2,2,2-Trifluoroethyl p-toluenesulfonate
- CAS No.
- 433-06-7
- Chemical Name:
- 2,2,2-Trifluoroethyl p-toluenesulfonate
- Synonyms
- 2,2,2-TRIFLUOROETHYL 4-METHYLBENZENESULFONATE;2,2,2-trifluoroethyl ester;100532;TRIFLUORETHYLTOSYLATE;Trifluoroethyltosylate;Azithromycin Impurity 74;TRIFLUOROETHANOL TOSYLATE;2,2,2-TRIFLUOROETHYL P-TO;2,2,2-TRIFLUOROETHYL TOSYLATE;o-(p-tosyl)a,a,a,-trifluoroethanol
- CBNumber:
- CB2670852
- Molecular Formula:
- C9H9F3O3S
- Molecular Weight:
- 254.23
- MDL Number:
- MFCD00000443
- MOL File:
- 433-06-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 36-38 °C(lit.) |
|---|---|
| Boiling point | 87-92 °C0.1 mm Hg(lit.) |
| Density | 1 g/cm3 |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Sparingly), Methanol (Sparingly) |
| form | Solid |
| color | White to Off-White |
| Sensitive | Moisture Sensitive |
| BRN | 2699394 |
| Stability | Hygroscopic |
| InChI | 1S/C9H9F3O3S/c1-7-2-4-8(5-3-7)16(13,14)15-6-9(10,11)12/h2-5H,6H2,1H3 |
| InChIKey | IGKCQDUYZULGBM-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1)S(=O)(=O)OCC(F)(F)F |
| CAS DataBase Reference | 433-06-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanol, 2,2,2-trifluoro-, 4-methylbenzenesulfonate(433-06-7) |
| EPA Substance Registry System | Ethanol, 2,2,2-trifluoro-, 4-methylbenzenesulfonate (433-06-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,2,2-Trifluoroethyl p-toluenesulfonate price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 177822 | 2,2,2-Trifluoroethyl p-toluenesulfonate 99% | 433-06-7 | 50g | $119 | 2026-04-30 | Buy |
| TCI Chemical | T1516 | 2,2,2-Trifluoroethyl p-Toluenesulfonate >98.0%(GC)(T) | 433-06-7 | 25g | $101 | 2026-04-30 | Buy |
| TRC | TRC-T790230-50G | 2,2,2-Trifluoroethyl Tosylate | 433-06-7 | 50g | $91 | 2026-06-03 | Buy |
| TRC | TRC-T790230-250G | 2,2,2-Trifluoroethyl Tosylate | 433-06-7 | 250g | $302 | 2026-06-03 | Buy |
| TRC | TRC-T790230-100G | 2,2,2-Trifluoroethyl Tosylate | 433-06-7 | 100g | $154 | 2026-06-03 | Buy |
2,2,2-Trifluoroethyl p-toluenesulfonate Chemical Properties, Uses, Production
Chemical Properties
WHITE CRYSTALLINE SOLID
Uses
2,2,2-Trifluoroethyl Tosylate is a trifluoroethylation agent used in the preparation of 2,2,2-trifluoroethyl phenyl sulfone, a potential 2,2,2-trifluoroethyl pronucleophile.
Synthesis
2,2,2-Trifluoroethyl p-Toluenesulfonate is easily prepared by treating 2,2,2-trifluoroethanol with p-Toluenesulfonyl Chloride in pyridine or in aqueous acetone containing NaOH.
Precautions
Quite stable; can be handled without any special technique and stored at room temperature; use in a fume hood.
2,2,2-Trifluoroethyl p-toluenesulfonate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xinlian Rui Biomedical Technology (Shandong) Co., Ltd | 0531-84567878 15153173989 | 3865799121@qq.com | China | 79 | 58 |
| Jiaxing Fubo Biotechnology Co., Ltd. | 156-571-11153 18157018567; | sales@fluorio.com | China | 93 | 58 |
| SHANG FLUORO | 021-65170832 15601903708 | qinba_1@163.com | China | 401 | 60 |
| Shandong Zhishang Chemical Co. LTD | 15689709505 15508639737 | 2138533552@qq.com | China | 102 | 58 |
| Shandong Libixi Biopharmaceutical Technology Co., Ltd. | 15318973357; 15318973357 | 1460285141@qq.com | China | 9642 | 58 |
| Suzhou Lakestar Pharmatech Co., Ltd. | 0512-63970158-603 18018108880 | info@lakestarpharma.com | China | 401 | 59 |
| Shenyang Feikai Chemical Technology Co., Ltd. | 13840042777 13889276367 | 40825993@qq.com | China | 6 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
View Latest Price from 2,2,2-Trifluoroethyl p-toluenesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![]() |
2026-08-25 | 2,2,2-trifluoroethyl tosylate
433-06-7
|
$3.90-5.90 | 1KG | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | ||
![]() |
2026-08-07 | 222-TRIFLUOROETHYL P-TOLUENESULFONATE
433-06-7
|
$1.00-100.00 | 1KG | 99% | 300KG | Shaanxi Dideu Medichem Co. Ltd | |
![]() |
2026-05-28 | Trifluoroethyl p-toluene sulfonate
433-06-7
|
$9.00 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-

- 2,2,2-trifluoroethyl tosylate
433-06-7
- $3.90-5.90
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-

- 222-TRIFLUOROETHYL P-TOLUENESULFONATE
433-06-7
- $1.00-100.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-

- Trifluoroethyl p-toluene sulfonate
433-06-7
- $9.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD





