
Methyl 2-fluoro-6-hydroxybenzoate Chemical Properties, Uses, Production
Synthesis
67-56-1
67531-86-6
72373-81-0
Procedure for the synthesis of methyl 2-fluoro-6-hydroxybenzoate (2): 2-fluoro-6-hydroxybenzoic acid (Oakwood Products; 0.972 kg, 6.31 mol), methanol (7.60 L), and sulfuric acid (0.710 kg, 7.24 mol, 1.15 eq.) were added to a 20 L jacketed reactor. The jacket temperature was raised to 60°C and the reaction mixture was stirred continuously for 45 hours. Upon completion of the reaction, about 7.5 L of methanol distillate was removed by vacuum concentration. The residue was cooled to 20 °C and extracted by adding water (7.60 L) and ethyl acetate (7.60 L) to transfer the product to the organic layer. The ethyl acetate layer was washed sequentially with aqueous sodium bicarbonate (1.52 Kg sodium bicarbonate dissolved in 6.92 L water) and aqueous sodium chloride (1.74 kg sodium chloride dissolved in 4.08 L water). The washed ethyl acetate solution was concentrated to dryness to give a light orange colored oily substance. After standing, the oily material gradually crystallized to give the target product methyl 2-fluoro-6-hydroxybenzoate (2) (0.952 Kg, 5.60 mol, 89% yield). The product was analyzed by 1H NMR, 13C NMR and mass spectrometry to confirm the structure.
References
[1] Organic Process Research and Development, 2016, vol. 20, # 2, p. 233 - 241
[2] Patent: WO2011/101774, 2011, A1. Location in patent: Page/Page column 25-26
[3] Acta Chemica Scandinavica, 1997, vol. 51, # 8, p. 881 - 888
Methyl 2-fluoro-6-hydroxybenzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Tianjin Ji Ping Jia Chemical Co., Ltd. | 18622448868 | jpjchem@163.com | China | 489 | 62 |
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