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ARRY-520

ARRY-520 Structure
ARRY-520 structure
CAS No.
885060-09-3
Chemical Name:
ARRY-520
Synonyms
Filanesib;ARRY 520 trifluoroacetate;CS-512;ARRY-520;Filanesib(ARRY-520);Arry-520 (Filanesib);ARRY-520 Hydrochloride;Filanesib, 10 mM in DMSO;FILANESIB;ARRY 520;ARRY520; (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
CBNumber:
CB82582928
Molecular Formula:
C20H22F2N4O2S
Molecular Weight:
420.48
MDL Number:
MFCD18633235
MOL File:
885060-09-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:24:03
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ARRY-520 Properties

Boiling point 511.3±60.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form solid
pka 10.10±0.10(Predicted)
color Off-white
FDA UNII 8A49OSO368

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

ARRY-520 price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21883 ARRY-520 ≥98% 885060-09-3 1mg $36 2026-04-30 Buy
Cayman Chemical 21883 ARRY-520 ≥98% 885060-09-3 5mg $120 2026-04-30 Buy
Cayman Chemical 21883 ARRY-520 ≥98% 885060-09-3 10mg $186 2026-04-30 Buy
Cayman Chemical 21883 ARRY-520 ≥98% 885060-09-3 25mg $420 2026-04-30 Buy
Usbiological 254672 ARRY 520 trifluoroacetate Asreported 885060-09-3 10mg $516 2026-06-03 Buy
Product number Packaging Price Buy
21883 1mg $36 Buy
21883 5mg $120 Buy
21883 10mg $186 Buy
21883 25mg $420 Buy
254672 10mg $516 Buy

ARRY-520 Chemical Properties, Uses, Production

Uses

(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide is a known potent kinesin spindle protein inhibitor

Biological Activity

arry 520 trifluoroacetate is a synthetic and salt form of ksp inhibitor with ic50 value of 6 nm.kinesin spindle protein (ksp) is one member of the mitotic kinesins involved in the early stages of mitosis responsible for centrosome separation.

in vitro

arry-520 had low nanomolar antiproliferative activity in various tumor cell lines and exhibited activity in multidrug-resistant cell lines. ec50s of arry-520 for proliferation inhibition in hct-15, nci/adr-res and k562/adr cells was 3.7, 14 and 4.2 nm, respectively, while paclitaxel ec50s in these cell lines was 35, 565 and 372 nm. moreover, k562/adr was found to be 118-fold resistant to paclitaxel when compared to the parent k562 line, but only 3.5-fold resistant to that of arry-520 [1].

in vivo

arry-520 was found to be active in uiso-bca-1 xenografts, which were completely resistant to paclitaxel. the antitumor efficacy of arry-520 was also found to be superior to paclitaxel in mice bearing ht-29, hct-116, mda-mb-231 and a2780 xenografts. arry-520 was superior to docetaxel in the androgen receptor-negative prostate cancer pc-3 xenograft model, and was also superior to docetaxel in the du145 prostate xenograft model [1].

IC 50

KSP: 6 nM (IC50)

ARRY-520 Preparation Products And Raw materials

Raw materials

Preparation Products

ARRY-520 Suppliers

Global Suppliers ( 96)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Shanghai Shanyuan pharmaceutical technology co., LTD 021-31761238 13167072949 3146446224@qq.com China 1420 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
MedChemexpress LLC 58
AdooQ BioScience, LLC 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
SPIRO PHARMA 55
Shanghai Shanyuan pharmaceutical technology co., LTD 55

View Latest Price from ARRY-520 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Filanesib(ARRY-520) pictures 2025-04-04 Filanesib(ARRY-520)
885060-09-3
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide pictures 2020-01-02 (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
885060-09-3
 $1.00 1KG Min98% HPLC Career Henan Chemical Co

ARRY-520 Spectrum

ARRY-520(885060-09-3)1HNMR

885060-09-3 (ARRY-520) Related Search:

CarbaMic acid, N-[3-[5-(2,5-difluorophenyl)-2,3-dihydro-3-[(MethoxyMethylaMino)carbonyl]-2-phenyl-1,3,4-thiadiazol-2-yl]propyl]-, 1,1-diMethylethyl ester (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride ARRY-520 ARRY-520 (R enantioMer) ARRY-520 (trifluoroacetate salt)
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(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2S)- Arry-520 (Filanesib) ARRY-520 FILANESIB;ARRY 520;ARRY520 ARRY-520 Hydrochloride Filanesib(ARRY-520) CS-512 (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate ARRY 520 trifluoroacetate (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide Filanesib, 10 mM in DMSO (s)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-n-methoxy-n-methyl-2-phenyl-1,3,4-thiadiazole-3(2h)-carboxamide Filanesib 885060-09-3 C20H22F2N4O2SCF3CO2H