2-Fluorophenol
- CAS No.
- 367-12-4
- Chemical Name:
- 2-Fluorophenol
- Synonyms
- O-FLUOROPHENOL;1-Bromo-3-fluorobezene;uorophenoL;2-Florophenol;2-Flurophenol;o-fluoro-pheno;2-fluoro-pheno;2-FLUOROPHENOL;2-Fluorophenole;2-Fluorophenol f
- CBNumber:
- CB0495831
- Molecular Formula:
- C6H5FO
- Molecular Weight:
- 112.1
- MDL Number:
- MFCD00002155
- MOL File:
- 367-12-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 16.1 °C (lit.) |
|---|---|
| Boiling point | 171-172 °C/741 mmHg (lit.) |
| Density | 1.256 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 116 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 37.7g/l |
| form | Liquid |
| pka | 8.73(at 25℃) |
| Specific Gravity | 1.256 |
| color | Clear colorless to light yellow-brownish |
| Water Solubility | 80.72g/L(25 ºC) |
| BRN | 1905112 |
| Henry's Law Constant | 3.1×100 mol/(m3Pa) at 25℃, Abraham et al. (1994) |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C6H5FO/c7-5-3-1-2-4-6(5)8/h1-4,8H |
| InChIKey | HFHFGHLXUCOHLN-UHFFFAOYSA-N |
| SMILES | Oc1ccccc1F |
| CAS DataBase Reference | 367-12-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | I9OW1NLY9R |
| NIST Chemistry Reference | Phenol, 2-fluoro-(367-12-4) |
| EPA Substance Registry System | o-Fluorophenol (367-12-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P303+P361+P353-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,F,C,Xi,T | |||||||||
| Risk Statements | 20/21/22-36/37/38-10-63-43-23/24/25-45-40 | |||||||||
| Safety Statements | 28-36/37-36/37/39-26-16-24/25-23-53-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SL4530000 | |||||||||
| Hazard Note | Flammable/Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29081000 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Aquatic Chronic 3 Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Fluorophenol price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F12804 | 2-Fluorophenol 98% | 367-12-4 | 10g | $50.4 | 2026-04-30 | Buy |
| TCI Chemical | F0150 | 2-Fluorophenol >98.0%(GC) | 367-12-4 | 25g | $18 | 2026-04-30 | Buy |
| TCI Chemical | F0150 | 2-Fluorophenol >98.0%(GC) | 367-12-4 | 250g | $101 | 2026-04-30 | Buy |
| Strem Chemicals | 09-4070 | o-Fluorophenol, min. 98% min.98% | 367-12-4 | 10g | $52 | 2026-04-30 | Buy |
| Strem Chemicals | 09-4070 | o-Fluorophenol, min. 98% min.98% | 367-12-4 | 50g | $206 | 2026-04-30 | Buy |
2-Fluorophenol Chemical Properties, Uses, Production
Synthesis
1 mmol of phenol was added to 4 ml of 10% acetic acid aqueous solution, followed by the addition of 1.5 mmol of Selectfluor and 0.05 mmol of Eosin Y. The reaction was carried out under 12W blue light at room temperature for 6 hours. After the reaction was completed, saturated NaCl aqueous solution was added to the reaction solution, and the mixture was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, filtered, and evaporated under reduced pressure to obtain the crude compound. The crude compound was subjected to silica gel column chromatography using a mobile phase of ethyl acetate and petroleum ether in a volume ratio of 1:9. The eluent with an Rf value of 0.3-0.5 was collected by TLC. The collected eluent was subjected to solvent removal under reduced pressure and dried to obtain 90 mg of 2-fluorophenol (yield 77%).
Chemical Properties
Clear colourless to yellow liquid
Uses
2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria.
Synthesis Reference(s)
Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015
General Description
Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3.
Air & Water Reactions
Highly flammable.
Reactivity Profile
2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic and irritant.
Purification Methods
Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.]
2-Fluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huai'an Chenhui Technology Co., Ltd. | 13056011912 | jianshen1977@126.com | China | 26 | 58 |
| Weifang Weimeng Chemical Co., Ltd. | QQ 1340191485 15105445095 | weimengchem@163.com | China | 482 | 58 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Danyang Hengyu Chemical Co., Ltd | 13861235852 | 541510190@qq.com | China | 10 | 58 |
| Ningbo Zhenlei Chemical Co.,ltd. | 0576-88503603 15925898989 | wlh@zhenleichem.com | China | 126 | 58 |
| Jinan Gaochun Pharmaceutical Technology Co., Ltd. | 13287077755 13044030397 | 171790338@qq.com | China | 12 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 2-Fluorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 2-Fluorophenol
367-12-4
|
25KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | 2-Fluorophenol
367-12-4
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-08 | 2-Fluorophenol
367-12-4
|
99.0%min | 2000kg | Hangzhou ICH Biofarm Co., Ltd |
-
- 2-Fluorophenol
367-12-4
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Fluorophenol
367-12-4
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluorophenol
367-12-4
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
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