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ChemicalBook >> CAS DataBase List >>1-Bromo-4-(2,2,2-trifluoroethoxy)benzene

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene Structure
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene structure
CAS No.
106854-77-7
Chemical Name:
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene
Synonyms
UKRORGSYN-BB BBV-081072;4-(Trifluoroethoxy)bromobenzene;4-(2,2,2-Trifluoroethoxy)bromobenzene;1-Bromo-4-(2,2,2-trifluoroethoxy)benzene;4-bromo-1-(2,2,2-trifluoroethoxy)benzene;Benzene, 1-bromo-4-(2,2,2-trifluoroethoxy)-
CBNumber:
CB8242828
Molecular Formula:
C8H6BrF3O
Molecular Weight:
255.03
MDL Number:
MFCD07780193
MOL File:
106854-77-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:33
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1-Bromo-4-(2,2,2-trifluoroethoxy)benzene Properties

Boiling point 212.8±40.0 °C(Predicted)
Density 1.569±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
Appearance White to off-white Solid
InChI InChI=1S/C8H6BrF3O/c9-6-1-3-7(4-2-6)13-5-8(10,11)12/h1-4H,5H2
InChIKey SMDIDUHBHCDCRQ-UHFFFAOYSA-N
SMILES C1(Br)=CC=C(OCC(F)(F)F)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P260-P280-P271
HS Code  2909309090

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC99250 4-(Trifluoroethoxy)bromobenzene >97% 106854-77-7 1g $21 2026-06-04 Buy
Apolloscientific PC99250 4-(Trifluoroethoxy)bromobenzene >97% 106854-77-7 5g $39 2026-06-04 Buy
Apolloscientific PC99250 4-(Trifluoroethoxy)bromobenzene >97% 106854-77-7 25g $156 2026-06-04 Buy
Apolloscientific PC99250 4-(Trifluoroethoxy)bromobenzene >97% 106854-77-7 100g $615 2026-06-04 Buy
Apolloscientific PC500829 4-(2,2,2-Trifluoroethoxy)bromobenzene >97% 106854-77-7 1g $21 2026-06-04 Buy
Product number Packaging Price Buy
PC99250 1g $21 Buy
PC99250 5g $39 Buy
PC99250 25g $156 Buy
PC99250 100g $615 Buy
PC500829 1g $21 Buy

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene Chemical Properties, Uses, Production

Synthesis

4-Bromophenol

106-41-2

2,2,2-Trifluoroethyl trifluoromethanesulfonate

6226-25-1

1-BROMO-4-(2,2,2-TRIFLUOROETHOXY)BENZENE

106854-77-7

General procedure for the synthesis of 1-bromo-4-(2,2,2-trifluoroethoxy)benzene from 4-bromophenol and 2,2,2-trifluoroethyl trifluoromethanesulfonate: first, 4-bromophenol (9.57 g, 55 mmol) was dissolved in acetone (200 mL), followed by the addition of potassium carbonate (22.89 g, 166 mmol) and 2,2,2-trifluoroethyl trifluoromethanesulfonate ester (16.0 g, 69 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was filtered to remove the insoluble salt and then concentrated under reduced pressure at 300 mbar at 30 °C to remove the acetone. The final product was 1-bromo-4-(2,2,2-trifluoroethoxy)benzene as a waxy solid (more than 100% yield, as a small amount of acetone remained in the product).

References

[1] Patent: WO2005/822, 2005, A1. Location in patent: Page/Page column 44
[2] Patent: US2016/332999, 2016, A1. Location in patent: Paragraph 0576; 0577

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene Preparation Products And Raw materials

Raw materials

2,2,2-Trifluoroethanol 2,2,2-Trifluoroethyl methanesulfonate 4-Bromophenol 2,2,2-Trifluoroethyl p-toluenesulfonate 2-Bromophenol
Bis(4-bromophenyl)iodonium trifluoromethanesulfonate 2,2,2-Trifluoroethyl trifluoromethanesulfonate 4-Bromophenylboronic acid Acetone Potassium carbonate

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Preparation Products

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene Suppliers

Global Suppliers ( 74)
Supplier Tel Email Country ProdList Advantage
JINAN MEIGAO BIOPHARMATECH CO. LTD 13853286203 18205419756 shy96321@163.com China 20 58
Qingdao Port Liwei Import and Export Co., Ltd 13853286203 13853286203 shy96321@163.com China 40 58
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD 571-89189769 15168342188 China 228 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
AllyChem Co., Ltd. 0411-62313318 13889470786 info@allychem.com China 1021 65
Supplier Advantage
JINAN MEIGAO BIOPHARMATECH CO. LTD 58
Qingdao Port Liwei Import and Export Co., Ltd 58
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Nanjing Norris-Pharm Technology Co., Ltd 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
AllyChem Co., Ltd. 65

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene Spectrum

1-BROMO-4-(2,2,2-TRIFLUOROETHOXY)BENZENE(106854-77-7)1HNMR

106854-77-7 (1-Bromo-4-(2,2,2-trifluoroethoxy)benzene) Related Search:

2-(4-Bromo-phenoxy)-3,3,3-trifluoro-propylamine 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene 2,6-Bis(2,2,2-trifluoroethoxy)-3-bromobenzonitrile 5-bromo-2-(2,2,2-trifluoroethoxy)aniline RARECHEM AL BO 0707
2-Adamantyl-4-bromo-1-(2,2,2-trifluoroethoxy)benzene RARECHEM AL BW 0738

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UKRORGSYN-BB BBV-081072 4-(2,2,2-Trifluoroethoxy)bromobenzene Benzene, 1-bromo-4-(2,2,2-trifluoroethoxy)- 4-bromo-1-(2,2,2-trifluoroethoxy)benzene 4-(Trifluoroethoxy)bromobenzene 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene 106854-77-7 106854777