VCH-916
- CAS No.
- 1200133-34-1
- Chemical Name:
- VCH-916
- Synonyms
- CS-790;VCH-916;VCH-916, >=98%;VCH 916;VCH916;VCH-916 (Free);HCV,VCH 916,VCH916,Hepatitis C virus,VCH-916,inhibit,Inhibitor;potassiuM 5-cyclohexenyl-3-(N-((1r,4r)-4-Methoxycyclohexyl)-4-MethylcyclohexanecarboxaMido)thiophene-2-carboxylate;Potassium 5-(cyclohex-1-en-1-yl)-3-(trans-N-(trans-4-methoxycyclohexyl)-4-methylcyclohexane-1-carboxamido)thiophene-2-carboxylate;5-(1-Cyclohexen-1-yl)-3-[(trans-4-methoxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid potassium salt
- CBNumber:
- CB82504463
- Molecular Formula:
- C26H36KNO4S
- Molecular Weight:
- 497.73164
- MDL Number:
- MFCD25541650
- MOL File:
- 1200133-34-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
VCH-916 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1224 | VCH-916 98.38% | 1200133-34-1 | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-1224 | VCH-916 98.38% | 1200133-34-1 | 10mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-1224 | VCH-916 98.38% | 1200133-34-1 | 25mg | $406 | 2026-06-04 | Buy |
| ChemScene | CS-1224 | VCH-916 98.38% | 1200133-34-1 | 50mg | $650 | 2026-06-04 | Buy |
| ChemScene | CS-1224 | VCH-916 98.38% | 1200133-34-1 | 100mg | $1192 | 2026-06-04 | Buy |
VCH-916 Chemical Properties, Uses, Production
Uses
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor. IC50 Value: Target: HCV VCH-916 is a novel allosteric inhibitor of HCV NS5B polymerase. The RNA-dependent RNA polymerase (NS5B) of HCV is one of the attractive validated targets for development of new drugs to block HCV infection. VCH-916 is currently being evaluated for safety/tolerability, pharmacokinetics and anti-viral efficacy in chronically infected HCV patient.
References
[1] Ludmila Gerber, Tania M. Welzel, Stefan Zeuzem. New therapeutic strategies in HCV: polymerase inhibitors. Liver International. 2013,33(s1): 85-92
[2] Abdelrahman S. Mayhoub. Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure-activity and resistance relationships; different scaffolds and mutations. Bioorganic & Medicinal Chemistry. 2012, 20 (10): 3150-3161.
[3] Debasis Dasa, Jian Honga, Shu-Hui Chena, et al. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry. 2011, 19(16): 4690-4703
[4] Pierre L Beaulieu. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection. Informahealthcare. 2009, 19(2): 145-164
[5] Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection
VCH-916 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| ShangHai Onsyn-Chemical Technology Co., Ltd. | 13917628136 15900795984 | 572350448@qq.com | China | 259 | 55 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
| Lancrix Chemicals | 86-21-50817262 | sales@lancrix.com | China | 1498 | 55 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
