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2-tert-Butyl-1,3-diisopropylisourea

2-tert-Butyl-1,3-diisopropylisourea Structure
2-tert-Butyl-1,3-diisopropylisourea structure
CAS No.
71432-55-8
Chemical Name:
2-tert-Butyl-1,3-diisopropylisourea
Synonyms
tert-Butyl N,N'-diisopropylcarbamimidate;O-tert-Butyl-N,N'-diisopropylisourea;O-tert-Butyl-N,N'-diisopropylisourea;2-TERT-BUTYL-1;N,N'-diisopropyltert-butoxymethanimidamide;3-DIISOPROPYLISOUREA;2-tert-Butyl-1,3-diisopropylisourea;O-tert-Butyl-N,N'-diisopropylisourea >tert-Butyl N,N'-diisopropylimidocarbamate;tert-butyl N,N'-di(propan-2-yl)carbamimidate
CBNumber:
CB8239657
Molecular Formula:
C11H24N2O
Molecular Weight:
200.32
MDL Number:
MFCD06657672
MOL File:
71432-55-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:33
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2-tert-Butyl-1,3-diisopropylisourea Properties

Boiling point 61°C/10mmHg(lit.)
Density 0.89±0.1 g/cm3(Predicted)
refractive index 1.4240-1.4280
storage temp. Keep in dark place,Inert atmosphere,2-8°C
form clear liquid
pka 9.54±0.50(Predicted)
color Colorless to Almost colorless
InChI InChI=1S/C11H24N2O/c1-8(2)12-10(13-9(3)4)14-11(5,6)7/h8-9H,1-7H3,(H,12,13)
InChIKey FESDUDPSRMWIDL-UHFFFAOYSA-N
SMILES C(=NC(C)C)(OC(C)(C)C)NC(C)C

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2925290090

2-tert-Butyl-1,3-diisopropylisourea price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B4178 O-tert-Butyl-N,N'-diisopropylisourea >98.0%(T) 71432-55-8 1g $68 2026-04-30 Buy
TCI Chemical B4178 O-tert-Butyl-N,N'-diisopropylisourea >98.0%(T) 71432-55-8 5g $230 2026-04-30 Buy
Usbiological 419170 2-tert-Butyl-1,3-diisopropylisourea 71432-55-8 2.5g $468 2026-06-03 Buy
Usbiological 419170 2-tert-Butyl-1,3-diisopropylisourea 71432-55-8 25g $2654 2026-06-03 Buy
Usbiological 266129 2-Tert-Butyl-1,3-Diisopropylisourea Asreported 71432-55-8 500mg $382 2026-06-03 Buy
Product number Packaging Price Buy
B4178 1g $68 Buy
B4178 5g $230 Buy
419170 2.5g $468 Buy
419170 25g $2654 Buy
266129 500mg $382 Buy

2-tert-Butyl-1,3-diisopropylisourea Chemical Properties,Uses,Production

Physical Form

liquid

Uses

2-tert-Butyl-1,3-diisopropylisourea is a useful synthetic intermediate in the synthesis of 5-Oxo Atorvastatin tert-Butyl Ester (O847160) which is a Boc-protected derivative of Atorvastatin. 2-tert-Butyl-1,3-diisopropylisourea is also used as a reagent in the total synthesis of Citrafungin A which is an antifungal natural product.

Synthesis

N,N'-Diisopropylcarbodiimide

693-13-0

tert-Butanol

75-65-0

2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA

71432-55-8

GENERAL STEPS: CuCl (63.4 mg, 0.64 mmol, 1 mol%) was added to a solution of N,N'-diisopropylcarbodiimide (10.0 mL, 63.9 mmol, 1.0 equiv) in tert-butanol (6.97 mL, 73.5 mmol, 1.15 equiv). The reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, purification was carried out by distillation under reduced pressure (80°C, 25 mmHg). 2-tert-butyl-1,3-diisopropylisourea was obtained as a colorless oil (10.4 g, 51.9 mmol, 81% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.80-3.58 (1H, m, CH), 3.31-2.97 (1H, m, CH), 1.44 (9H, s, tBu), 1.19-1.01 (12H, m, Me2×2).

