3-CYANO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 914988-10-6
- Chemical Name:
- 3-CYANO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- TERT-BUTYL 3-CYANO-4-OXOPIPERIDINE-1-CARBOXYLATE;tert-butyl 4-cyano-3-oxopiperidine-1-carboxylate;Tert-butyl 3-cyano-4-oxo-1-piperidinecarboxylate;N-BOC-3-cyano-4-piperidone;N-BOC-3-cyano-4-oxopiperidine;1-BOC-3-cyano-4-oxopiperidine;1-Boc-4-oxopiperidine-3-carbonitrile;1,1-Dimethylethyl 3-cyano-4-oxo-1-piperidinecarboxylate;3-cyano-4-oxo-1-piperidinecarboxylic acid tert-butyl ester;3-CYANO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber:
- CB82455956
- Molecular Formula:
- C11H16N2O3
- Molecular Weight:
- 224.26
- MDL Number:
- MFCD11109814
- MOL File:
- 914988-10-6.mol
| Melting point | 97-99 °C |
|---|---|
| Boiling point | 375.1±42.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -3.72±0.40(Predicted) |
| color | Pale Yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H315-H319-H335-H226 |
| Precautionary statements | P501-P261-P240-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P304+P340+P312-P403+P233-P403+P235-P405 |
3-CYANO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C955865 | 3-Cyano-4-oxo-piperidine-1-carboxylicAcidtert-ButylEster | 914988-10-6 | 25mg | $45 | 2021-12-16 | Buy |
| TRC | C955865 | 3-Cyano-4-oxo-piperidine-1-carboxylicAcidtert-ButylEster | 914988-10-6 | 100mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC153957 | 3-Cyano-4-oxo-piperidine-1-carboxylic acid tert-butyl ester | 914988-10-6 | 250mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC153957 | 3-Cyano-4-oxo-piperidine-1-carboxylic acid tert-butyl ester | 914988-10-6 | 500mg | $100 | 2021-12-16 | Buy |
| Matrix Scientific | 072632 | 3-Cyano-4-oxo-piperidine-1-carboxylicacid tert-butyl ester 95+% | 914988-10-6 | 1g | $51 | 2021-12-16 | Buy |
3-CYANO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Uses
3-Cyano-4-oxo-piperidine-1-carboxylic Acid tert-Butyl Ester is a useful research reagent for organic synthesis and other chemical processes.
Synthesis
266353-22-4
914988-10-6
The general procedure for the synthesis of N-Boc-cyano-piperidin-4-one from ethyl 3-((tert-butoxycarbonyl)(2-cyanoethyl)amino)propionate was as follows: ethyl 3-((tert-butoxycarbonyl)(2-cyanoethyl)amino)propionate (17.3 g, 64.0 mmol) was dissolved in 200 mL of toluene and 60% sodium hydride (3.84 g, 96.0 mmol). The reaction mixture was heated to reflux and maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature, diluted with 200 mL of water, and the pH was subsequently adjusted to 3 with 1 N hydrochloric acid solution.The aqueous phase was extracted with ethyl acetate (200 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether as eluent to afford 7.8 g (51.6% yield) of tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate as a white solid.1H NMR (400 MHz, DMSO-d6) δ 10.87 (s, 1H), 3.89 (s, 2H), 3.46 (t, J=5.8Hz. 2H), 2.28 (t, J=5.8Hz, 2H).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 22, p. 9162 - 9183
[2] Patent: US2015/5277, 2015, A1. Location in patent: Paragraph 0208; 0209
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5195 - 5198
[4] Molecules, 2011, vol. 16, # 3, p. 2626 - 2635
[5] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 139; 140; 519; 520
3-CYANO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 9029 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from 3-CYANO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-13 | tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate
914988-10-6
|
US $5.90-3.90 / KG | 1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate
914988-10-6
- US $5.90-3.90 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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