2-Fluoro-3-methoxybenzoic acid
- CAS No.
- 137654-20-7
- Chemical Name:
- 2-Fluoro-3-methoxybenzoic acid
- Synonyms
- 3-Carboxy-2-fluoroanisole;2-Fluoro-3-Methoxybenzoic acd;2-Fluoro-3-methoxybenzoic acid;2-Fluoro-3-methoxybenzoicacid98%;Benzoic acid, 2-fluoro-3-methoxy-;2-Fluoro-3-methoxybenzoic acid 98%;2-Fluoro-3-Methoxybenzoic Acid(WX612106)
- CBNumber:
- CB8780164
- Molecular Formula:
- C8H7FO3
- Molecular Weight:
- 170.14
- MDL Number:
- MFCD02179621
- MOL File:
- 137654-20-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 157-160°C |
|---|---|
| Boiling point | 296.6±20.0 °C(Predicted) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 3.15±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C8H7FO3/c1-12-6-4-2-3-5(7(6)9)8(10)11/h2-4H,1H3,(H,10,11) |
| InChIKey | AVGWCJLTQZQLCN-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC(OC)=C1F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2918999090 | |||||||||
| NFPA 704 |
|
2-Fluoro-3-methoxybenzoic acid price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1218 | 2-Fluoro-3-methoxybenzoic Acid >98.0%(GC)(T) | 137654-20-7 | 1g | $31 | 2026-04-30 | Buy |
| TCI Chemical | F1218 | 2-Fluoro-3-methoxybenzoic Acid >98.0%(GC)(T) | 137654-20-7 | 5g | $99 | 2026-04-30 | Buy |
| Apolloscientific | PC9295 | 2-Fluoro-3-methoxybenzoic acid 99% | 137654-20-7 | 5g | $32 | 2026-06-04 | Buy |
| Apolloscientific | PC9295 | 2-Fluoro-3-methoxybenzoic acid 99% | 137654-20-7 | 25g | $128 | 2026-06-04 | Buy |
| Apolloscientific | PC9295 | 2-Fluoro-3-methoxybenzoic acid 99% | 137654-20-7 | 100g | $414 | 2026-06-04 | Buy |
2-Fluoro-3-methoxybenzoic acid Chemical Properties, Uses, Production
Uses
2-Fluoro-3-methoxybenzoic acid (2FMBA) is an intramolecular lithium compound that has been shown to be a potent inhibitor of dihydrofolate reductase. Experiments have shown that 2FMBA can inhibit bacterial growth, bind to DNA, and inhibit RNA synthesis in bacteria.
Synthesis
321-28-8
137654-20-7
Step 1. Preparation of 2-fluoro-3-methoxybenzoic acid. Potassium tert-butoxide (30.80 g, 274 mmol) was dissolved in anhydrous tetrahydrofuran (300 mL) under nitrogen protection and the mixture was cooled to -78 °C. A hexane solution of 1.6 M n-butyllithium (172 mL, 275 mmol) was slowly added dropwise, and stirring was continued for 15 minutes after completion of the drop. Subsequently, 2-fluoroanisole (31.35 g, 248 mmol) was added and the reaction mixture continued to be stirred at -78 °C for 1.8 hours. Upon completion of the reaction, the mixture was slowly poured into a 2 L Erlenmeyer flask containing dry ice and gradually warmed to room temperature. Water (250 mL) was added to dilute and the organic layer was separated by extraction with ether (160 mL). The aqueous layer was acidified with concentrated hydrochloric acid to pH < 2. A solid was precipitated and collected by filtration to give 2-fluoro-3-methoxybenzoic acid (21.43 g, 51% yield) as a yellow solid. Melting point 155-160 °C. 1H NMR (acetone-d6, 300 MHz) δ 7.46 (ddd, J = 6.0, 1.8, 1.4 Hz, 1H), 7.36 (dt, J = 1.6, 8.1 Hz, 1H), 7.20 (dt, J = 1.4, 8.1 Hz, 1H), 3.92 (s, 3H); 19F NMR (acetone- d6, 300 MHz) δ -134.04 (m). Mass spectrum (ESI+): m/z 171 [M+H]+.
References
[1] Patent: US5547975, 1996, A
2-Fluoro-3-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
View Latest Price from 2-Fluoro-3-methoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-FLUORO-3-METHOXYBENZOIC ACID
137654-20-7
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-FLUORO-3-METHOXYBENZOIC ACID
137654-20-7
- $1.00
- 98%
- Career Henan Chemical Co
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