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N-(p-Toluenesulfonyl)-L-phenylalanine

N-(p-Toluenesulfonyl)-L-phenylalanine structure

CAS No.: 13505-32-3

Chemical Name:: N-(p-Toluenesulfonyl)-L-phenylalanine

Synonyms: TOSYL-L-PHENYLALANINE;TOS-PHE-OH;Tos-Phe;Tos-L-Phe;os-Phe-OH;Ts-Phe-OH;Tos-L-Phe-OH;TOS-PHENYLALANINE-OH;N-TOSYL-L-PHENYLALANINE;P-TOSYL-L-PHENYLALANINE

CBNumber:: CB8243128

Molecular Formula:: C16H17NO4S

Molecular Weight:: 319.38

MDL Number:: MFCD00037251

MOL File:: 13505-32-3.mol

MSDS File:: SDS

Last updated:2026-09-12 18:55:33

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N-(p-Toluenesulfonyl)-L-phenylalanine Properties

Melting point	165 °C
Boiling point	517.7±60.0 °C(Predicted)
Density	1.303±0.06 g/cm3(Predicted)
refractive index	-2.8 ° (C=4.5, Acetone)
storage temp.	Sealed in dry,Room Temperature
solubility	almost transparency in hot EtOH
form	powder to crystal
pka	3.31±0.10(Predicted)
color	White to Light yellow
InChI	InChI=1S/C16H17NO4S/c1-12-7-9-14(10-8-12)22(20,21)17-15(16(18)19)11-13-5-3-2-4-6-13/h2-10,15,17H,11H2,1H3,(H,18,19)/t15-/m0/s1
InChIKey	CGRCVIZBNRUWLY-HNNXBMFYSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=CC=C1)NS(C1=CC=C(C)C=C1)(=O)=O
CAS DataBase Reference	13505-32-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
Safety Statements	24/25
HazardClass	IRRITANT
HS Code	29224999

N-(p-Toluenesulfonyl)-L-phenylalanine price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T1443	N-(p-Toluenesulfonyl)-L-phenylalanine >98.0%(HPLC)(T)	13505-32-3	10g	$25	2022-04-27	Buy
TCI Chemical	T1443	N-(p-Toluenesulfonyl)-L-phenylalanine >98.0%(HPLC)(T)	13505-32-3	25g	$84	2026-04-30	Buy
TCI Chemical	T1443	N-(p-Toluenesulfonyl)-L-phenylalanine	13505-32-3	5G	$42	2026-04-30	Buy
Usbiological	291469	Tosyl-L-phenylalanine Asreported	13505-32-3	25g	$340	2026-06-03	Buy
Usbiological	291469	Tosyl-L-phenylalanine Asreported	13505-32-3	50g	$529	2026-06-03	Buy

Product number	Packaging	Price	Buy
T1443	10g	$25	Buy
T1443	25g	$84	Buy
T1443	5G	$42	Buy
291469	25g	$340	Buy
291469	50g	$529	Buy

N-(p-Toluenesulfonyl)-L-phenylalanine Chemical Properties, Uses, Production

Chemical Properties

White to off-white solid

Synthesis

63-91-2

98-59-9

13505-32-3

GENERAL STEPS: Sodium carbonate (Na2CO3, 1.590 g, 15 mmol) was added dropwise to an aqueous solution (15 mL) of L-phenylalanine (12.5 mmol) under continuous stirring conditions until complete dissolution. Subsequently, the reaction system was cooled to -5°C and p-toluenesulfonyl chloride (15 mmol) was slowly added in four portions over 1 hour. The reaction mixture was continued to be stirred at room temperature for 4 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was methanol/dichloromethane, 1:9). Upon completion of the reaction, the mixture was acidified with 20% aqueous hydrochloric acid to pH 2. The precipitated solid was collected by diafiltration and washed with pH 2.2 buffer. Finally, the purified product (S)-2-(4-methylphenylsulfonamido)-3-phenylpropionic acid was placed in a desiccator and dried using fused silica gel as desiccant.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 349 - 369
[2] PLoS ONE, 2018, vol. 13, # 1,
[3] RSC Advances, 2015, vol. 5, # 24, p. 18751 - 18760
[4] European Journal of Organic Chemistry, 2005, # 5, p. 934 - 938
[5] Journal of Organic Chemistry, 2012, vol. 77, # 9, p. 4375 - 4384