References

[1] Organic Letters, 2005, vol. 7, # 13, p. 2615 - 2618
[2] Chemistry - A European Journal, 2007, vol. 13, # 30, p. 8543 - 8563
[3] Beilstein Journal of Organic Chemistry, 2011, vol. 7, p. 1486 - 1493
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 10, p. 4204 - 4219
[5] Patent: EP2952517, 2015, A1. Location in patent: Paragraph 0217

2-tert-Butyl-1,3-diisopropylisourea synthesis

777031-92-2
75-65-0
71432-55-8
Synthesis of 2-tert-Butyl-1,3-diisopropylisourea from 1,2-Ethenediamine, N1,N2-bis(1-methylethyl)- and tert-Butanol

2-tert-Butyl-1,3-diisopropylisourea Preparation Products And Raw materials

Raw materials

tert-Butanol N,N'-Diisopropylcarbodiimide

Preparation Products

N-1-Boc-amino-3-cyclopentene 2-tert-Butyl-1,3-diisopropylisourea

2-tert-Butyl-1,3-diisopropylisourea Suppliers

Global( 163)Suppliers
Supplier Tel Email Country ProdList Advantage
Yantai Boyun Biological Technology Co. Ltd 13793517650 13793517650 2767277144@qq.com China 2856 58
Suzhou Victorypharm Co.,Ltd. 512-68242903 13916956214 sales@victory-pharm.com China 1523 58
Yangzhou modier Electronic Materials Co., Ltd 13761402923 19975033992 market@modeltemol.com China 7830 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Shaoyuan Technology (Shanghai) Co., Ltd. 021-50795510 4000665055 marketing@accelachem.com China 9985 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
shanghai science Bio-Pharmceutical.co,ltd. 021-021-57872719 13761402923 245662540@qq.com China 299 60
Supplier Advantage
Yantai Boyun Biological Technology Co. Ltd 58
Suzhou Victorypharm Co.,Ltd. 58
Yangzhou modier Electronic Materials Co., Ltd 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Shaoyuan Technology (Shanghai) Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
shanghai science Bio-Pharmceutical.co,ltd. 60

View Lastest Price from 2-tert-Butyl-1,3-diisopropylisourea manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA pictures 2023-09-24 2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA
71432-55-8
 98% 500kg Suzhou Laing Biotechnology Co.,Ltd
2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA pictures 2019-12-26 2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA
71432-55-8
 $1.00 1KG 99% 1000KGS Career Henan Chemical Co

2-tert-Butyl-1,3-diisopropylisourea Spectrum

2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA(71432-55-8)1HNMR

71432-55-8(2-tert-Butyl-1,3-diisopropylisourea)Related Search:

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CarbaMiMidic acid, N,N'-bis(1-Methylethyl)-, 1,1-diMethylethyl ester tert-Butyl N,N'-diisopropylimidocarbamate tert-butyl N,N'-bis(1-methylethyl)imidocarbamate O-tert-Butyl-N,N'-diisopropylisourea > 3-DIISOPROPYLISOUREA N,N'-bis(propan-2-yl)(tert-butoxy)methanimidamide 1,1-Dimethylethyl N,N'-bis(1-methylethyl)carbamimidate 1-[(2-methylprop-2-yl)oxy]-N-(prop-2-yl)-1-(prop-2-ylamino)methanimine 2-Methyl-2-propanyl N,N'-diisopropylcarbamimidate 2-Methyl-2-propanyl N,N'-diisopropylcarbamimidate 2-TERT-BUTYL-1 N,N'-diisopropyltert-butoxymethanimidamide O-tert-Butyl-N,N'-diisopropylisourea O-tert-Butyl-N,N'-diisopropylisourea tert-Butyl N,N'-diisopropylcarbamimidate tert-butyl N,N'-di(propan-2-yl)carbamimidate 2-tert-Butyl-1,3-diisopropylisourea 71432-55-8 C11H24N2O