2-Fluoro-3-hydroxybenzaldehyde
- CAS No.
- 103438-86-4
- Chemical Name:
- 2-Fluoro-3-hydroxybenzaldehyde
- Synonyms
- 2-Fluoro-3-hydroxybenzaldehyde;3-Hydroxy-2-fluorobenzaldehyde;Benzaldehyde, 2-fluoro-3-hydroxy-;2-Fluoro-3-hydroxybenzaldehyde 98%
- CBNumber:
- CB82456014
- Molecular Formula:
- C7H5FO2
- Molecular Weight:
- 140.11
- MDL Number:
- MFCD11110191
- MOL File:
- 103438-86-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2913000090 |
2-Fluoro-3-hydroxybenzaldehyde price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 276121 | 2-Fluoro-3-hydroxy benzaldehyde Asreported | 103438-86-4 | 250mg | $619 | 2026-06-03 | Buy |
| Usbiological | 276121 | 2-Fluoro-3-hydroxy benzaldehyde Asreported | 103438-86-4 | 500mg | $914 | 2026-06-03 | Buy |
| Usbiological | 276121 | 2-Fluoro-3-hydroxy benzaldehyde Asreported | 103438-86-4 | 1g | $1430 | 2026-06-03 | Buy |
| Usbiological | 276121 | 2-Fluoro-3-hydroxy benzaldehyde Asreported | 103438-86-4 | 2g | $1946 | 2026-06-03 | Buy |
| Usbiological | 276121 | 2-Fluoro-3-hydroxy benzaldehyde Asreported | 103438-86-4 | 5g | $2761 | 2026-06-03 | Buy |
2-Fluoro-3-hydroxybenzaldehyde Chemical Properties, Uses, Production
Synthesis Reference(s)
Synthesis, p. 710, 1988 DOI: 10.1055/s-1988-27681
Synthesis
103438-88-6
103438-86-4
General steps for the synthesis of 2-fluoro-3-hydroxybenzaldehyde from 2-fluoro-3-methoxybenzaldehyde: Step 1: Synthesis of 2-fluoro-3-hydroxybenzaldehyde. BBr3 (4 mL, 4 mmol, 1.0 M solution in heptane) was slowly added dropwise to a dichloromethane solution of 2-fluoro-3-methoxybenzaldehyde at -78 °C. The reaction mixture was stirred at -78 °C for 1 hour, followed by a slow warming to 0 °C and continued stirring for 2 hours. The reaction mixture was poured into water and extracted with ethyl acetate (3 x 10 mL). The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure and the residue was purified by silica gel column chromatography with the eluent being a 0-20% ethyl acetate-hexane solvent mixture to afford the target product 2-fluoro-3-hydroxybenzaldehyde (158 mg, 28% yield) as a white solid. MS data: MS m/z 141 [M + H]+.
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 10, p. 1982 - 1988
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4584 - 4597
[3] Patent: WO2005/82890, 2005, A1. Location in patent: Page/Page column 70
[4] Patent: WO2008/51494, 2008, A1. Location in patent: Page/Page column 115
[5] Patent: WO2013/61052, 2013, A1. Location in patent: Page/Page column 65
2-Fluoro-3-hydroxybenzaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Shanghai ShiXian Chemical Technology Co., Ltd. | 13764359345 | 990877971@qq.com | China | 1919 | 50 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
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