N-(p-Toluenesulfonyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials

L-Phenylalanine Tosyl chloride Sodium carbonate

Preparation Products

N-(p-Toluenesulfonyl)-L-phenylalanine Suppliers

Global Suppliers ( 180)

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Boya Seehot Pharmaceutical Co., Ltd.	0794-7053660	sales1@boyaseehot.com	China	17	58
Shanghai Chiral Chemicals Inc.	021-37285021 13472570865	tym7xi@aliyun.com	China	299	64
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Yangzhou Aoxin Chemical Co., Ltd	0514-87754778 13901446058	sales@aochem.com	China	69	66
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59

Supplier	Advantage
Jiangxi Boya Seehot Pharmaceutical Co., Ltd.	58
Shanghai Chiral Chemicals Inc.	64
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Yangzhou Aoxin Chemical Co., Ltd	66
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
Adamas Reagent, Ltd.	59
Shanghai Longsheng chemical Co.,Ltd.	59

View Latest Price from N-(p-Toluenesulfonyl)-L-phenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-27	N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3	$5.00-20.00	1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.
2019-07-06	N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3	$100.00	1KG	99%		Career Henan Chemical Co

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE
13505-32-3
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE
13505-32-3
$5.00-20.00
0.99
Hebei Yanxi Chemical Co., Ltd.

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE
13505-32-3
$100.00
99%
Career Henan Chemical Co

N-(p-Toluenesulfonyl)-L-phenylalanine Spectrum

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE(13505-32-3)¹HNMR

13505-32-3 (N-(p-Toluenesulfonyl)-L-phenylalanine) Related Search:

N-(p-Tolylsulphonyl)-L-glutamic acid N-p-Tosylglycine Tos-Lys(Boc)-OH Tos-Pro-OH (S)-(-)-N-[1-(Hydroxymethyl)-2-phenylethyl]-4-methylbenzenesulfonamide

Tos-Ala-OH Bsmoc-phenylalanine Bsmoc-tyrosine N-(p-Toluenesulfonyl)-L-phenylalanine 2-(Toluene-4-sulfonylamino)-propionic acid

TPCK Tosyl-L-Phenylalanine chloromethylketone N-Propyl-P-Toluenesulfonamide N-phenethylmethanesulphonamide N-(2-hydroxyethyl)benzenesulfonamide

SALOR-INT L173339-1EA

1of4

N-P-TOSYL-L-PHENYLALANINE 97% N-alpha-p-Toluolsulfonyl-L-phenylalanine Tos-L-Phe-OH TOS-PHENYLALANINE-OH P-TOSYL-L-PHENYLALANINE N-TOSYL-L-PHENYLALANINE N-P-TOSYL-L-PHENYLALANINE Tos-L-Phe N-tosyl-(S)-phenylalanine (2S)-2-(4-methylbenzenesulfonamido)-3-phenylpropanoic acid 2-{[(4-methylphenyl)sulfonyl]amino}-3-phenylpropanoic acid N-p-Toluenesulphonyl-L-phenylalanine N-[(4-Methylphenyl)sulfonyl]phenylalanine L-Phenylalanine, N-((4-methylphenyl)sulfonyl)- N-((4-Methylphenyl)sulfonyl)-L-phenylalanine Tos-Phe (S)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoic acid os-Phe-OH Tosyl-L-phenylalanine≥ 98% (HPLC) 2-[(4-methylphenyl)sulfonylamino]-3-phenyl-propionic acid N-(p-Toluenesulfonyl)-L-phenylalanine N-(P-TOLUENESULFONYL)-L-PHENYLALANINE USP/EP/BP (2S)-2-[(4-methylphenyl)sulfonylamino]-3-phenylpropanoic acid Factory supply N-(P-TOLUENESULFONYL)-L-PHENYLALANINE CAS 13505-32-3 high quality N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3 (S)-N-Tosylphenylalanine Ts-Phe-OH TOSYL-L-PHENYLALANINE TOS-PHE-OH N-(p-Toluenesulfonyl)-L-phenylalanine 13505-32-3 C6H5CH2CHNHSO2C6H4CH3CO2H CARBOXYLIC ACID Amino Acid Derivatives Amino Acids