3-Aminophthalimide
- CAS No.
- 2518-24-3
- Chemical Name:
- 3-Aminophthalimide
- Synonyms
- 4-Aminoisoindoline-1,3-dione;3-AMINOPHTHALIMIDE;3-Amino-phthalamide;4-Amino-1H-isoindole;3-AMINOPHTHALIMIDE 99%;3-Aminophthalimide,99%;4-Amino-isoindole-1,3-dione;4-amino-1h-isoindole-3(2h)-dione;4-AMINO-1H-ISOINDOLE-1,3(2H)-DIONE;1H-Isoindole-1,3(2H)-dione,4-amino-
- CBNumber:
- CB8249564
- Molecular Formula:
- C8H6N2O2
- Molecular Weight:
- 162.15
- MDL Number:
- MFCD00041853
- MOL File:
- 2518-24-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Aminoisoindoline-1,3-dione min. 95.0 % | A3555 | 5G | $70 |
| 4-Aminoisoindoline-1,3-dione min. 95.0 % | A3555 | 25G | $246 |
| 3-Aminophthalimide 95% | J98578 | 1g | $43 |
| 3-Aminophthalimide 95% | J98578 | 5g | $124 |
| 3-Aminophthalimide 95% | J98578 | 10g | $206 |
| More product size | |||
| Melting point | 268.5-273.5 °C (lit.) |
|---|---|
| Boiling point | 288.82°C (rough estimate) |
| Density | 1.3264 (rough estimate) |
| refractive index | 1.5770 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 9.76±0.20(Predicted) |
| Appearance | Yellow to orange Solid |
| InChI | 1S/C8H6N2O2/c9-5-3-1-2-4-6(5)8(12)10-7(4)11/h1-3H,9H2,(H,10,11,12) |
| InChIKey | GQBONCZDJQXPLV-UHFFFAOYSA-N |
| SMILES | Nc1cccc2C(=O)NC(=O)c12 |
| CAS DataBase Reference | 2518-24-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Aminophthalimide(2518-24-3) |
| EPA Substance Registry System | 1H-Isoindole-1,3(2H)-dione, 4-amino- (2518-24-3) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 22-26-36/37-45 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29251995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Aminophthalimide price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A3555 | 4-Aminoisoindoline-1,3-dione min. 95.0 % | 2518-24-3 | 5G | $70 | 2026-04-30 | Buy |
| TCI Chemical | A3555 | 4-Aminoisoindoline-1,3-dione min. 95.0 % | 2518-24-3 | 25G | $246 | 2026-04-30 | Buy |
| AK Scientific | J98578 | 3-Aminophthalimide 95% | 2518-24-3 | 1g | $43 | 2026-06-04 | Buy |
| AK Scientific | J98578 | 3-Aminophthalimide 95% | 2518-24-3 | 5g | $124 | 2026-06-04 | Buy |
| AK Scientific | J98578 | 3-Aminophthalimide 95% | 2518-24-3 | 10g | $206 | 2026-06-04 | Buy |
3-Aminophthalimide Chemical Properties,Uses,Production
Chemical Properties
yellow fine powder
Uses
3-Aminophthalimide may be used in direct chemiluminescent cellular bioassays. It may also be used in the preparation of 3-bromopthalimide.
General Description
3-Aminophthalimide (API) is a stable precursor of luminol. API can be prepared by the hydrogenation of 3-nitrophthalimide and methanol in the presence of 10% Pd-C.
Synthesis
603-62-3
2518-24-3
The general procedure for the synthesis of 3-amino phthalimide from 3-nitrophthalimide was as follows: 3-nitrophthalimide (LOOGR) was placed in a hydrogenation reactor and dissolved by adding 500 mL of dimethylformamide (DMF). Subsequently, 20 g of wet Ruanne nickel catalyst was added to the solution. The hydrogenation reaction was started by applying a hydrogen pressure of 20-40 psi at 20-30 °C. After the initial exothermic phase of the reaction, the hydrogen pressure was increased to 40-60 psi and the reaction temperature was raised to 40-50 °C to continue the reaction. After the hydrogen is completely absorbed, a sample is taken and analyzed by thin layer chromatography (TLC) to confirm that the 3-nitrophthalimide has been completely converted. Upon completion of the reaction, the reaction mixture was filtered while hot to remove the catalyst. The filtrate was concentrated under reduced pressure at 60-80 °C to remove the solvent. To the residue was added 500 mL of water and stirred for 20-30 minutes. The product was separated by filtration and dried at 60-70 °C to give a yellow crystalline solid 3-aminophthalimide (80 g, 95% yield). The melting point of the product was 262-264 °C.
References
[1] MedChemComm, 2016, vol. 7, # 2, p. 292 - 296
[2] Patent: WO2004/43919, 2004, A1. Location in patent: Page 6
[3] Patent: WO2004/43919, 2004, A1. Location in patent: Page 7
[4] Journal of Chemical Research, 2011, vol. 35, # 6, p. 326 - 328
3-Aminophthalimide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 877 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1796 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 490 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
View Lastest Price from 3-Aminophthalimide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 3-Aminophthalimide
2518-24-3
|
$209.30 | 25Kg/Drum | 99.00%HPLC | 4tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2020-02-01 | 3-Aminophthalimide
2518-24-3
|
$1.00 | 1KG | 99% | 200kgs | Career Henan Chemical Co |
-
- 3-Aminophthalimide
2518-24-3
- $209.30
- 99.00%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 3-Aminophthalimide
2518-24-3
- $1.00
- 99%
- Career Henan Chemical Co
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